Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow FXYD5 rightarrow Polyclonal FXYD5  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Tyrosine 3-Tryptophan 5 Monooxygenase Activation Protein Zet... ELISA Kit
 • RAD51L1 Antibody
 • R-Spondin 1 (RSPO1) ELISA Kit
 • Transient Receptor Potential Cation Channel Subfamily V, Mem... ELISA Kit
 • 1,2-dihydroxy-3-keto-5-meth ylthiopentene dioxygenase (IscW_I... Recombinant Protein
 • Lysozyme (LZM) ELISA Kit
 • Cathelicidin Antimicrobial Peptide (CAMP) Antibody
 • Interleukin 10 (IL10) ELISA Kit
 • cellular retinoic acid binding protein 1 (CRABP1) Antibody
 • 29 kDa ribonucleoprotein, chloroplastic (RBP29) Recombinant Protein
 • Cerebellin-4 (CBLN4) ELISA Kit
 • tensin 1 (TNS1) ELISA Kit
 • Beta-catenin (CTNNB1) Antibody
 • Alstrom syndrome protein 1 (ALMS1) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-FXYD5 antibody :: Rabbit anti-Human Dysadherin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175496
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dysadherin (FXYD5), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Dysadherin antibody

 Product Synonym Names    FXYD domain-containing ion transport regulator 5; FXYD domain containing ion transport regulator 5; Dysad antibody; Dysadherin antibody; FXYD 5 antibody; FXYD domain containing ion transport regulator 5 antibody; FXYD domain-containing ion transport regulator 5 antibody; Fxyd5 antibody; FXYD5_HUMAN antibody; FXYD5RIC antibody; HSPC 113 antibody; HSPC113 antibody; IWU 1 antibody; IWU1 antibody; KCT 1 antibody; KCT1 antibody; Keratinocytes associated transmembrane protein 1 antibody; OIT 2 antibody; OIT2 antibody; PRO 6241 antibody; PRO6241 antibody; RIC antibody
 Product Gene Name   

anti-FXYD5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    606669
 3D Structure    ModBase 3D Structure for Q96DB9
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
Section Bar
 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human Dysadherin (165-188aa KCRQLSRLCRNRCR).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Section Bar
 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FXYD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-FXYD5 antibody

   Description: Rabbit IgG polyclonal antibody for FXYD domain-containing ion transport regulator 5(FXYD5) detection. Tested with WB, IHC-P in Human.
Background: FXYD5(FXYD domain-containing ion transport regulator 5), also known as Dysadherin, is a protein that in humans is encoded by the FXYD5 gene. The gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The FXYD5 gene is mapped on 19q13.12. The deduced FXYD5 protein, the largest of the 7, contains 178 amino acids and has a signal peptide. Immunoreactivity for dysadherin, localized at cell-cell boundaries, was detected in 39 of 51 papillary carcinomas and in all 31 undifferentiated carcinomas but not in the follicular carcinomas or normal thyroid tissue controls. Dysadherin expression was significantly higher in undifferentiated carcinoma than in papillary carcinoma or follicular carcinoma and showed significant negative correlation with E-cadherin expression.
 Applications Tested/Suitable for anti-FXYD5 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Section Bar
 Western Blot (WB) of anti-FXYD5 antibody    Anti- FXYD5 antibody, MBS175496, Western blotting
All lanes: Anti FXYD5 (MBS175496) at 0.5ug/ml
WB: Rat PancreasTissue Lysate at 50ug
Predicted bind size: 19KD
Observed bind size: 19KD
anti-FXYD5 antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-FXYD5 antibody    Anti- FXYD5 antibody, MBS175496, IHC(P)
IHC(P): Human Mammary Cancer Tissue
anti-FXYD5 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for FXYD5. It may not necessarily be applicable to this product.
 NCBI GI #    311033386
 NCBI GeneID    53827
 NCBI Accession #    Q96DB9.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q96DB9 [Other Products]
 UniProt Secondary Accession #    Q6UW44; Q9HC34; Q9P039; B7WNZ8 [Other Products]
 UniProt Related Accession #    Q96DB9 [Other Products]
 Molecular Weight    11,888 Da
Table BarTOPTable Bar
 NCBI Official Full Name    FXYD domain-containing ion transport regulator 5
 NCBI Official Synonym Full Names    FXYD domain containing ion transport regulator 5
 NCBI Official Symbol    FXYD5 [Similar Products]
 NCBI Official Synonym Symbols   
RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241
[Similar Products]
 NCBI Protein Information    FXYD domain-containing ion transport regulator 5; dysadherin; keratinocytes associated transmembrane protein 1
 UniProt Protein Name    FXYD domain-containing ion transport regulator 5
 UniProt Synonym Protein Names   
Dysadherin
 Protein Family    FXYD domain-containing ion transport regulator
 UniProt Gene Name    FXYD5 [Similar Products]
 UniProt Synonym Gene Names    DYSAD; IWU1 [Similar Products]
 UniProt Entry Name    FXYD5_HUMAN
Section Bar
 NCBI Summary for FXYD5    This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
Section Bar
 UniProt Comments for FXYD5    FXYD5: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Belongs to the FXYD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Actin-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: integral to membrane

Molecular Function: cadherin binding; ion channel activity; actin binding

Biological Process: negative regulation of calcium-dependent cell-cell adhesion; microvillus biogenesis
Table BarTOPTable Bar
 Research Articles on FXYD5    1. we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-FXYD5 antibodyDiseases associated with anti-FXYD5 antibody
 Reference Product  PubMed Publications
 COX7A1 antibody  >6 publications with FXYD5 and COX7A1
 CDH1 antibody  >3 publications with FXYD5 and CDH1
 CFTR antibody  >1 publications with FXYD5 and CFTR
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with FXYD5 and Breast Neoplasms
 Lung Neoplasms Antibodies  >5 publications with FXYD5 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with FXYD5 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >3 publications with FXYD5 and Liver Neoplasms
 Hypertension Antibodies  >2 publications with FXYD5 and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with FXYD5 and Cardiovascular Diseases
 Liver Diseases Antibodies  >2 publications with FXYD5 and Liver Diseases
 Arteriosclerosis Antibodies  >1 publications with FXYD5 and Arteriosclerosis
 Hyperplasia Antibodies  >1 publications with FXYD5 and Hyperplasia
 Carcinoma, Hepatocellular Antibodies  >1 publications with FXYD5 and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-FXYD5 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >11 publications with FXYD5 and Kidney
 Lymph Antibodies  >10 publications with FXYD5 and Lymph
 Lymph Node Antibodies  >10 publications with FXYD5 and Lymph Node
 Lung Antibodies  >7 publications with FXYD5 and Lung
 Blood Antibodies  >6 publications with FXYD5 and Blood
 Muscle Antibodies  >6 publications with FXYD5 and Muscle
 Vascular Antibodies  >5 publications with FXYD5 and Vascular
 Liver Antibodies  >5 publications with FXYD5 and Liver
 Brain Antibodies  >3 publications with FXYD5 and Brain
 Stomach Antibodies  >3 publications with FXYD5 and Stomach
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions