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anti-XIAP antibody :: Rabbit anti-Human E3 ubiquitin-protein ligase XIAP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1494489
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E3 ubiquitin-protein ligase XIAP, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human E3 ubiquitin-protein ligase XIAP polyclonal Antibody(XIAP)

 Product Synonym Names    Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP; XIAP; API3; BIRC4; IAP3
 Product Gene Name   

anti-XIAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300079
 3D Structure    ModBase 3D Structure for P98170
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human E3 ubiquitin-protein ligase XIAP protein(1-200aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8789 / sc-8790 / sc-11426
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-XIAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-XIAP antibody

   Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
 Applications Tested/Suitable for anti-XIAP antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-XIAP antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-XIAP antibody    Western blot
All lanes: XIAP antibody at 3ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:MCF-7 whole cell lysate
Lane 3:PC-3 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 57kDa
Observed band size: 57kDa

anti-XIAP antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-XIAP antibody    Immunohistochemistry of paraffin-embedded human rectal cancer using MBS1494489 at dilution 1:100
anti-XIAP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-XIAP antibody    Immunohistochemistry of paraffin-embedded human melanoma using MBS1494489 at dilution 1:100
anti-XIAP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for XIAP. It may not necessarily be applicable to this product.
 NCBI GI #    32528299
 NCBI GeneID    331
 NCBI Accession #    NP_001158.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001167.3 [Other Products]
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 UniProt Primary Accession #    P98170 [Other Products]
 UniProt Secondary Accession #    Q9NQ14; D3DTF2 [Other Products]
 UniProt Related Accession #    P98170 [Other Products]
 Molecular Weight    56,685 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase XIAP
 NCBI Official Synonym Full Names    X-linked inhibitor of apoptosis
 NCBI Official Symbol    XIAP [Similar Products]
 NCBI Official Synonym Symbols   
API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase XIAP
 UniProt Protein Name    E3 ubiquitin-protein ligase XIAP
 UniProt Synonym Protein Names   
Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    XIAP [Similar Products]
 UniProt Synonym Gene Names    API3; BIRC4; IAP3; ILP; hILP; IAP-3; hIAP-3; hIAP3; X-linked IAP [Similar Products]
 UniProt Entry Name    XIAP_HUMAN
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 NCBI Summary for XIAP    This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
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 UniProt Comments for XIAP    Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
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 Research Articles on XIAP    1. The E3 ubiquitin ligase activity of XIAP and cIAP1 activates NFkappaB signalling, leading to the direct binding of p65 to the promoter of Beclin 1 and to its transcriptional activation and induction of autophagy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XIAP antibodyPathways associated with anti-XIAP antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >925 publications with XIAP and CASP3
 CASP9 antibody  >438 publications with XIAP and CASP9
 DIABLO antibody  >319 publications with XIAP and DIABLO
 CASP7 antibody  >86 publications with XIAP and CASP7
 HTRA2 antibody  >79 publications with XIAP and HTRA2
 APAF1 antibody  >62 publications with XIAP and APAF1
 TAB1 antibody  >12 publications with XIAP and TAB1
 UBC antibody  >4 publications with XIAP and UBC
 UBE2D1 antibody  >1 publications with XIAP and UBE2D1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Factor-mediated Response Pathway antibodies  Apoptotic Factor-mediated Response Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Deactivation Of The Beta-catenin Transactivating Complex Pathway antibodies  Deactivation Of The Beta-catenin Transactivating Complex Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-XIAP antibodyOrgans/Tissues associated with anti-XIAP antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >462 publications with XIAP and Necrosis
 Leukemia Antibodies  >390 publications with XIAP and Leukemia
 Nervous System Diseases Antibodies  >166 publications with XIAP and Nervous System Diseases
 Breast Neoplasms Antibodies  >118 publications with XIAP and Breast Neoplasms
 Liver Diseases Antibodies  >114 publications with XIAP and Liver Diseases
 Brain Diseases Antibodies  >112 publications with XIAP and Brain Diseases
 Inflammation Antibodies  >102 publications with XIAP and Inflammation
 Lung Neoplasms Antibodies  >102 publications with XIAP and Lung Neoplasms
 Liver Neoplasms Antibodies  >99 publications with XIAP and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >94 publications with XIAP and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >340 publications with XIAP and Blood
 Brain Antibodies  >178 publications with XIAP and Brain
 Liver Antibodies  >155 publications with XIAP and Liver
 Lung Antibodies  >150 publications with XIAP and Lung
 Prostate Antibodies  >120 publications with XIAP and Prostate
 Bone Antibodies  >100 publications with XIAP and Bone
 Vascular Antibodies  >85 publications with XIAP and Vascular
 Nerve Antibodies  >82 publications with XIAP and Nerve
 Muscle Antibodies  >73 publications with XIAP and Muscle
 Bone Marrow Antibodies  >62 publications with XIAP and Bone Marrow
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