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anti-DSCAM antibody :: Goat DSCAM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420303
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DSCAM, Polyclonal Antibody

 Also Known As   

Goat anti-DSCAM Antibody

 Product Synonym Names    DSCAM; Down syndrome cell adhesion molecule; CHD2-42; CHD2-52; human CHD2-52 down syndrome cell adhesion molecule; DSCAM antibody; Down syndrome cell adhesion molecule antibody; CHD2-42 antibody; CHD2-52 antibody; human CHD2-52 down syndrome cell adhesion molecule antibody
 Product Gene Name   

anti-DSCAM antibody

[Similar Products]
 Antibody/Peptide Pairs    DSCAM peptide (MBS426529) is used for blocking the activity of DSCAM antibody (MBS420303)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DSWDSAQRTK DVSPQ
 OMIM    602523
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DSWDSAQRTKDVSPQ, from the internal region of the protein sequence according to NP_001380.2; NP_996770.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_001380.2 and NP_996770.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-DSCAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DSCAM antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-DSCAM antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 170kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 174kDa according to NP_996770.1). Recommended concentration: 2-6ug/ml.
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 Western Blot (WB) of anti-DSCAM antibody    (2ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DSCAM antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DSCAM. It may not necessarily be applicable to this product.
 NCBI GI #    20127422
 NCBI GeneID    1826
 NCBI Accession #    NP_001380.2 [Other Products]
 NCBI Related Accession #    NP_996770.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001389.3 [Other Products]
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 UniProt Secondary Accession #    O60468 [Other Products]
 UniProt Related Accession #    O60469 [Other Products]
 Molecular Weight    173,804 Da
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 NCBI Official Full Name    Down syndrome cell adhesion molecule isoform CHD2-42
 NCBI Official Synonym Full Names    DS cell adhesion molecule
 NCBI Official Symbol    DSCAM [Similar Products]
 NCBI Official Synonym Symbols   
CHD2; CHD2-42; CHD2-52
[Similar Products]
 NCBI Protein Information    Down syndrome cell adhesion molecule
 UniProt Protein Name    Down syndrome cell adhesion molecule
 UniProt Synonym Protein Names   
CHD2
 Protein Family    Down syndrome cell adhesion molecule
 UniProt Gene Name    DSCAM [Similar Products]
 UniProt Entry Name    DSCAM_HUMAN
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 NCBI Summary for DSCAM    This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
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 UniProt Comments for DSCAM    DSCAM: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: axon; cell junction; extracellular region; growth cone; integral to plasma membrane; membrane; plasma membrane; synapse

Molecular Function: protein binding

Biological Process: cell adhesion; dendrite morphogenesis; homophilic cell adhesion; locomotory behavior; negative regulation of cell adhesion; nervous system development; positive regulation of axon extension involved in axon guidance; positive regulation of phosphorylation; post-embryonic retina morphogenesis in camera-type eye; synaptogenesis
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 Research Articles on DSCAM    1. The most significant was DSCAM, a neurological gene expressed widely in the developing brain and in the amygdala and hippocampus of the adult brain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DSCAM antibodyPathways associated with anti-DSCAM antibody
 Reference Product  PubMed Publications
 DCC antibody  >13 publications with DSCAM and DCC
 DSCAML1 antibody  >11 publications with DSCAM and DSCAML1
 PAK1 antibody  >6 publications with DSCAM and PAK1
 RAC1 antibody  >2 publications with DSCAM and RAC1
 MAPK8 antibody  >1 publications with DSCAM and MAPK8
 Products by Pathway  Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 DSCAM Interactions Pathway antibodies  DSCAM Interactions Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
Diseases associated with anti-DSCAM antibodyOrgans/Tissues associated with anti-DSCAM antibody
 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >20 publications with DSCAM and Abnormalities, Multiple
 Neurobehavioral Manifestations Antibodies  >19 publications with DSCAM and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >6 publications with DSCAM and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >4 publications with DSCAM and Heart Defects, Congenital
 Growth Disorders Antibodies  >3 publications with DSCAM and Growth Disorders
 Hypertrophy Antibodies  >2 publications with DSCAM and Hypertrophy
 Somatosensory Disorders Antibodies  >1 publications with DSCAM and Somatosensory Disorders
 Weight Loss Antibodies  >1 publications with DSCAM and Weight Loss
 Nerve Degeneration Antibodies  >1 publications with DSCAM and Nerve Degeneration
 Spinal Cord Diseases Antibodies  >1 publications with DSCAM and Spinal Cord Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with DSCAM and Brain
 Muscle Antibodies  >11 publications with DSCAM and Muscle
 Lung Antibodies  >3 publications with DSCAM and Lung
 Mammary Gland Antibodies  >1 publications with DSCAM and Mammary Gland
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