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anti-DKK4 antibody :: Rabbit anti-Human Dickkopf-related protein 4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1494927
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dickkopf-related protein 4 (DKK4), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Dickkopf-related protein 4 polyclonal Antibody(DKK4)

 Product Synonym Names    Dickkopf-4; Dkk-4; hDkk-4; DKK4
 Product Gene Name   

anti-DKK4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605417
 3D Structure    ModBase 3D Structure for Q9UBT3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Dickkopf-related protein 4 protein (19-224aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-14962 / sc-14961 / sc-25519
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DKK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DKK4 antibody

   Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
 Applications Tested/Suitable for anti-DKK4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-DKK4 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-DKK4 antibody    All lanes: Dickkopf-related protein 4 antibody at 8ug/ml
Lane 1:jurkat whole cell lysate
Lane 2:K562 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 25kDa
Observed band size: 25kDa

anti-DKK4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-DKK4 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS1494927 at dilution 1:100
anti-DKK4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-DKK4 antibody    Immunohistochemistry of paraffin-embedded human liver using MBS1494927 at dilution 1:100
anti-DKK4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for DKK4. It may not necessarily be applicable to this product.
 NCBI GI #    7657025
 NCBI GeneID    27121
 NCBI Accession #    NP_055235.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014420.2 [Other Products]
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 UniProt Primary Accession #    Q9UBT3 [Other Products]
 UniProt Secondary Accession #    Q3KNX0; Q9Y4C3 [Other Products]
 UniProt Related Accession #    Q9UBT3 [Other Products]
 Molecular Weight    24,876 Da
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 NCBI Official Full Name    dickkopf-related protein 4
 NCBI Official Synonym Full Names    dickkopf WNT signaling pathway inhibitor 4
 NCBI Official Symbol    DKK4 [Similar Products]
 NCBI Official Synonym Symbols   
DKK-4
[Similar Products]
 NCBI Protein Information    dickkopf-related protein 4
 UniProt Protein Name    Dickkopf-related protein 4
 Protein Family    Dickkopf-related protein
 UniProt Gene Name    DKK4 [Similar Products]
 UniProt Synonym Gene Names    Dickkopf-4; Dkk-4; hDkk-4 [Similar Products]
 UniProt Entry Name    DKK4_HUMAN
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 NCBI Summary for DKK4    This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DKK4    DKK4: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Belongs to the dickkopf family.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p11.2-p11.1

Cellular Component: extracellular region

Biological Process: multicellular organismal development; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway
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 Research Articles on DKK4    1. The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DKK4 antibodyPathways associated with anti-DKK4 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >33 publications with DKK4 and CTNNB1
 WIF1 antibody  >8 publications with DKK4 and WIF1
 WNT6 antibody  >3 publications with DKK4 and WNT6
 LRP6 antibody  >2 publications with DKK4 and LRP6
 LEF1 antibody  >2 publications with DKK4 and LEF1
 LRP5 antibody  >1 publications with DKK4 and LRP5
 WNT2B antibody  >1 publications with DKK4 and WNT2B
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway antibodies  Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
Diseases associated with anti-DKK4 antibodyOrgans/Tissues associated with anti-DKK4 antibody
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >6 publications with DKK4 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >4 publications with DKK4 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with DKK4 and Liver Diseases
 Genital Diseases, Female Antibodies  >4 publications with DKK4 and Genital Diseases, Female
 Inflammation Antibodies  >4 publications with DKK4 and Inflammation
 Kidney Diseases Antibodies  >4 publications with DKK4 and Kidney Diseases
 Breast Neoplasms Antibodies  >3 publications with DKK4 and Breast Neoplasms
 Fibrosis Antibodies  >2 publications with DKK4 and Fibrosis
 Neoplasms, Experimental Antibodies  >2 publications with DKK4 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with DKK4 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >8 publications with DKK4 and Embryonic Tissue
 Liver Antibodies  >7 publications with DKK4 and Liver
 Intestine Antibodies  >5 publications with DKK4 and Intestine
 Brain Antibodies  >4 publications with DKK4 and Brain
 Mammary Gland Antibodies  >3 publications with DKK4 and Mammary Gland
 Stomach Antibodies  >2 publications with DKK4 and Stomach
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