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anti-ELOVL4 antibody :: Rabbit ELOVL4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS128964
Western Blot (WB)
Unit / Price
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ELOVL4, Polyclonal Antibody

★Popular Item★
 Also Known As   

ELOVL4 Polyclonal Antibody

 Product Synonym Names    ADMD; CT118; ISQMR; STGD2; STGD3
 Product Gene Name   

anti-ELOVL4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614457
 3D Structure    ModBase 3D Structure for Q9GZR5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A synthetic peptide of human ELOVL4
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 Preparation and Storage    Store at 4 degree C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
 Other Notes    Small volumes of anti-ELOVL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ELOVL4 antibody

   This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration.
 Product Categories/Family for anti-ELOVL4 antibody    Polyclonal
 Applications Tested/Suitable for anti-ELOVL4 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ELOVL4 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-ELOVL4 antibody    Western blot analysis of extracts of Y79 cell line, using ELOVL4 antibody.
anti-ELOVL4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ELOVL4. It may not necessarily be applicable to this product.
 NCBI GI #    20137966
 NCBI GeneID    6785
 NCBI Accession #    Q9GZR5.1 [Other Products]
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 UniProt Primary Accession #    Q9GZR5 [Other Products]
 UniProt Secondary Accession #    Q5TCS2; Q86YJ1; Q9H139; B2R6B5 [Other Products]
 UniProt Related Accession #    Q9GZR5 [Other Products]
 Molecular Weight    37kDa
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 NCBI Official Full Name    Elongation of very long chain fatty acids protein 4
 NCBI Official Synonym Full Names    ELOVL fatty acid elongase 4
 NCBI Official Symbol    ELOVL4 [Similar Products]
 NCBI Official Synonym Symbols   
ADMD; CT118; ISQMR; SCA34; STGD2; STGD3
[Similar Products]
 NCBI Protein Information    elongation of very long chain fatty acids protein 4; ELOVL FA elongase 4; cancer/testis antigen 118; 3-keto acyl-CoA synthase ELOVL4; very-long-chain 3-oxoacyl-CoA synthase 4; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
 UniProt Protein Name    Elongation of very long chain fatty acids protein 4
 UniProt Synonym Protein Names   
3-keto acyl-CoA synthase ELOVL4; ELOVL fatty acid elongase 4; ELOVL FA elongase 4; Very-long-chain 3-oxoacyl-CoA synthase 4
 Protein Family    Elongation of very long chain fatty acids protein
 UniProt Gene Name    ELOVL4 [Similar Products]
 UniProt Synonym Gene Names    ELOVL FA elongase 4 [Similar Products]
 UniProt Entry Name    ELOV4_HUMAN
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 NCBI Summary for ELOVL4    This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ELOVL4    ELOVL4: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development. Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant. Defects in ELOVL4 are the cause of ichthyosis, spastic quadriplegia, and mental retardation (ISQMR). A severe autosomal recessive disorder characterized by ichthyosis apparent from birth, profound psychomotor retardation with essentially no development, spastic quadriplegia, and seizures. Belongs to the ELO family.

Protein type: Cancer Testis Antigen (CTA); Membrane protein, multi-pass; Endoplasmic reticulum; EC 2.3.1.199; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: transferase activity; protein binding; G-protein coupled photoreceptor activity

Biological Process: very-long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid elongation, saturated fatty acid; fatty acid biosynthetic process; detection of visible light

Disease: Spinocerebellar Ataxia 34
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 Research Articles on ELOVL4    1. We propose that transgenic expression of ELOVL4 in the liver will result in the biosynthesis of very long chain-PUFA that can be transported to target.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ELOVL4 antibodyPathways associated with anti-ELOVL4 antibody
 Reference Product  PubMed Publications
 ABCA4 antibody  >10 publications with ELOVL4 and ABCA4
 EFEMP1 antibody  >6 publications with ELOVL4 and EFEMP1
 CFH antibody  >5 publications with ELOVL4 and CFH
 HMCN1 antibody  >1 publications with ELOVL4 and HMCN1
 PLEKHA1 antibody  >1 publications with ELOVL4 and PLEKHA1
 CNGB3 antibody  >1 publications with ELOVL4 and CNGB3
 Products by Pathway  Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis Of Very Long-chain Fatty Acyl-CoAs Pathway antibodies  Synthesis Of Very Long-chain Fatty Acyl-CoAs Pathway Diagram
 Triglyceride Biosynthesis Pathway antibodies  Triglyceride Biosynthesis Pathway Diagram
Diseases associated with anti-ELOVL4 antibodyOrgans/Tissues associated with anti-ELOVL4 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >24 publications with ELOVL4 and Disease Models, Animal
 Stargardt disease 3 Antibodies  >18 publications with ELOVL4 and Stargardt disease 3
 Nervous System Diseases Antibodies  >6 publications with ELOVL4 and Nervous System Diseases
 Fatty Liver Antibodies  >5 publications with ELOVL4 and Fatty Liver
 Nerve Degeneration Antibodies  >5 publications with ELOVL4 and Nerve Degeneration
 Inflammation Antibodies  >3 publications with ELOVL4 and Inflammation
 Adenocarcinoma Antibodies  >3 publications with ELOVL4 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >2 publications with ELOVL4 and Cardiovascular Diseases
 Abnormalities, Multiple Antibodies  >2 publications with ELOVL4 and Abnormalities, Multiple
 Mitochondrial Diseases Antibodies  >1 publications with ELOVL4 and Mitochondrial Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >91 publications with ELOVL4 and Eye
 Skin Antibodies  >16 publications with ELOVL4 and Skin
 Brain Antibodies  >11 publications with ELOVL4 and Brain
 Liver Antibodies  >6 publications with ELOVL4 and Liver
 Testis Antibodies  >4 publications with ELOVL4 and Testis
 Vascular Antibodies  >4 publications with ELOVL4 and Vascular
 Kidney Antibodies  >4 publications with ELOVL4 and Kidney
 Embryonic Tissue Antibodies  >2 publications with ELOVL4 and Embryonic Tissue
 Muscle Antibodies  >2 publications with ELOVL4 and Muscle
 Heart Antibodies  >1 publications with ELOVL4 and Heart
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