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anti-EIF2B4 antibody :: Goat EIF2B4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422421
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EIF2B4, Polyclonal Antibody

 Also Known As   

Goat anti-EIF2B4 Antibody

 Product Synonym Names    EIF2B4; eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; DKFZp586J0119; EIF-2B; EIF2B; EIF2Bdelta; eIF-2B GDP-GTP exchange factor subunit delta; eukaryotic translation initiation factor 2B, subunit 4 delta; translation initiation facto; DKFZp586J0119 antibody; EIF2B antibody; EIF-2B antibody; eIF-2B GDP-GTP exchange factor subunit delta antibody; EIF2Bdelta antibody; eukaryotic translation initiation factor 2B; subunit 4 delta antibody; eukaryotic translation initiation factor 2B; subunit 4 delta; 67kDa antibody; translation initiation facto antibody; EIF2B4 antibody
 Product Gene Name   

anti-EIF2B4 antibody

[Similar Products]
 Antibody/Peptide Pairs    EIF2B4 peptide (MBS427285) is used for blocking the activity of EIF2B4 antibody (MBS422421)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RKDYGSKVSL FSH
 OMIM    603896
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Rabbit
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RKDYGSKVSLFSH, from the internal region of the protein sequence according to NP_751945.2; NP_001029288.1; NP_056451.3.
 Epitope    Internal region
 Note    This antibody is expected to recognize all reported isoforms (NP_751945.2; NP_001029288.1; NP_056451.3).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-EIF2B4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EIF2B4 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-EIF2B4 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
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 Western Blot (WB) of anti-EIF2B4 antibody    (0.3ug/ml) staining of K562 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-EIF2B4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for EIF2B4. It may not necessarily be applicable to this product.
 NCBI GI #    187607323
 NCBI GeneID    8890
 NCBI Accession #    NP_751945.2 [Other Products]
 NCBI Related Accession #    NP_001029288.1; NP_056451.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_172195.3 [Other Products]
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 UniProt Secondary Accession #    Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UIQ9; Q9UJ95 [Other Products]
 UniProt Related Accession #    Q9UI10 [Other Products]
 Molecular Weight    57,458 Da
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 NCBI Official Full Name    translation initiation factor eIF-2B subunit delta isoform 1
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 2B subunit delta
 NCBI Official Symbol    EIF2B4 [Similar Products]
 NCBI Official Synonym Symbols   
EIF2B; EIF-2B; EIF2Bdelta
[Similar Products]
 NCBI Protein Information    translation initiation factor eIF-2B subunit delta
 UniProt Protein Name    Translation initiation factor eIF-2B subunit delta
 UniProt Synonym Protein Names   
eIF-2B GDP-GTP exchange factor subunit delta
 Protein Family    Translation initiation factor
 UniProt Gene Name    EIF2B4 [Similar Products]
 UniProt Synonym Gene Names    EIF2BD [Similar Products]
 UniProt Entry Name    EI2BD_HUMAN
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 NCBI Summary for EIF2B4    Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EIF2B4    eIF2B-delta: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation initiation; Motility/polarity/chemotaxis; Translation

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity; translation initiation factor activity; translation initiation factor binding

Biological Process: cellular response to stimulus; methionine salvage; myelination; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; oligodendrocyte development; ovarian follicle development; positive regulation of GTPase activity; regulation of translation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation

Disease: Leukoencephalopathy With Vanishing White Matter
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 Research Articles on EIF2B4    1. demonstrate that DAP5 associates with eIF2beta and eIF4AI to stimulate IRES-dependent translation of cellular mRNAs
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-EIF2B4 antibodyDiseases associated with anti-EIF2B4 antibody
 Products by Pathway  Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Recycling Of EIF2:GDP Pathway antibodies  Recycling Of EIF2:GDP Pathway Diagram
 Translation Pathway antibodies  Translation Pathway Diagram
 Translation Factors Pathway antibodies  Translation Factors Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with EIF2B4 and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >4 publications with EIF2B4 and Neurodegenerative Diseases
 Atrophy Antibodies  >4 publications with EIF2B4 and Atrophy
 Brain Diseases Antibodies  >4 publications with EIF2B4 and Brain Diseases
 Seizures Antibodies  >2 publications with EIF2B4 and Seizures
 Death Antibodies  >1 publications with EIF2B4 and Death
 Necrosis Antibodies  >1 publications with EIF2B4 and Necrosis
Organs/Tissues associated with anti-EIF2B4 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with EIF2B4 and Brain
 Blood Antibodies  >1 publications with EIF2B4 and Blood
 Lung Antibodies  >1 publications with EIF2B4 and Lung
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