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anti-DISP1 antibody :: Goat Dispatched homolog 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420640
Immunofluorescence (IF)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dispatched homolog 1 (DISP1), Polyclonal Antibody

 Also Known As   

Goat anti-Dispatched homolog 1 Antibody

 Product Synonym Names    DISP1; DISPA; MGC13130; MGC16796; DKFZP434I0428; dispatched A; DISP1; dispatched homolog 1; dispatched homolog 1 (Drosophila); FLJ43740; MGC104180; DISPA antibody; MGC13130 antibody; MGC16796 antibody; DKFZP434I0428 antibody; dispatched A antibody; DISP1 antibody; dispatched homolog 1 antibody; dispatched homolog 1 (Drosophila) antibody; FLJ43740 antibody; MGC104180 antibody; Dispatched homolog 1; Dispatched homolog 1
 Product Gene Name   

anti-DISP1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Dispatched homolog 1 peptide (MBS425238) is used for blocking the activity of Dispatched homolog 1 antibody (MBS420640)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SELSGESLLI KTL
 OMIM    607502
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SELSGESLLIKTL, from the C Terminus of the protein sequence according to NP_116279.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-DISP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DISP1 antibody   

Peptide ELISA (EIA), Immunofluorescence (IF)

 Application Notes for anti-DISP1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave no signal but low background in Human Lung and A549 extracts at up to 1ug/ml.
Immunofluorescence: Cell membrane staining in cell line U87. These data corresponds to earlier findings in literature with different antibodies (Etheridge et al, Development.2010 Jan;137(1): 133-40; PMID: 20023168).
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 Immunofluorescence (IF) of anti-DISP1 antibody    (2.5ug/ml) staining of U87. Detected by immunofluorescence. Data provided by Dr. Aashir Awan, University of Madrid, Spain.
anti-DISP1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for DISP1. It may not necessarily be applicable to this product.
 NCBI GI #    25952134
 NCBI GeneID    84976
 NCBI Accession #    NP_116279.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032890.3 [Other Products]
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 UniProt Secondary Accession #    Q8N7C2; Q96I92; Q9H698; Q9H8H9; Q9UFA2 [Other Products]
 UniProt Related Accession #    Q96F81 [Other Products]
 Molecular Weight    170,934 Da
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 NCBI Official Full Name    protein dispatched homolog 1
 NCBI Official Synonym Full Names    dispatched RND transporter family member 1
 NCBI Official Symbol    DISP1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein dispatched homolog 1
 UniProt Protein Name    Protein dispatched homolog 1
 Protein Family    Protein dispatched
 UniProt Gene Name    DISP1 [Similar Products]
 UniProt Synonym Gene Names    DISPA [Similar Products]
 UniProt Entry Name    DISP1_HUMAN
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 NCBI Summary for DISP1    The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DISP1    DISP1: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Belongs to the dispatched family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: integral to membrane

Molecular Function: hedgehog receptor activity; peptide transporter activity; protein binding

Biological Process: determination of left/right symmetry; dorsal/ventral pattern formation; embryonic pattern specification; patched ligand processing; peptide transport; smoothened signaling pathway
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 Research Articles on DISP1    1. DISP-1 is required for non-small cell lung carcinoma cells proliferation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-DISP1 antibodyOrgans/Tissues associated with anti-DISP1 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >10 publications with DISP1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >9 publications with DISP1 and Abnormalities, Multiple
 Nervous System Diseases Antibodies  >7 publications with DISP1 and Nervous System Diseases
 Nervous System Malformations Antibodies  >6 publications with DISP1 and Nervous System Malformations
 Chromosome Aberrations Antibodies  >5 publications with DISP1 and Chromosome Aberrations
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >5 publications with DISP1 and Embryonic Tissue
 Brain Antibodies  >4 publications with DISP1 and Brain
 Bone Antibodies  >3 publications with DISP1 and Bone
 Eye Antibodies  >3 publications with DISP1 and Eye
 Connective Tissue Antibodies  >2 publications with DISP1 and Connective Tissue
 Lung Antibodies  >2 publications with DISP1 and Lung
 Blood Antibodies  >1 publications with DISP1 and Blood
 Prostate Antibodies  >1 publications with DISP1 and Prostate
 Bladder Antibodies  >1 publications with DISP1 and Bladder
 Testis Antibodies  >1 publications with DISP1 and Testis
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