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anti-EFNA1 antibody :: Rabbit EFNA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9126040
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EFNA1, Polyclonal Antibody

 Also Known As   

EFNA1 Polyclonal Antibody

 Product Synonym Names    B61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4
 Product Gene Name   

anti-EFNA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191164
 3D Structure    ModBase 3D Structure for P20827
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human EFNA1
 Calculated Molecular Weight    24kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-EFNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EFNA1 antibody

   This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.
 Product Categories/Family for anti-EFNA1 antibody    Polyclonal
 Applications Tested/Suitable for anti-EFNA1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-EFNA1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-EFNA1 antibody    Western blot analysis of extracts of various cell lines, using EFNA1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
anti-EFNA1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EFNA1 antibody    Immunohistochemistry of paraffin-embedded human prostate using EFNA1 Antibody at dilution of 1:100 (40x lens).
anti-EFNA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-EFNA1 antibody    Immunohistochemistry of paraffin-embedded human esophagus using EFNA1 Antibody at dilution of 1:100 (40x lens).
anti-EFNA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-EFNA1 antibody    Immunohistochemistry of paraffin-embedded mouse lung using EFNA1 Antibody at dilution of 1:100 (40x lens).
anti-EFNA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-EFNA1 antibody    Immunohistochemistry of paraffin-embedded mouse stomach using EFNA1 Antibody at dilution of 1:100 (40x lens).
anti-EFNA1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EFNA1. It may not necessarily be applicable to this product.
 NCBI GI #    73920206
 NCBI GeneID    1942
 NCBI Accession #    P20827.2 [Other Products]
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 UniProt Primary Accession #    P20827 [Other Products]
 UniProt Secondary Accession #    Q5SR60; Q5SR61; Q6I9T9; Q8N578; D3DV86 [Other Products]
 UniProt Related Accession #    P20827 [Other Products]
 Molecular Weight    205
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 NCBI Official Full Name    Ephrin-A1
 NCBI Official Synonym Full Names    ephrin-A1
 NCBI Official Symbol    EFNA1 [Similar Products]
 NCBI Official Synonym Symbols   
B61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4
[Similar Products]
 NCBI Protein Information    ephrin-A1; TNF alpha-induced protein 4; ligand of eph-related kinase 1; immediate early response protein B61; eph-related receptor tyrosine kinase ligand 1; tumor necrosis factor alpha-induced protein 4; tumor necrosis factor, alpha-induced protein 4
 UniProt Protein Name    Ephrin-A1
 UniProt Synonym Protein Names   
EPH-related receptor tyrosine kinase ligand 1; LERK-1; Immediate early response protein B61; Tumor necrosis factor alpha-induced protein 4; TNF alpha-induced protein 4
 Protein Family    Ephrin
 UniProt Gene Name    EFNA1 [Similar Products]
 UniProt Synonym Gene Names    EPLG1; LERK1; TNFAIP4; LERK-1; TNF alpha-induced protein 4 [Similar Products]
 UniProt Entry Name    EFNA1_HUMAN
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 NCBI Summary for EFNA1    This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EFNA1    EFNA1: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. Belongs to the ephrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Ligand, receptor tyrosine kinase; Tumor suppressor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: anchored to plasma membrane; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; ephrin receptor binding; receptor binding

Biological Process: axon guidance; cell migration; activation of MAPK activity; notochord formation; negative regulation of transcription from RNA polymerase II promoter; regulation of blood vessel endothelial cell migration; regulation of axonogenesis; regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell adhesion mediated by integrin; cell-cell signaling; ephrin receptor signaling pathway; angiogenesis; regulation of peptidyl-tyrosine phosphorylation
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 Research Articles on EFNA1    1. Results suggest that EFNA1 is involved in colorectal tumorigenesis, and rs12904 A>G polymorphism in the 3' UTR of EFNA1 is associated with CRC susceptibility in a Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EFNA1 antibodyPathways associated with anti-EFNA1 antibody
 Reference Product  PubMed Publications
 EPHA2 antibody  >15 publications with EFNA1 and EPHA2
 EPHA1 antibody  >4 publications with EFNA1 and EPHA1
 EPHB6 antibody  >2 publications with EFNA1 and EPHB6
 EPHA3 antibody  >2 publications with EFNA1 and EPHA3
 EPHA6 antibody  >1 publications with EFNA1 and EPHA6
 EPHA4 antibody  >1 publications with EFNA1 and EPHA4
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 EPHA-mediated Growth Cone Collapse Pathway antibodies  EPHA-mediated Growth Cone Collapse Pathway Diagram
 EPHA2 Forward Signaling Pathway antibodies  EPHA2 Forward Signaling Pathway Diagram
Diseases associated with anti-EFNA1 antibodyOrgans/Tissues associated with anti-EFNA1 antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >3 publications with EFNA1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >3 publications with EFNA1 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with EFNA1 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >2 publications with EFNA1 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with EFNA1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with EFNA1 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >2 publications with EFNA1 and Breast Neoplasms
 Cholestasis Antibodies  >1 publications with EFNA1 and Cholestasis
 Fibrosis Antibodies  >1 publications with EFNA1 and Fibrosis
 Colonic Neoplasms Antibodies  >1 publications with EFNA1 and Colonic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with EFNA1 and Blood
 Liver Antibodies  >5 publications with EFNA1 and Liver
 Bone Antibodies  >4 publications with EFNA1 and Bone
 Vascular Antibodies  >4 publications with EFNA1 and Vascular
 Prostate Antibodies  >3 publications with EFNA1 and Prostate
 Lung Antibodies  >3 publications with EFNA1 and Lung
 Brain Antibodies  >3 publications with EFNA1 and Brain
 Stomach Antibodies  >2 publications with EFNA1 and Stomach
 Embryonic Tissue Antibodies  >2 publications with EFNA1 and Embryonic Tissue
 Intestine Antibodies  >2 publications with EFNA1 and Intestine
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