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anti-DRD4 antibody :: Rabbit Dopamine Receptor D4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS613546 anti-DRD4 antibody
Unit / Price
0.05 mL  /  $700 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dopamine Receptor D4 (DRD4), Polyclonal Antibody

 Also Known As   

Dopamine Receptor D4 (DRD4)

 Product Synonym Names    Anti -Dopamine Receptor D4 (DRD4)
 Product Gene Name   

anti-DRD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (637305..640706). Location: 11p15.5
 OMIM    126452
 3D Structure    ModBase 3D Structure for P21917
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    Recognizes D4 Dopamine Receptor (Ac-176-185) and the reactivity of D4 Dopamine Receptor is 60%. Does not react to D1 Dopamine Receptor (9-21), D1 Dopamine Receptor, D2 Dopamine Receptor (272-282), D2 Dopamine Receptor, D3 Dopamine Receptor (2-10), D3 Dopamine Receptor, D5 Dopamine Receptor (23-35) and D5 Dopamine Receptor. Highly specific for this peptide sequence and are suitable for immunocytochemical detection of the D4 dopamine receptor.
 Purity/Purification    Purified
Purified
 Form/Format    Supplied as a lyophilized powder. Reconstitution with 0.1 ml of PBS which contains 10 mg/ml BSA
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 Immunogen    D4 (Ac-176-185) covalently attached onto a carrier protein
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-DRD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-DRD4 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-DRD4 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-DRD4 antibody    Suitable for use in ELISA, Western Blot and Immunocytochemistry.
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NCBI/Uniprot data below describe general gene information for DRD4. It may not necessarily be applicable to this product.
 NCBI GI #    291946
 NCBI GeneID    1815
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 UniProt Primary Accession #    P21917 [Other Products]
 UniProt Secondary Accession #    Q7Z7Q5; Q8NGM5; B0M0J7 [Other Products]
 UniProt Related Accession #    P21917; Q0MTB8; Q16303; Q76E76; Q8IZB1; Q8IZB2; Q8IZB3; Q8IZB4; Q8IZB5; Q8IZB6 [Other Products]
 Molecular Weight    48,361 Da [Similar Products]
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 NCBI Official Full Name    dopamine receptor D4
 NCBI Official Synonym Full Names    dopamine receptor D4
 NCBI Official Symbol    DRD4 [Similar Products]
 NCBI Official Synonym Symbols   
D4DR
[Similar Products]
 NCBI Protein Information    D(4) dopamine receptor; D(4) dopamine receptor; OTTHUMP00000164435; dopamine D4 receptor; D(2C) dopamine receptor; seven transmembrane helix receptor
 UniProt Protein Name    D(4) dopamine receptor
 UniProt Synonym Protein Names   
D(2C) dopamine receptor; Dopamine D4 receptor
 Protein Family    D(4) dopamine receptor
 UniProt Gene Name    DRD4 [Similar Products]
 UniProt Entry Name    DRD4_HUMAN
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 NCBI Summary for DRD4    This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq]
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 UniProt Comments for DRD4    DRD4: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; cell soma; integral to plasma membrane; dendritic spine; plasma membrane; terminal button; vesicle membrane; cell cortex

Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; protein binding; potassium channel regulator activity; dopamine receptor activity; dopamine binding; drug binding; SH3 domain binding

Biological Process: circadian rhythm; synaptic transmission, dopaminergic; fear response; behavioral fear response; positive regulation of dopamine uptake; adult locomotory behavior; activation of MAPK activity; short-term memory; regulation of neurotransmitter secretion; positive regulation of kinase activity; regulation of calcium-mediated signaling; behavioral response to ethanol; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; regulation of inhibitory postsynaptic membrane potential; negative regulation of cAMP biosynthetic process; behavioral response to cocaine; negative regulation of protein secretion; negative regulation of adenylate cyclase activity; response to amphetamine; regulation of dopamine metabolic process; social behavior; arachidonic acid secretion; regulation of circadian rhythm; cellular calcium ion homeostasis; olfactory learning; response to steroid hormone stimulus; retina development in camera-type eye; photoperiodism; dopamine receptor signaling pathway; positive regulation of sodium:hydrogen antiporter activity

Disease: Novelty Seeking Personality Trait; Attention Deficit-hyperactivity Disorder
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 Research Articles on DRD4    1. The effect of different pooling strategies and genetic models on the reported association between DRD4-exIII-Variable number of tandem repeats polymorphism and cigarette smoking, was investigated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DRD4 antibodyPathways associated with anti-DRD4 antibody
 Reference Product  PubMed Publications
 SRC antibody  >2 publications with DRD4 and SRC
 GRB2 antibody  >1 publications with DRD4 and GRB2
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Hypothetical Network For Drug Addiction Pathway antibodies  Hypothetical Network For Drug Addiction Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
Diseases associated with anti-DRD4 antibodyOrgans/Tissues associated with anti-DRD4 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >567 publications with DRD4 and Mental Disorders
 Attention Deficit Disorder with Hyperactivity Antibodies  >259 publications with DRD4 and Attention Deficit Disorder with Hyperactivity
 Attention Deficit and Disruptive Behavior Disorders Antibodies  >218 publications with DRD4 and Attention Deficit and Disruptive Behavior Disorders
 Schizophrenia Antibodies  >184 publications with DRD4 and Schizophrenia
 Substance-Related Disorders Antibodies  >108 publications with DRD4 and Substance-Related Disorders
 Bipolar Disorder Antibodies  >52 publications with DRD4 and Bipolar Disorder
 NOVELTY SEEKING PERSONALITY TRAIT Antibodies  >45 publications with DRD4 and NOVELTY SEEKING PERSONALITY TRAIT
 Anxiety Disorders Antibodies  >36 publications with DRD4 and Anxiety Disorders
 Psychotic Disorders Antibodies  >35 publications with DRD4 and Psychotic Disorders
 Neurodegenerative Diseases Antibodies  >31 publications with DRD4 and Neurodegenerative Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >284 publications with DRD4 and Brain
 Ovary Antibodies  >21 publications with DRD4 and Ovary
 Kidney Antibodies  >16 publications with DRD4 and Kidney
 Eye Antibodies  >15 publications with DRD4 and Eye
 Bone Antibodies  >1 publications with DRD4 and Bone
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