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anti-DUSP10 antibody :: Goat DUSP10/MKP5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420639
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DUSP10/MKP5, Polyclonal Antibody

 Also Known As   

Goat anti-DUSP10/MKP5 Antibody

 Product Synonym Names    DUSP10; MKP5; dual specificity phosphatase 10; MKP-5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase; DUSP10 antibody; MKP5 antibody; dual specificity phosphatase 10 antibody; MKP-5 antibody; dual specificity phosphatase MKP-5 antibody; serine/threonine specific protein phosphatase antibody; DUSP10 / MKP5
 Product Gene Name   

anti-DUSP10 antibody

[Similar Products]
 Product Synonym Gene Name    MKP5 [Similar Products]
 Antibody/Peptide Pairs    DUSP10 / MKP5 peptide (MBS425571) is used for blocking the activity of DUSP10/MKP5 antibody (MBS420639)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    CRILTPKLMG VETVV
 OMIM    608867
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence CRILTPKLMGVETVV, from the C Terminus of the protein sequence according to NP_009138.1; NP_653329.1; NP_653330.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise both reported Human isofoms. The variants NP_653329.1 and NP_653330.1 represent identical protein.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-DUSP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DUSP10 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-DUSP10 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 53kDa band seen in Human Liver lysate. Recommended for use at 0.5-2ug/ml.
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 Western Blot (WB) of anti-DUSP10 antibody    Staining (0.5ug/ml) of Human Liver lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-DUSP10 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DUSP10. It may not necessarily be applicable to this product.
 NCBI GI #    6005812
 NCBI GeneID    11221
 NCBI Accession #    NP_009138.1 [Other Products]
 NCBI Related Accession #    NP_653329.1; NP_653330.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007207.5 [Other Products]
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 UniProt Secondary Accession #    Q6GSI4; Q9H9Z5; D3DTB4 [Other Products]
 UniProt Related Accession #    Q9Y6W6 [Other Products]
 Molecular Weight    16,110 Da
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 NCBI Official Full Name    dual specificity protein phosphatase 10
 NCBI Official Synonym Full Names    dual specificity phosphatase 10
 NCBI Official Symbol    DUSP10 [Similar Products]
 NCBI Official Synonym Symbols   
MKP5; MKP-5
[Similar Products]
 NCBI Protein Information    dual specificity protein phosphatase 10
 UniProt Protein Name    Dual specificity protein phosphatase 10
 UniProt Synonym Protein Names   
Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5; MKP-5
 Protein Family    Dual specificity protein phosphatase
 UniProt Gene Name    DUSP10 [Similar Products]
 UniProt Synonym Gene Names    MKP5; MAP kinase phosphatase 5; MKP-5 [Similar Products]
 UniProt Entry Name    DUS10_HUMAN
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 NCBI Summary for DUSP10    Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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 UniProt Comments for DUSP10    MKP-5: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm; nucleus

Molecular Function: MAP kinase phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity

Biological Process: inactivation of MAPK activity; JNK cascade; negative regulation of JNK activity; negative regulation of oligodendrocyte differentiation; oligodendrocyte differentiation; protein amino acid dephosphorylation; regulation of adaptive immune response; response to lipopolysaccharide; response to stress
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 Research Articles on DUSP10    1. In females, three SNPs were associated with decreased colorectal cancer risk: rs11118838, rs12724393, and rs908858. However, in males, only one SNP, rs908858, was associated with decreased colorectal cancer risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DUSP10 antibodyPathways associated with anti-DUSP10 antibody
 Reference Product  PubMed Publications
 MAPK14 antibody  >2 publications with DUSP10 and MAPK14
 ATF2 antibody  >1 publications with DUSP10 and ATF2
 MAPK8 antibody  >1 publications with DUSP10 and MAPK8
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
 Downstream Signaling Of Activated FGFR2 Pathway antibodies  Downstream Signaling Of Activated FGFR2 Pathway Diagram
Diseases associated with anti-DUSP10 antibodyOrgans/Tissues associated with anti-DUSP10 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with DUSP10 and Inflammation
 Necrosis Antibodies  >8 publications with DUSP10 and Necrosis
 Prostatic Neoplasms Antibodies  >5 publications with DUSP10 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >4 publications with DUSP10 and Breast Neoplasms
 Disease Models, Animal Antibodies  >3 publications with DUSP10 and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with DUSP10 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with DUSP10 and Liver Neoplasms
 Edema Antibodies  >1 publications with DUSP10 and Edema
 Neoplasms, Experimental Antibodies  >1 publications with DUSP10 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with DUSP10 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >6 publications with DUSP10 and Muscle
 Liver Antibodies  >5 publications with DUSP10 and Liver
 Bone Antibodies  >3 publications with DUSP10 and Bone
 Vascular Antibodies  >3 publications with DUSP10 and Vascular
 Bone Marrow Antibodies  >2 publications with DUSP10 and Bone Marrow
 Intestine Antibodies  >2 publications with DUSP10 and Intestine
 Lung Antibodies  >2 publications with DUSP10 and Lung
 Kidney Antibodies  >2 publications with DUSP10 and Kidney
 Skin Antibodies  >1 publications with DUSP10 and Skin
 Testis Antibodies  >1 publications with DUSP10 and Testis
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