Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow DSG2 rightarrow Polyclonal DSG2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • TWEAK Receptor Recombinant Protein
 • Interferon Alpha (IFN Alpha ) ELISA Kit
 • DMAP1 Antibody
 • Goat Ig anti Human IgA (Fc specific) immunofixation Secondary Antibody
 • ATM Antibody
 • DYNC1I1 Antibody
 • TRIM34 Antibody
 • A Disintegrin and Metalloprotease 28 (ADAM28) ELISA Kit
 • NPPA Antibody
 • Helicobacter pylori, Cag Antigen Antibody
 • FP ELISA Kit
 • CD163 Antibody
 • Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit
 • Extracellular calcium-sensing receptor (CASR) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-DSG2 antibody :: Rabbit Desmoglein 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175420
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Desmoglein 2 (DSG2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Anti-Desmoglein 2, DSG2

 Product Synonym Names    Desmoglein-2; desmoglein 2; ARVC 10 antibody; ARVC10 antibody; ARVD 10 antibody; ARVD10 antibody; Cadherin family member 5 antibody; CDHF 5 antibody; CDHF5 antibody; CMD1BB antibody; Desmoglein 2 antibody; Desmoglein-2 antibody; Desmoglein2 antibody; DSG 2 antibody; DSG2 antibody; DSG2_HUMAN antibody; HDGC antibody; HDGC included antibody; MGC117034 antibody; MGC117036 antibody; MGC117037 antibody
 Product Gene Name   

anti-DSG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    612877
 3D Structure    ModBase 3D Structure for Q14126
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Reacts with: Human, Rat
Predicted to work with: Mouse
Section Bar
 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Section Bar
 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human Desmoglein 2 (1104-1118aa STRVTKHSTVQHSYS), different from the related mouse and rat sequences by one amino acid.
 Reconstitution    0.2ml of distilled water will yield a concentration of 500ug/ml.
 Relevant detection    MBS provides a series of assays reacted with primary antibodies. Antibody can be be supported by chemiluminescence kit MBS176460 in WB, supported by MBS176451 in IHC (P)
Section Bar
 Preparation and Storage    At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time.

Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DSG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-DSG2 antibody

   Description: Rabbit IgG polyclonal antibody for Desmoglein-2(DSG2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.
 Applications Tested/Suitable for anti-DSG2 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-DSG2 antibody    WB:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu, Rat
Concluded Species: Ms

IHC-P:
Concentration: 0.5-1 ug/ml
Tested Species: Hu, Rat
Concluded Species: Ms
Antigen Retrieval: By Heat

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Section Bar
 Western Blot (WB) of anti-DSG2 antibody    Anti-Desmoglein 2 antibody, MBS175420, Western blotting
All lanes: Anti Desmoglein 2 (MBS175420) at 0.5ug/ml
Lane 1: HT1080 Whole Cell Lysate at 40ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: SW620 Whole Cell Lysate at 40ug
Lane 4: SCG Whole Cell Lysate at 40ug
Lane 5: COLO320 Whole Cell Lysate at 40ug
Predicted bind size: 122KD
Observed bind size: 122KD
anti-DSG2 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for DSG2. It may not necessarily be applicable to this product.
 NCBI GI #    148876773
 NCBI GeneID    1829
 NCBI Accession #    Q14126.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q14126 [Other Products]
 UniProt Secondary Accession #    Q4KKU6 [Other Products]
 UniProt Related Accession #    Q14126 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    Desmoglein-2
 NCBI Official Synonym Full Names    desmoglein 2
 NCBI Official Symbol    DSG2 [Similar Products]
 NCBI Official Synonym Symbols   
HDGC; CDHF5; ARVC10; ARVD10; CMD1BB
[Similar Products]
 NCBI Protein Information    desmoglein-2; HDGC; cadherin family member 5
 UniProt Protein Name    Desmoglein-2
 UniProt Synonym Protein Names   
Cadherin family member 5; HDGC
 Protein Family    Desmoglein
 UniProt Gene Name    DSG2 [Similar Products]
 UniProt Synonym Gene Names    CDHF5 [Similar Products]
 UniProt Entry Name    DSG2_HUMAN
Section Bar
 NCBI Summary for DSG2    Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for DSG2    DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Protein type: Membrane protein, integral; Cell adhesion; Calcium-binding

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: desmosome; cell surface; apical plasma membrane; integral to membrane; plasma membrane; intercellular junction; lateral plasma membrane

Molecular Function: calcium ion binding

Biological Process: maternal process involved in pregnancy; apoptosis; homophilic cell adhesion; response to progesterone stimulus; cell adhesion; cell structure disassembly during apoptosis

Disease: Cardiomyopathy, Dilated, 1bb; Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
Table BarTOPTable Bar
 Research Articles on DSG2    1. Desmoglein 2 expression attenuates migration of melanoma cells, mediated by downregulation of secretogranin II.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-DSG2 antibodyPathways associated with anti-DSG2 antibody
 Reference Product  PubMed Publications
 DSC2 antibody  >55 publications with DSG2 and DSC2
 DSP antibody  >45 publications with DSG2 and DSP
 PKP2 antibody  >42 publications with DSG2 and PKP2
 JUP antibody  >26 publications with DSG2 and JUP
 DSC1 antibody  >12 publications with DSG2 and DSC1
 TGFB3 antibody  >7 publications with DSG2 and TGFB3
 PKP3 antibody  >1 publications with DSG2 and PKP3
 CASP3 antibody  >1 publications with DSG2 and CASP3
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Diseases associated with anti-DSG2 antibodyOrgans/Tissues associated with anti-DSG2 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >50 publications with DSG2 and Heart Diseases
 Heart Defects, Congenital Antibodies  >41 publications with DSG2 and Heart Defects, Congenital
 Disease Models, Animal Antibodies  >7 publications with DSG2 and Disease Models, Animal
 Necrosis Antibodies  >6 publications with DSG2 and Necrosis
 Neoplasms, Experimental Antibodies  >5 publications with DSG2 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >5 publications with DSG2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >5 publications with DSG2 and Breast Neoplasms
 Inflammation Antibodies  >4 publications with DSG2 and Inflammation
 Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 Antibodies  >4 publications with DSG2 and Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
 Fibrosis Antibodies  >3 publications with DSG2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >35 publications with DSG2 and Heart
 Skin Antibodies  >28 publications with DSG2 and Skin
 Muscle Antibodies  >19 publications with DSG2 and Muscle
 Intestine Antibodies  >9 publications with DSG2 and Intestine
 Mouth Antibodies  >5 publications with DSG2 and Mouth
 Lung Antibodies  >4 publications with DSG2 and Lung
 Liver Antibodies  >4 publications with DSG2 and Liver
 Embryonic Tissue Antibodies  >4 publications with DSG2 and Embryonic Tissue
 Bladder Antibodies  >3 publications with DSG2 and Bladder
 Testis Antibodies  >3 publications with DSG2 and Testis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions