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anti-Drd1a antibody :: Rabbit anti-Human, Rat Dopamine Receptor D(1A) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622982 anti-Drd1a antibody
Unit / Price
0.1 mg  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dopamine Receptor D(1A) (Drd1a), Polyclonal Antibody

 Also Known As   

Dopamine Receptor D(1A) (DRD1A, D(1A) Dopamine Receptor, DADR, Dopamine D1 Receptor, Dopamine Receptor D1, DRD1)

 Product Synonym Names    Anti -Dopamine Receptor D(1A) (DRD1A, D(1A) Dopamine Receptor, DADR, Dopamine D1 Receptor, Dopamine Receptor D1, DRD1)
 Product Gene Name   

anti-Drd1a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_005116.2 (16655926..16658161). Location: 17p14
 3D Structure    ModBase 3D Structure for P18901
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Specificity    Recognizes human D(1A) dopamine receptor at 49kD. Species Crossreactivity
 Purity/Purification    Affinity Purified
Purified by affinity chromatography.
 Form/Format    Supplied as a lyophilized powder PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitute with 100ul sterile dH2O.
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 Immunogen    Synthetic peptide corresponding to aa425-437, DYDTDVSLEKIQP to human D(1A) dopamine receptor.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Drd1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Drd1a antibody

   D(1A) dopamine receptor (DRD1) is a multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family. DRD1 is one of five receptors for dopamine. DRD1 stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. At least 2 isoforms exist arising from alternate transcription initiation sites.
 Product Categories/Family for anti-Drd1a antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-Drd1a antibody   

Western Blot (WB)

 Application Notes for anti-Drd1a antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1ug/ml
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NCBI/Uniprot data below describe general gene information for Drd1a. It may not necessarily be applicable to this product.
 NCBI GI #    155369726
 NCBI GeneID    24316
 NCBI Accession #    NP_036678.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012546.2 [Other Products]
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 UniProt Primary Accession #    P18901 [Other Products]
 UniProt Secondary Accession #    P21669 [Other Products]
 UniProt Related Accession #    P18901 [Other Products]
 Molecular Weight    49,428 Da [Similar Products]
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 NCBI Official Full Name    D(1A) dopamine receptor
 NCBI Official Synonym Full Names    dopamine receptor D1A
 NCBI Official Symbol    Drd1a [Similar Products]
 NCBI Official Synonym Symbols   
D1a; Drd1; Drd-1
[Similar Products]
 NCBI Protein Information    D(1A) dopamine receptor; D(1A) dopamine receptor; Dopamine-1A receptor; dopamine D1 receptor; dopamine receptor 1A
 UniProt Protein Name    D(1A) dopamine receptor
 UniProt Synonym Protein Names   
Dopamine D1 receptor
 UniProt Gene Name    Drd1 [Similar Products]
 UniProt Synonym Gene Names    Drd1a [Similar Products]
 UniProt Entry Name    DRD1_RAT
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 NCBI Summary for Drd1a    induces dopamine sensitive adenylate cyclase activation; plays a role in regulating food intake [RGD]
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 UniProt Comments for Drd1a    DRD1: a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; cell; integral to plasma membrane; dendrite; dendritic spine; integral to membrane; caveola; cell soma; membrane; axon; plasma membrane; intracellular; nerve terminal; dendritic shaft; nucleus

Molecular Function: angiotensin receptor binding; G-protein coupled receptor activity; protein binding; dopamine receptor activity; protein heterodimerization activity; dopamine binding; protein complex binding; G-protein alpha-subunit binding; drug binding; dopamine D1 receptor-like receptor activity; D3 dopamine receptor binding; protein phosphatase binding; ATPase binding; receptor binding

Biological Process: response to nicotine; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); prepulse inhibition; thermoregulation; response to organic cyclic substance; G-protein signaling, adenylate cyclase activating pathway; adult walking behavior; protein import into nucleus; conditioned taste aversion; positive regulation of cAMP biosynthetic process; positive regulation of adenylate cyclase activity; phosphatidylinositol metabolic process; response to food; response to drug; phosphatidylinositol catabolic process; dopamine transport; dentate gyrus development; cerebral cortex GABAergic interneuron migration; adenylate cyclase activation; mating behavior; transmission of nerve impulse; social behavior; response to amino acid stimulus; response to organic nitrogen; G-protein signaling, coupled to cyclic nucleotide second messenger; response to ethanol; cellular response to insulin stimulus; response to steroid hormone stimulus; regulation of vasoconstriction; glucose import; operant conditioning; dopamine receptor signaling pathway; negative regulation of protein kinase activity; response to activity; positive regulation of membrane potential; regulation of ion transport; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; peristalsis; startle response; behavioral fear response; negative regulation of circadian sleep/wake cycle, sleep; generation of action potential; response to morphine; locomotory behavior; orbitofrontal cortex development; vasodilation; positive regulation of synaptic transmission, glutamatergic; response to estradiol stimulus; intracellular protein transport; synaptic transmission; synaptogenesis; muscle contraction; behavioral response to cocaine; visual learning; feeding behavior; negative regulation of cell migration; associative learning; dopamine receptor, adenylate cyclase activating pathway; grooming behavior; response to retinoic acid; striatum development; maternal behavior; regulation of dopamine metabolic process; response to amphetamine; hippocampus development; calcium-mediated signaling; learning; response to cocaine; astrocyte development; memory; G-protein coupled receptor protein signaling pathway; habituation; sensitization; positive regulation of release of sequestered calcium ion into cytosol; dopamine receptor, phospholipase C activating pathway; positive regulation of cell migration
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 Research Articles on Drd1a    1. D(1)-like-Gal(1) receptor heteromers act as processors that integrate signals of two different neurotransmitters, dopamine and galanin, to modulate hippocampal cholinergic neurotransmission.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Drd1a antibodyDiseases associated with anti-Drd1a antibody
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Hypothetical Network For Drug Addiction Pathway antibodies  Hypothetical Network For Drug Addiction Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >5 publications with Drd1a and Mental Disorders
 Brain Diseases Antibodies  >3 publications with Drd1a and Brain Diseases
 Cognition Disorders Antibodies  >2 publications with Drd1a and Cognition Disorders
 Huntington Disease Antibodies  >2 publications with Drd1a and Huntington Disease
 Neurodegenerative Diseases Antibodies  >2 publications with Drd1a and Neurodegenerative Diseases
 Substance-Related Disorders Antibodies  >2 publications with Drd1a and Substance-Related Disorders
 Dementia Antibodies  >2 publications with Drd1a and Dementia
 Epilepsy Antibodies  >1 publications with Drd1a and Epilepsy
 Seizures Antibodies  >1 publications with Drd1a and Seizures
 Memory Disorders Antibodies  >1 publications with Drd1a and Memory Disorders
Organs/Tissues associated with anti-Drd1a antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with Drd1a and Brain
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