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anti-DEFA1 antibody :: Rabbit anti-Human Defensin alpha 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205098
Western Blot (WB)
Unit / Price
0.1 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Defensin alpha 1 (DEFA1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Defensin alpha 1 Antibody

 Product Synonym Names    Neutrophil defensin 1, Defensin, alpha 1, HNP-1, HP-1, HP1, HP 1-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA1, DEF1,DEFA2, MRS
 Product Gene Name   

anti-DEFA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125220
 3D Structure    ModBase 3D Structure for P59665
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
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 Cellular Location    Secreted
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 Preparation and Storage    Store at -20C.
Stable for 12 months from date of receipt
 Other Notes    Small volumes of anti-DEFA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DEFA1 antibody

   Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
 Product Categories/Family for anti-DEFA1 antibody    Immunology; Neuroscience
 Applications Tested/Suitable for anti-DEFA1 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)-Paraffin

 Application Notes for anti-DEFA1 antibody    WB~~ 1:1000
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 Western Blot (WB) of anti-DEFA1 antibody    Anti-Defensin alpha 1 Antibody at 1:1000 dilution + huamn spleen lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution

Predicted band size : 10 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-DEFA1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DEFA1. It may not necessarily be applicable to this product.
 NCBI GI #    124248516
 NCBI GeneID    1667
 NCBI Accession #    NP_001035965.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042500.1 [Other Products]
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 UniProt Primary Accession #    P59665 [Other Products]
 UniProt Secondary Accession #    P11479; Q14125; Q6EZF6 [Other Products]
 UniProt Related Accession #    P59665 [Other Products]
 Molecular Weight    10 kDa
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 NCBI Official Full Name    neutrophil defensin 1 isoform 2 preproprotein
 NCBI Official Synonym Full Names    defensin, alpha 1B
 NCBI Official Symbol    DEFA1B [Similar Products]
 NCBI Official Synonym Symbols   
HP1; HP-1; HNP-1
[Similar Products]
 NCBI Protein Information    neutrophil defensin 1
 UniProt Protein Name    Neutrophil defensin 1
 UniProt Synonym Protein Names   
Defensin, alpha 1; HNP-1; HP-1; HP1
 Protein Family    Alpha-defensin
 UniProt Gene Name    DEFA1 [Similar Products]
 UniProt Synonym Gene Names    DEF1; DEFA2; MRS; HP-1; HP1; HP-2; HP2 [Similar Products]
 UniProt Entry Name    DEF1_HUMAN
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 NCBI Summary for DEFA1    Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
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 UniProt Comments for DEFA1    defensin, alpha 1: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular matrix; extracellular space; Golgi lumen; extracellular region

Biological Process: defense response to Gram-positive bacterium; estrogen receptor signaling pathway; innate immune response in mucosa; killing of cells of another organism; antibacterial humoral response; innate immune response; immune response; chemotaxis; defense response to fungus; defense response to virus
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Product References and Citations for anti-DEFA1 antibody

   Daher K.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7327-7331(1988).
Mars W.M.,et al.Blood 71:1713-1719(1988).
Wiedemann L.M.,et al.Leukemia 3:227-234(1989).
Mars W.M.,et al.J. Biol. Chem. 270:30371-30376(1995).
Linzmeier R.,et al.FEBS Lett. 321:267-273(1993).
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 Research Articles on DEFA1    1. binding of HNP1 to affected bacterial toxins caused their local unfolding, potentiated their thermal melting and precipitation, exposed new regions for proteolysis, and increased susceptibility to collisional quenchers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DEFA1 antibody
 Products by Pathway  Pathway Diagram
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