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anti-RPN1 antibody :: Rabbit anti-Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000935
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (RPN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit polyclonal Antibody

 Product Synonym Names    OK/SW-cl.45; KIAA0115; OST48; DDOST; Oligosaccharyl transferase 48 kDa subunit; DDOST 48 kDa subunit
 Product Gene Name   

anti-RPN1 antibody

[Similar Products]
 Product Synonym Gene Name    RPN1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    180470
 3D Structure    ModBase 3D Structure for P04843
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12164 / sc-12163 / sc-25559
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RPN1 antibody

   This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome.
 Applications Tested/Suitable for anti-RPN1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-RPN1 antibody    Recommended dilution: WB:1:500-2000
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 Western Blot (WB) of anti-RPN1 antibody    Western blot
All lanes: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa
subunit antibody at 2ug/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 50kDa
Observed band size: 50kDa
Additional bands at: 20kDa,30kDa
.
anti-RPN1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RPN1 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7000935 at dilution of 1:100
anti-RPN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for RPN1. It may not necessarily be applicable to this product.
 NCBI GI #    4506675
 NCBI GeneID    6184
 NCBI Accession #    NP_002941.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002950.3 [Other Products]
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 UniProt Primary Accession #    P04843 [Other Products]
 UniProt Secondary Accession #    Q68DT1; B2R5Z0; D3DNB6 [Other Products]
 UniProt Related Accession #    P04843 [Other Products]
 Molecular Weight    68,569 Da [Similar Products]
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 NCBI Official Full Name    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
 NCBI Official Synonym Full Names    ribophorin I
 NCBI Official Symbol    RPN1 [Similar Products]
 NCBI Official Synonym Symbols   
OST1; RBPH1
[Similar Products]
 NCBI Protein Information    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
 UniProt Protein Name    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
 UniProt Synonym Protein Names   
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit; Ribophorin I; RPN-I; Ribophorin-1
 Protein Family    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase
 UniProt Gene Name    RPN1 [Similar Products]
 UniProt Synonym Gene Names    RPN-I [Similar Products]
 UniProt Entry Name    RPN1_HUMAN
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 NCBI Summary for RPN1    This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RPN1    RPN1: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Belongs to the OST1 family.

Protein type: Transferase; EC 2.4.99.18; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane; melanosome; membrane; oligosaccharyl transferase complex; rough endoplasmic reticulum

Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; protein binding

Biological Process: cellular protein metabolic process; gene expression; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein modification process; SRP-dependent cotranslational protein targeting to membrane; translation
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 Research Articles on RPN1    1. Data indicate that malectin functions by forming a complex with ribophorin I.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RPN1 antibodyPathways associated with anti-RPN1 antibody
 Reference Product  PubMed Publications
 RPN2 antibody  >16 publications with RPN1 and RPN2
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycosylation By Oligosaccharyltransferase Pathway antibodies  N-glycosylation By Oligosaccharyltransferase Pathway Diagram
 N-glycosylation By Oligosaccharyltransferase Pathway antibodies  N-glycosylation By Oligosaccharyltransferase Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Proteasome Degradation Pathway antibodies  Proteasome Degradation Pathway Diagram
Diseases associated with anti-RPN1 antibodyOrgans/Tissues associated with anti-RPN1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >3 publications with RPN1 and Anemia
 Congenital Abnormalities Antibodies  >3 publications with RPN1 and Congenital Abnormalities
 Necrosis Antibodies  >3 publications with RPN1 and Necrosis
 Lung Diseases Antibodies  >2 publications with RPN1 and Lung Diseases
 Heart Diseases Antibodies  >2 publications with RPN1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with RPN1 and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >1 publications with RPN1 and Nerve Degeneration
 Vascular Diseases Antibodies  >1 publications with RPN1 and Vascular Diseases
 Neurobehavioral Manifestations Antibodies  >1 publications with RPN1 and Neurobehavioral Manifestations
 Cell Transformation, Neoplastic Antibodies  >1 publications with RPN1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >9 publications with RPN1 and Bone
 Bone Marrow Antibodies  >9 publications with RPN1 and Bone Marrow
 Blood Antibodies  >6 publications with RPN1 and Blood
 Muscle Antibodies  >4 publications with RPN1 and Muscle
 Heart Antibodies  >4 publications with RPN1 and Heart
 Lung Antibodies  >3 publications with RPN1 and Lung
 Kidney Antibodies  >2 publications with RPN1 and Kidney
 Nerve Antibodies  >2 publications with RPN1 and Nerve
 Mouth Antibodies  >2 publications with RPN1 and Mouth
 Brain Antibodies  >2 publications with RPN1 and Brain
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