NP_085143.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,078 Da
NCBI Official Full Name
dual specificity protein phosphatase 16
NCBI Official Synonym Full Names
dual specificity phosphatase 16
NCBI Official Synonym Symbols
NCBI Protein Information
dual specificity protein phosphatase 16
UniProt Protein Name
Dual specificity protein phosphatase 16
UniProt Synonym Protein Names
Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7
UniProt Synonym Gene Names
UniProt Entry Name
DUS16_HUMAN
NCBI Summary for DUSP16
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
UniProt Comments for DUSP16
MKP-7: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain.
Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; nucleoplasm; nucleus
Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity
Biological Process: dephosphorylation; inactivation of MAPK activity; MAPK export from nucleus; MAPK phosphatase export from nucleus, leptomycin B sensitive
Research Articles on DUSP16
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-DUSP16 antibody
Pathways associated with anti-DUSP16 antibody
Diseases associated with anti-DUSP16 antibody
Organs/Tissues associated with anti-DUSP16 antibody
|