NP_115657.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ELAV-like protein 3 isoform 2
NCBI Official Synonym Full Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
NCBI Protein Information
ELAV-like protein 3; Hu antigen C; hu-antigen C; paraneoplastic limbic encephalitis antigen 21; paraneoplastic cerebellar degeneration-associated antigen
UniProt Protein Name
ELAV-like protein 3
UniProt Synonym Protein Names
Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21
UniProt Synonym Gene Names
UniProt Entry Name
ELAV3_HUMAN
NCBI Summary for ELAVL3
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ELAVL3
ELAVL3: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19p13.2
Molecular Function: nucleotide binding; AU-rich element binding
Biological Process: nervous system development; cell differentiation
Research Articles on ELAVL3
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Products associated with anti-ELAVL3 antibody
Diseases associated with anti-ELAVL3 antibody
Organs/Tissues associated with anti-ELAVL3 antibody
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