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anti-DUET antibody :: Rabbit DUET Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9602948
Western Blot (WB)
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DUET, Polyclonal Antibody

★Popular Item★
 Also Known As   

DUET Antibody

 Product Synonym Names    Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin (isoform 2); Kalirin; KALRN; KALRN_HUMAN; Protein Duo; RhoGEF kinase; Serine/threonine kinase with Dbl and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl-and pleckstrin homology domain; TRAD
 Product Gene Name   

anti-DUET antibody

[Similar Products]
 Product Synonym Gene Name    KALRN [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O60229
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    DUET antibody detects endogenous levels of total DUET
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human DUET
 Subcellular Location    Cytoskeleton
 Tissue Specificity    Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-DUET antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DUET antibody

   Function: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Subunit Structure: Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.
Post-translational Modifications: Autophosphorylated.
Similarity: The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
 Applications Tested/Suitable for anti-DUET antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-DUET antibody    WB: 1:1000-3000
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 Western Blot (WB) of anti-DUET antibody    Western blot analysis of DUET using HUVEC whole cell lysates
anti-DUET antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DUET. It may not necessarily be applicable to this product.
 NCBI GI #    148839466
 NCBI GeneID    8997
 NCBI Accession #    NP_001019831.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024660.4 [Other Products]
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 UniProt Primary Accession #    O60229 [Other Products]
 UniProt Secondary Accession #    Q6ZN45; Q8TBQ5; Q9NSZ4; Q9Y2A5; A8MSI4; C9JQ37 [Other Products]
 UniProt Related Accession #    O60229 [Other Products]
 Molecular Weight    Observed: 340 kDa
Predicted: 341 kDa
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 NCBI Official Full Name    kalirin isoform 1
 NCBI Official Synonym Full Names    kalirin RhoGEF kinase
 NCBI Official Symbol    KALRN [Similar Products]
 NCBI Official Synonym Symbols   
DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; ARHGEF24
[Similar Products]
 NCBI Protein Information    kalirin
 UniProt Protein Name    Kalirin
 UniProt Synonym Protein Names   
Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
 UniProt Gene Name    KALRN [Similar Products]
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 NCBI Summary for DUET    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
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 UniProt Comments for DUET    Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
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 Research Articles on DUET    1. The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively. Haplotype analysis revealed that A-T-G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke. Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DUET antibodyPathways associated with anti-DUET antibody
 Reference Product  PubMed Publications
 RAC1 antibody  >12 publications with DUET and RAC1
 MYLK antibody  >2 publications with DUET and MYLK
 ARF6 antibody  >2 publications with DUET and ARF6
 PAM antibody  >1 publications with DUET and PAM
 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 EPHB-mediated Forward Signaling Pathway antibodies  EPHB-mediated Forward Signaling Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with anti-DUET antibodyOrgans/Tissues associated with anti-DUET antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >11 publications with DUET and Brain Diseases
 Nervous System Diseases Antibodies  >11 publications with DUET and Nervous System Diseases
 Cognition Disorders Antibodies  >5 publications with DUET and Cognition Disorders
 Heart Diseases Antibodies  >5 publications with DUET and Heart Diseases
 Memory Disorders Antibodies  >4 publications with DUET and Memory Disorders
 Learning Disorders Antibodies  >4 publications with DUET and Learning Disorders
 Disease Models, Animal Antibodies  >3 publications with DUET and Disease Models, Animal
 Nerve Degeneration Antibodies  >1 publications with DUET and Nerve Degeneration
 Hyperplasia Antibodies  >1 publications with DUET and Hyperplasia
 Inflammation Antibodies  >1 publications with DUET and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with DUET and Brain
 Vascular Antibodies  >5 publications with DUET and Vascular
 Nerve Antibodies  >4 publications with DUET and Nerve
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