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anti-DUSP16 antibody :: Rabbit anti-Human DUSP16 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045838
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DUSP16, Polyclonal Antibody

★Popular Item★
 Also Known As   

DUSP16 Antibody

 Product Synonym Names    Dual specificity protein phosphatase 16; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7; DUSP16; KIAA1700; MKP7
 Product Gene Name   

anti-DUSP16 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607175
 3D Structure    ModBase 3D Structure for Q9BY84
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Dual specificity protein phosphatase 16 protein (C-250AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47903 / sc-47907 / sc-47904 / sc-98872
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DUSP16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DUSP16 antibody

   Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
 Applications Tested/Suitable for anti-DUSP16 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-DUSP16 antibody    Western blot
All lanes: DUSP16 antibody IgG at 1.69ug/ml+ 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 74,17 kDa
Observed band size: 73 kDa

anti-DUSP16 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-DUSP16 antibody    Immunohistochemistry of paraffin-embedded human lung tissue using MBS7045838 at dilution 1:100
anti-DUSP16 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DUSP16 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7045838 at dilution 1:100
anti-DUSP16 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DUSP16. It may not necessarily be applicable to this product.
 NCBI GI #    38372911
 NCBI GeneID    80824
 NCBI Accession #    NP_085143.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_030640.2 [Other Products]
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 UniProt Primary Accession #    Q9BY84 [Other Products]
 UniProt Secondary Accession #    Q547C7; Q96QS2; Q9C0G3 [Other Products]
 UniProt Related Accession #    Q9BY84 [Other Products]
 Molecular Weight    16,078 Da
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 NCBI Official Full Name    dual specificity protein phosphatase 16
 NCBI Official Synonym Full Names    dual specificity phosphatase 16
 NCBI Official Symbol    DUSP16 [Similar Products]
 NCBI Official Synonym Symbols   
MKP7; MKP-7
[Similar Products]
 NCBI Protein Information    dual specificity protein phosphatase 16
 UniProt Protein Name    Dual specificity protein phosphatase 16
 UniProt Synonym Protein Names   
Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7
 Protein Family    Dual specificity protein phosphatase
 UniProt Gene Name    DUSP16 [Similar Products]
 UniProt Synonym Gene Names    KIAA1700; MKP7; MAP kinase phosphatase 7; MKP-7 [Similar Products]
 UniProt Entry Name    DUS16_HUMAN
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 NCBI Summary for DUSP16    This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
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 UniProt Comments for DUSP16    MKP-7: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain.

Protein type: EC 3.1.3.48; EC 3.1.3.16; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: phosphoprotein phosphatase activity

Biological Process: dephosphorylation; inactivation of MAPK activity; MAPK export from nucleus; MAPK phosphatase export from nucleus, leptomycin B sensitive
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 Research Articles on DUSP16    1. The crystal structure of JNK1 bound to the catalytic domain of MKP7 at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DUSP16 antibodyPathways associated with anti-DUSP16 antibody
 Reference Product  PubMed Publications
 MAPK8 antibody  >2 publications with DUSP16 and MAPK8
 MAPK14 antibody  >2 publications with DUSP16 and MAPK14
 MAPK10 antibody  >1 publications with DUSP16 and MAPK10
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
 Downstream Signaling Of Activated FGFR2 Pathway antibodies  Downstream Signaling Of Activated FGFR2 Pathway Diagram
 Downstream Signaling Of Activated FGFR3 Pathway antibodies  Downstream Signaling Of Activated FGFR3 Pathway Diagram
Diseases associated with anti-DUSP16 antibodyOrgans/Tissues associated with anti-DUSP16 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with DUSP16 and Inflammation
 Immune System Diseases Antibodies  >4 publications with DUSP16 and Immune System Diseases
 Necrosis Antibodies  >4 publications with DUSP16 and Necrosis
 Disease Models, Animal Antibodies  >3 publications with DUSP16 and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with DUSP16 and Liver Diseases
 Insulin Resistance Antibodies  >2 publications with DUSP16 and Insulin Resistance
 Neoplasm Metastasis Antibodies  >1 publications with DUSP16 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >1 publications with DUSP16 and Lung Neoplasms
 Fatty Liver Antibodies  >1 publications with DUSP16 and Fatty Liver
 Liver Neoplasms Antibodies  >1 publications with DUSP16 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with DUSP16 and Blood
 Kidney Antibodies  >3 publications with DUSP16 and Kidney
 Liver Antibodies  >3 publications with DUSP16 and Liver
 Embryonic Tissue Antibodies  >2 publications with DUSP16 and Embryonic Tissue
 Muscle Antibodies  >2 publications with DUSP16 and Muscle
 Skin Antibodies  >2 publications with DUSP16 and Skin
 Lung Antibodies  >2 publications with DUSP16 and Lung
 Prostate Antibodies  >1 publications with DUSP16 and Prostate
 Lymph Antibodies  >1 publications with DUSP16 and Lymph
 Nerve Antibodies  >1 publications with DUSP16 and Nerve
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