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anti-DUSP1 antibody :: Rabbit DUSP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126306
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DUSP1, Polyclonal Antibody

 Also Known As   

DUSP1 Polyclonal Antibody

 Product Synonym Names    HVH1; MKP1; CL100; MKP-1; PTPN10
 Product Gene Name   

anti-DUSP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600714
 3D Structure    ModBase 3D Structure for P28562
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A synthetic peptide of human DUSP1
 Calculated Molecular Weight    39kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-DUSP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-DUSP1 antibody

   The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
 Product Categories/Family for anti-DUSP1 antibody    Polyclonal
 Applications Tested/Suitable for anti-DUSP1 antibody   

Western Blot (WB)

 Application Notes for anti-DUSP1 antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-DUSP1 antibody    Western blot analysis of extracts of various cell lines, using DUSP1 antibody.
anti-DUSP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DUSP1. It may not necessarily be applicable to this product.
 NCBI GI #    1346900
 NCBI GeneID    1843
 NCBI Accession #    P28562.3 [Other Products]
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 UniProt Primary Accession #    P28562 [Other Products]
 UniProt Secondary Accession #    Q2V508; D3DQL9 [Other Products]
 UniProt Related Accession #    P28562 [Other Products]
 Molecular Weight    367
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 NCBI Official Full Name    Dual specificity protein phosphatase 1
 NCBI Official Synonym Full Names    dual specificity phosphatase 1
 NCBI Official Symbol    DUSP1 [Similar Products]
 NCBI Official Synonym Symbols   
HVH1; MKP1; CL100; MKP-1; PTPN10
[Similar Products]
 NCBI Protein Information    dual specificity protein phosphatase 1; MAP kinase phosphatase 1; protein-tyrosine phosphatase CL100; dual specificity protein phosphatase hVH1; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 1
 UniProt Protein Name    Dual specificity protein phosphatase 1
 UniProt Synonym Protein Names   
Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100
 Protein Family    Dual specificity protein phosphatase
 UniProt Gene Name    DUSP1 [Similar Products]
 UniProt Synonym Gene Names    CL100; MKP1; PTPN10; VH1; MAP kinase phosphatase 1; MKP-1 [Similar Products]
 UniProt Entry Name    DUS1_HUMAN
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 NCBI Summary for DUSP1    The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DUSP1    MKP-1: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation. It is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Contains 1 rhodanese domain.

Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.48; Motility/polarity/chemotaxis; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cytoplasm; nucleus

Molecular Function: protein tyrosine/threonine phosphatase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process: negative regulation of MAP kinase activity; response to light stimulus; response to retinoic acid; response to cAMP; negative regulation of MAPKKK cascade; positive regulation of apoptosis; response to glucocorticoid stimulus; negative regulation of meiotic cell cycle; response to testosterone stimulus; protein amino acid dephosphorylation; response to estradiol stimulus; cellular response to hormone stimulus; regulation of apoptosis; response to hydrogen peroxide; endoderm formation; response to oxidative stress; response to calcium ion; negative regulation of apoptosis; inactivation of MAPK activity
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 Research Articles on DUSP1    1. MKP-1 and MKP-2 stability is regulated by ERK-mediated phosphorylation through a degradation pathway independent of polyubiquitination
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DUSP1 antibodyPathways associated with anti-DUSP1 antibody
 Reference Product  PubMed Publications
 JUN antibody  >208 publications with DUSP1 and JUN
 MAPK1 antibody  >117 publications with DUSP1 and MAPK1
 MAPK3 antibody  >98 publications with DUSP1 and MAPK3
 FOS antibody  >58 publications with DUSP1 and FOS
 EGR1 antibody  >13 publications with DUSP1 and EGR1
 MAPK8 antibody  >6 publications with DUSP1 and MAPK8
 MAPK14 antibody  >5 publications with DUSP1 and MAPK14
 MAPK12 antibody  >1 publications with DUSP1 and MAPK12
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 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Regulation Of P38-alpha And P38-beta Pathway antibodies  Regulation Of P38-alpha And P38-beta Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
Diseases associated with anti-DUSP1 antibodyOrgans/Tissues associated with anti-DUSP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >112 publications with DUSP1 and Inflammation
 Necrosis Antibodies  >90 publications with DUSP1 and Necrosis
 Lung Diseases Antibodies  >40 publications with DUSP1 and Lung Diseases
 Cardiovascular Diseases Antibodies  >37 publications with DUSP1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >32 publications with DUSP1 and Nervous System Diseases
 Liver Diseases Antibodies  >29 publications with DUSP1 and Liver Diseases
 Breast Neoplasms Antibodies  >29 publications with DUSP1 and Breast Neoplasms
 Hypertension Antibodies  >26 publications with DUSP1 and Hypertension
 Neoplasms, Experimental Antibodies  >25 publications with DUSP1 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >19 publications with DUSP1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >101 publications with DUSP1 and Blood
 Muscle Antibodies  >83 publications with DUSP1 and Muscle
 Brain Antibodies  >74 publications with DUSP1 and Brain
 Vascular Antibodies  >74 publications with DUSP1 and Vascular
 Lung Antibodies  >61 publications with DUSP1 and Lung
 Bone Antibodies  >50 publications with DUSP1 and Bone
 Liver Antibodies  >49 publications with DUSP1 and Liver
 Heart Antibodies  >44 publications with DUSP1 and Heart
 Nerve Antibodies  >30 publications with DUSP1 and Nerve
 Kidney Antibodies  >29 publications with DUSP1 and Kidney
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