ACN81320.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
520,369 Da
NCBI Official Full Name
dynein, axonemal, heavy chain 11
NCBI Official Synonym Full Names
dynein axonemal heavy chain 11
NCBI Official Synonym Symbols
CILD7; DNHBL; DPL11; DNAHBL; DNAHC11 [Similar Products]
NCBI Protein Information
dynein heavy chain 11, axonemal
UniProt Protein Name
Dynein heavy chain 11, axonemal
UniProt Synonym Protein Names
Axonemal beta dynein heavy chain 11; Ciliary dynein heavy chain 11
NCBI Summary for DNAH11
This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
UniProt Comments for DNAH11
DNAH11: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Defects in DNAH11 are a cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Defects in DNAH11 are the cause of primary ciliary dyskinesia type 7 (CILD7). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein heavy chain family.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 7p15.3
Biological Process: determination of left/right symmetry; sperm motility
Disease: Ciliary Dyskinesia, Primary, 7
Research Articles on DNAH11
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Products associated with anti-DNAH11 antibody
Pathways associated with anti-DNAH11 antibody
Diseases associated with anti-DNAH11 antibody
Disease Name |
Pubmed Publications |
Heart Defects, Congenital Antibodies |
>15 publications with DNAH11 and Heart Defects, Congenital |
Cardiovascular Diseases Antibodies |
>15 publications with DNAH11 and Cardiovascular Diseases |
Infertility, Male Antibodies |
>6 publications with DNAH11 and Infertility, Male |
Fibrosis Antibodies |
>4 publications with DNAH11 and Fibrosis |
Ciliary Dyskinesia, Primary, 7 Antibodies |
>4 publications with DNAH11 and Ciliary Dyskinesia, Primary, 7 |
Genital Diseases, Male Antibodies |
>3 publications with DNAH11 and Genital Diseases, Male |
Disease Models, Animal Antibodies |
>2 publications with DNAH11 and Disease Models, Animal |
Infertility, Female Antibodies |
>1 publications with DNAH11 and Infertility, Female |
Inflammation Antibodies |
>1 publications with DNAH11 and Inflammation |
Coronary Disease Antibodies |
>1 publications with DNAH11 and Coronary Disease |
Organs/Tissues associated with anti-DNAH11 antibody
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