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anti-EDNRB antibody :: Rabbit anti-Human, Mouse EDNRB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7048061
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EDNRB, Polyclonal Antibody

★Popular Item★
 Also Known As   

EDNRB Antibody

 Product Synonym Names    Endothelin B receptor; ET-B; ET-BR; Endothelin receptor non-selective type; EDNRB; ETRB
 Product Gene Name   

anti-EDNRB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M74921 mRNA
 3D Structure    ModBase 3D Structure for P24530
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Endothelin B receptor protein (27-442AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21195 / sc-21196 / sc-21197 / sc-21199 / sc-33537
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EDNRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EDNRB antibody

   Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
 Applications Tested/Suitable for anti-EDNRB antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-EDNRB antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-EDNRB antibody    Western Blot
Positive WB detected in: Mouse heart tissue,Mouse skeletal muscle tissue
All lanes: EDNRB antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50,49,60 KDa
Observed band size: 50 KDa

anti-EDNRB antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EDNRB antibody    Immunohistochemistry of paraffin-embedded human lung tissue using MBS7048061 at dilution of 1:100
anti-EDNRB antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-EDNRB antibody    Immunofluorescent analysis of PC3 cells using MBS7048061 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-EDNRB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EDNRB. It may not necessarily be applicable to this product.
 NCBI GI #    4557547
 NCBI GeneID    1910
 NCBI Accession #    NP_000106.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000115.4 [Other Products]
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 UniProt Primary Accession #    P24530 [Other Products]
 UniProt Secondary Accession #    O15343; Q59GB1; Q5W0G9; Q8NHM6; Q8NHM7; Q8NHM8; Q8NHM9; Q9UD23; Q9UQK3; A2A2Z8; A8K3T4 [Other Products]
 UniProt Related Accession #    P24530; AAB24922 [Other Products]
 Molecular Weight    59,480 Da
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 NCBI Official Full Name    endothelin B receptor isoform 1
 NCBI Official Synonym Full Names    endothelin receptor type B
 NCBI Official Symbol    EDNRB [Similar Products]
 NCBI Official Synonym Symbols   
ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2
[Similar Products]
 NCBI Protein Information    endothelin B receptor
 UniProt Protein Name    Endothelin B receptor
 UniProt Synonym Protein Names   
Endothelin receptor non-selective type
 Protein Family    Endothelin B receptor
 UniProt Gene Name    EDNRB [Similar Products]
 UniProt Synonym Gene Names    ETRB; ET-B; ET-BR [Similar Products]
 UniProt Entry Name    EDNRB_HUMAN
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 NCBI Summary for EDNRB    The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
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 UniProt Comments for EDNRB    ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: endothelin receptor activity; peptide hormone binding; protein binding

Biological Process: cell surface receptor linked signal transduction; enteric nervous system development; macrophage chemotaxis; negative regulation of adenylate cyclase activity; negative regulation of cellular protein metabolic process; negative regulation of neuron maturation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; vasoconstriction; vein smooth muscle contraction

Disease: Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2; Waardenburg Syndrome, Type 4a
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 Research Articles on EDNRB    1. Serum EDNRB hypermethylation is a highly specific but not sensitive serum biomarker for HNSCC
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EDNRB antibodyPathways associated with anti-EDNRB antibody
 Reference Product  PubMed Publications
 EDN3 antibody  >103 publications with EDNRB and EDN3
 SOX10 antibody  >64 publications with EDNRB and SOX10
 EDN1 antibody  >34 publications with EDNRB and EDN1
 EDN2 antibody  >15 publications with EDNRB and EDN2
 NOS3 antibody  >5 publications with EDNRB and NOS3
 GNA11 antibody  >2 publications with EDNRB and GNA11
 AGT antibody  >1 publications with EDNRB and AGT
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Endothelin Pathways antibodies  Endothelin Pathways Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with anti-EDNRB antibodyOrgans/Tissues associated with anti-EDNRB antibody
 Disease Name  Pubmed Publications
 Hirschsprung Disease Antibodies  >162 publications with EDNRB and Hirschsprung Disease
 Disease Models, Animal Antibodies  >46 publications with EDNRB and Disease Models, Animal
 Inflammation Antibodies  >12 publications with EDNRB and Inflammation
 Cardiovascular Diseases Antibodies  >12 publications with EDNRB and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >10 publications with EDNRB and Adenocarcinoma
 Hypertension Antibodies  >9 publications with EDNRB and Hypertension
 Lung Diseases Antibodies  >9 publications with EDNRB and Lung Diseases
 WAARDENBURG SYNDROME, TYPE 4A Antibodies  >8 publications with EDNRB and WAARDENBURG SYNDROME, TYPE 4A
 Neoplasms, Experimental Antibodies  >8 publications with EDNRB and Neoplasms, Experimental
 Kidney Diseases Antibodies  >6 publications with EDNRB and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >51 publications with EDNRB and Intestine
 Brain Antibodies  >24 publications with EDNRB and Brain
 Embryonic Tissue Antibodies  >23 publications with EDNRB and Embryonic Tissue
 Eye Antibodies  >20 publications with EDNRB and Eye
 Lung Antibodies  >14 publications with EDNRB and Lung
 Heart Antibodies  >9 publications with EDNRB and Heart
 Placenta Antibodies  >5 publications with EDNRB and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with EDNRB and Uncharacterized Tissue
 Pancreas Antibodies  >1 publications with EDNRB and Pancreas
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