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anti-DSG1 antibody :: Goat Desmoglein 1/DSG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422216
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Desmoglein 1/DSG1, Polyclonal Antibody

 Also Known As   

Goat anti-Desmoglein 1/DSG1 Antibody

 Product Synonym Names    DSG1; desmoglein 1; CDHF4; DG1; DSG; desmosomal glycoprotein 1; pemphigus foliaceus antigen; DSG1 antibody; desmoglein 1 antibody; CDHF4 antibody; DG1 antibody; DSG antibody; desmosomal glycoprotein 1 antibody; pemphigus foliaceus antigen antibody; Desmoglein 1; Desmoglein 1 / DSG1
 Product Gene Name   

anti-DSG1 antibody

[Similar Products]
 Product Synonym Gene Name    DSG1 [Similar Products]
 Antibody/Peptide Pairs    Desmoglein 1 / DSG1 peptide (MBS425708) is used for blocking the activity of Desmoglein 1/DSG1 antibody (MBS422216)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    YTTSDTLKPS VHVHD
 OMIM    125670
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-YTTSDTLKPSVHVHD, from the internal region of the protein sequence according to NP_001933.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-DSG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DSG1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-DSG1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Skin showsstaining of the cellular membranes of keratinocytes. Recommended concentration, 4-6ug/ml.
Western Blot: Preliminary experiments in lysates of cell lines A431, HeLa, K562 and MOLT4 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
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 Immunohistochemistry (IHC) of anti-DSG1 antibody    (3.8ug/ml) staining of paraffin embedded Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-DSG1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DSG1. It may not necessarily be applicable to this product.
 NCBI GI #    119703744
 NCBI GeneID    1828
 NCBI Accession #    NP_001933.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001942.3 [Other Products]
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 UniProt Secondary Accession #    B7Z845 [Other Products]
 UniProt Related Accession #    Q02413 [Other Products]
 Molecular Weight    42,619 Da
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 NCBI Official Full Name    desmoglein-1 preproprotein
 NCBI Official Synonym Full Names    desmoglein 1
 NCBI Official Symbol    DSG1 [Similar Products]
 NCBI Official Synonym Symbols   
DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA
[Similar Products]
 NCBI Protein Information    desmoglein-1
 UniProt Protein Name    Desmoglein-1
 UniProt Synonym Protein Names   
Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
 Protein Family    Desmoglein
 UniProt Gene Name    DSG1 [Similar Products]
 UniProt Synonym Gene Names    CDHF4; DG1; DGI [Similar Products]
 UniProt Entry Name    DSG1_HUMAN
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 NCBI Summary for DSG1    This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
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 UniProt Comments for DSG1    DSG1: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1); also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: apical plasma membrane; cytosol; desmosome; integral to membrane; intercellular junction; internal side of plasma membrane; lateral plasma membrane; plasma membrane

Molecular Function: calcium ion binding; gamma-catenin binding; protein binding; toxin binding

Biological Process: calcium-dependent cell-cell adhesion; cell-cell adhesion; homophilic cell adhesion; intercellular junction assembly; maternal process involved in pregnancy; protein stabilization; response to progesterone stimulus

Disease: Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-ige; Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse
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 Research Articles on DSG1    1. Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression in human umbilical vein endothelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DSG1 antibodyPathways associated with anti-DSG1 antibody
 Reference Product  PubMed Publications
 DSP antibody  >23 publications with DSG1 and DSP
 KLK5 antibody  >8 publications with DSG1 and KLK5
 JUP antibody  >6 publications with DSG1 and JUP
 PKP1 antibody  >6 publications with DSG1 and PKP1
 KRT1 antibody  >4 publications with DSG1 and KRT1
 CASP3 antibody  >3 publications with DSG1 and CASP3
 PKP2 antibody  >2 publications with DSG1 and PKP2
 MET antibody  >1 publications with DSG1 and MET
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
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 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
Diseases associated with anti-DSG1 antibodyOrgans/Tissues associated with anti-DSG1 antibody
 Disease Name  Pubmed Publications
 Dermatitis Antibodies  >22 publications with DSG1 and Dermatitis
 Hypersensitivity Antibodies  >14 publications with DSG1 and Hypersensitivity
 Death Antibodies  >5 publications with DSG1 and Death
 Metabolic Diseases Antibodies  >5 publications with DSG1 and Metabolic Diseases
 Inflammation Antibodies  >4 publications with DSG1 and Inflammation
 Weight Loss Antibodies  >3 publications with DSG1 and Weight Loss
 Necrosis Antibodies  >3 publications with DSG1 and Necrosis
 Hyperplasia Antibodies  >3 publications with DSG1 and Hyperplasia
 Cardiovascular Diseases Antibodies  >2 publications with DSG1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with DSG1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >264 publications with DSG1 and Skin
 Mouth Antibodies  >25 publications with DSG1 and Mouth
 Connective Tissue Antibodies  >4 publications with DSG1 and Connective Tissue
 Heart Antibodies  >4 publications with DSG1 and Heart
 Brain Antibodies  >3 publications with DSG1 and Brain
 Stomach Antibodies  >2 publications with DSG1 and Stomach
 Muscle Antibodies  >2 publications with DSG1 and Muscle
 Testis Antibodies  >2 publications with DSG1 and Testis
 Intestine Antibodies  >1 publications with DSG1 and Intestine
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