NP_803187
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,726 Da
NCBI Official Full Name
endoribonuclease Dicer isoform 1
NCBI Official Synonym Full Names
dicer 1, ribonuclease III
NCBI Official Synonym Symbols
DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE [Similar Products]
NCBI Protein Information
endoribonuclease Dicer
UniProt Protein Name
Endoribonuclease Dicer
UniProt Synonym Protein Names
Helicase with RNase motif; Helicase MOI
UniProt Synonym Gene Names
NCBI Summary for Dicer1
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
UniProt Comments for Dicer1
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Product References and Citations for anti-Dicer1 antibody
(1) Tabara, H., Yigit, E., Siomi, H., et al.The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.Cell 109 (7), 861-871 (2002).
Research Articles on Dicer1
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Products associated with anti-Dicer1 antibody
Pathways associated with anti-Dicer1 antibody
Diseases associated with anti-Dicer1 antibody
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