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anti-MRE11A antibody :: Rabbit anti-Human Double-strand break repair protein MRE11A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493565
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Double-strand break repair protein MRE11A, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Double-strand break repair protein MRE11A polyclonal Antibody(MRE11A)

 Product Synonym Names    Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A; MRE11A; HNGS1; MRE11
 Product Gene Name   

anti-MRE11A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600814
 3D Structure    ModBase 3D Structure for P49959
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Double-strand break repair protein MRE11A protein(1-205aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5859 / sc-5858 / sc-22767
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MRE11A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MRE11A antibody

   Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
 Applications Tested/Suitable for anti-MRE11A antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MRE11A antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-MRE11A antibody    All lanes: Double-strand break repair protein MRE11A antibody at 8ug/ml
Lane 1:293T whole cell lysate
Lane 2:K562 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 81,78,82 kDa
Observed band size: 81 kDa

anti-MRE11A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MRE11A antibody    Immunohistochemistry of paraffin-embedded human tonsil using MBS1493565 at dilution 1:100
anti-MRE11A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MRE11A antibody    Immunohistochemistry of paraffin-embedded human skin using MBS1493565 at dilution 1:100
anti-MRE11A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MRE11A. It may not necessarily be applicable to this product.
 NCBI GI #    24234690
 NCBI GeneID    4361
 NCBI Accession #    NP_005581.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005590.3 [Other Products]
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 UniProt Primary Accession #    P49959 [Other Products]
 UniProt Secondary Accession #    O43475; B3KTC7 [Other Products]
 UniProt Related Accession #    P49959 [Other Products]
 Molecular Weight    81,070 Da
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 NCBI Official Full Name    double-strand break repair protein MRE11A isoform 2
 NCBI Official Synonym Full Names    MRE11 homolog A, double strand break repair nuclease
 NCBI Official Symbol    MRE11A [Similar Products]
 NCBI Official Synonym Symbols   
ATLD; HNGS1; MRE11; MRE11B
[Similar Products]
 NCBI Protein Information    double-strand break repair protein MRE11A
 UniProt Protein Name    Double-strand break repair protein MRE11A
 UniProt Synonym Protein Names   
Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
 Protein Family    Double-strand break repair protein
 UniProt Gene Name    MRE11A [Similar Products]
 UniProt Synonym Gene Names    HNGS1; MRE11; MRE11 homolog 1; MRE11 homolog A [Similar Products]
 UniProt Entry Name    MRE11_HUMAN
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 NCBI Summary for MRE11A    This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MRE11A    MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: DNA-binding; Cell cycle regulation; Deoxyribonuclease; DNA repair, damage

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; cytosol; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body

Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity

Biological Process: cell proliferation; DNA duplex unwinding; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; double-strand break repair via synthesis-dependent strand annealing; heart development; innate immune response; intra-S DNA damage checkpoint; meiotic recombination; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; negative regulation of virion penetration into host cell; positive regulation of interferon type I production; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of mitotic recombination; response to DNA damage stimulus; sister chromatid cohesion; synapsis; telomere maintenance via telomerase; telomeric 3' overhang formation; viral reproduction

Disease: Ataxia-telangiectasia-like Disorder 1
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 Research Articles on MRE11A    1. Loss of the MRE11 protein predicts sensitivity to PARP-inhibitor sensitivity in vitro, defining it as an additional synthetic lethal gene with PARP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MRE11A antibodyPathways associated with anti-MRE11A antibody
 Reference Product  PubMed Publications
 RAD50 antibody  >321 publications with MRE11A and RAD50
 NBN antibody  >232 publications with MRE11A and NBN
 ATM antibody  >205 publications with MRE11A and ATM
 BRCA1 antibody  >65 publications with MRE11A and BRCA1
 RAD51 antibody  >56 publications with MRE11A and RAD51
 H2AFX antibody  >49 publications with MRE11A and H2AFX
 FANCD2 antibody  >11 publications with MRE11A and FANCD2
 XRCC6 antibody  >3 publications with MRE11A and XRCC6
 TERF2 antibody  >2 publications with MRE11A and TERF2
 TERF2IP antibody  >1 publications with MRE11A and TERF2IP
 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 DNA Double Strand Break Response Pathway antibodies  DNA Double Strand Break Response Pathway Diagram
Diseases associated with anti-MRE11A antibodyOrgans/Tissues associated with anti-MRE11A antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >48 publications with MRE11A and Chromosome Aberrations
 Breast Neoplasms Antibodies  >39 publications with MRE11A and Breast Neoplasms
 Chromosome Breakage Antibodies  >34 publications with MRE11A and Chromosome Breakage
 Anemia Antibodies  >16 publications with MRE11A and Anemia
 Ovarian Neoplasms Antibodies  >15 publications with MRE11A and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >14 publications with MRE11A and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >11 publications with MRE11A and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >10 publications with MRE11A and Carcinoma, Squamous Cell
 Colonic Neoplasms Antibodies  >10 publications with MRE11A and Colonic Neoplasms
 Disease Models, Animal Antibodies  >8 publications with MRE11A and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with MRE11A and Blood
 Lung Antibodies  >18 publications with MRE11A and Lung
 Brain Antibodies  >13 publications with MRE11A and Brain
 Prostate Antibodies  >10 publications with MRE11A and Prostate
 Kidney Antibodies  >10 publications with MRE11A and Kidney
 Liver Antibodies  >10 publications with MRE11A and Liver
 Bladder Antibodies  >9 publications with MRE11A and Bladder
 Testis Antibodies  >6 publications with MRE11A and Testis
 Skin Antibodies  >6 publications with MRE11A and Skin
 Bone Antibodies  >5 publications with MRE11A and Bone
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