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anti-ELF3 antibody :: Goat ELF3/ERT/ ESX Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420518
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ELF3/ERT/ ESX, Polyclonal Antibody

 Also Known As   

Goat anti-ELF3/ERT/ ESX Antibody

 Product Synonym Names    ELF3; ERT; E74-like factor 3 (ets domain transcription factor, epithelial-specific); EPR-1; ESE-1; E74-like factor 3 (ets domain transcription factor); ets domain transcription factor, serine box (epithelial-specific); E74-like factor 3 (ETS domain trans; ELF3 antibody; ERT antibody; E74-like factor 3 (ets domain transcription factor; epithelial-specific) antibody; EPR-1 antibody; ESE-1 antibody; E74-like factor 3 (ets domain transcription factor) antibody; ets domain transcription factor; serine box (epithelial-specific) antibody; E74-like factor 3 (ETS domain transcription factor; serine box; epithelial-specific) antibody; ELF3 / ERT/ ESX
 Product Gene Name   

anti-ELF3 antibody

[Similar Products]
 Product Synonym Gene Name    ERT; ESX [Similar Products]
 Antibody/Peptide Pairs    ELF3 / ERT/ ESX peptide (MBS425141) is used for blocking the activity of ELF3/ERT/ ESX antibody (MBS420518)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SGWKEEEVLQ SRN
 OMIM    602191
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SGWKEEEVLQSRN, from the C Terminus of the protein sequence according to NP_004424.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ELF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ELF3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ELF3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 48 kDa band observed in NCI-H460 lysate (calculated MW of 41.5kDa according to NP_004424.2). In transfected HEK293 transiently expressing ELF3 a band of approx. 40kDa is observed. This band is not observed in the non-transfected HEK293. Recommended for use at 2-4ug/ml.
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 Western Blot (WB) of anti-ELF3 antibody    Staining (3ug/ml) of NCI-H460 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-ELF3 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ELF3 antibody    HEK293 overexpressing ELF3 (RC200631) and probed (mock transfection in first lane), tested by Origene.
anti-ELF3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ELF3. It may not necessarily be applicable to this product.
 NCBI GI #    40255035
 NCBI GeneID    1999
 NCBI Accession #    NP_004424.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004433.3 [Other Products]
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 UniProt Secondary Accession #    Q6IAP8; Q7RU03; Q7Z3X2; Q8NFG2; Q99718; B2R5Q6 [Other Products]
 UniProt Related Accession #    P78545 [Other Products]
 Molecular Weight    39,357 Da
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 NCBI Official Full Name    E74-like factor 3 (ets domain transcription factor, epithelial-specific)
 NCBI Official Synonym Full Names    E74 like ETS transcription factor 3
 NCBI Official Symbol    ELF3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ETS-related transcription factor Elf-3
 UniProt Protein Name    ETS-related transcription factor Elf-3
 UniProt Synonym Protein Names   
E74-like factor 3; Epithelial-restricted with serine box; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; ESE-1
 Protein Family    ETS-related transcription factor
 UniProt Gene Name    ELF3 [Similar Products]
 UniProt Synonym Gene Names    ESE-1 [Similar Products]
 UniProt Entry Name    ELF3_HUMAN
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 UniProt Comments for ELF3    ELF3: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; transcription coactivator activity; transcription factor activity

Biological Process: blastocyst development; epidermis development; epithelial cell differentiation; extracellular matrix organization and biogenesis; inflammatory response; mammary gland involution; multicellular organismal development; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
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 Research Articles on ELF3    1. our data suggested that ESE1/ELF3 may promote the UC progression via accelerating NF-kappaB activation and thus facilitating IEC apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ELF3 antibodyDiseases associated with anti-ELF3 antibody
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >17 publications with ELF3 and Breast Neoplasms
 Inflammation Antibodies  >16 publications with ELF3 and Inflammation
 Adenocarcinoma Antibodies  >11 publications with ELF3 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >8 publications with ELF3 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >6 publications with ELF3 and Necrosis
 Lung Neoplasms Antibodies  >6 publications with ELF3 and Lung Neoplasms
 Lung Diseases Antibodies  >5 publications with ELF3 and Lung Diseases
 Fibrosis Antibodies  >5 publications with ELF3 and Fibrosis
 Neoplasm Metastasis Antibodies  >4 publications with ELF3 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >4 publications with ELF3 and Neoplasms, Experimental
Organs/Tissues associated with anti-ELF3 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >13 publications with ELF3 and Lung
 Mammary Gland Antibodies  >12 publications with ELF3 and Mammary Gland
 Prostate Antibodies  >12 publications with ELF3 and Prostate
 Embryonic Tissue Antibodies  >11 publications with ELF3 and Embryonic Tissue
 Intestine Antibodies  >11 publications with ELF3 and Intestine
 Kidney Antibodies  >9 publications with ELF3 and Kidney
 Liver Antibodies  >7 publications with ELF3 and Liver
 Stomach Antibodies  >7 publications with ELF3 and Stomach
 Muscle Antibodies  >6 publications with ELF3 and Muscle
 Bladder Antibodies  >5 publications with ELF3 and Bladder
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