NP_005581.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,070 Da
NCBI Official Full Name
double-strand break repair protein MRE11A isoform 2
NCBI Official Synonym Full Names
MRE11 homolog A, double strand break repair nuclease
NCBI Protein Information
double-strand break repair protein MRE11A
UniProt Protein Name
Double-strand break repair protein MRE11A
UniProt Synonym Protein Names
Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
UniProt Synonym Gene Names
UniProt Entry Name
MRE11_HUMAN
NCBI Summary for MRE11A
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for MRE11A
MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.
Protein type: DNA-binding; Cell cycle regulation; Deoxyribonuclease; DNA repair, damage
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; cytosol; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body
Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; manganese ion binding; nuclease activity; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity
Biological Process: cell proliferation; DNA duplex unwinding; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; double-strand break repair via synthesis-dependent strand annealing; heart development; innate immune response; intra-S DNA damage checkpoint; meiotic recombination; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; negative regulation of virion penetration into host cell; positive regulation of interferon type I production; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of mitotic recombination; response to DNA damage stimulus; sister chromatid cohesion; synapsis; telomere maintenance via telomerase; telomeric 3' overhang formation; viral reproduction
Disease: Ataxia-telangiectasia-like Disorder 1
Research Articles on MRE11A
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Products associated with anti-MRE11A antibody
Pathways associated with anti-MRE11A antibody
Diseases associated with anti-MRE11A antibody
Organs/Tissues associated with anti-MRE11A antibody
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