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anti-ELOVL4 antibody :: Rabbit anti-Human, Rat ELOVL4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051324
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ELOVL4, Polyclonal Antibody

★Popular Item★
 Also Known As   

ELOVL4 Antibody

 Product Synonym Names    Elongation of very long chain fatty acids protein 4; 3-keto acyl-CoA synthase ELOVL4; ELOVL4
 Product Gene Name   

anti-ELOVL4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF279654
 3D Structure
   ModBase 3D Structure for Q9GZR5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Elongation of very long chain fatty acids protein 4 protein (270-314AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49192 / sc-49193 / sc-67215
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ELOVL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ELOVL4 antibody

   Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24: 0 and C26: 0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
 Applications Tested/Suitable for anti-ELOVL4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ELOVL4 antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-ELOVL4 antibody    Western Blot
Positive WB detected in: HepG2 whole cell lysate,Rat heart tissue,Rat liver tissue
All lanes: ELOVL4 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 37 KDa
Observed band size: 37 KDa

anti-ELOVL4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ELOVL4 antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7051324 at dilution of 1:100
anti-ELOVL4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ELOVL4 antibody    Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7051324 at dilution of 1:100
anti-ELOVL4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ELOVL4 antibody    Immunofluorescent analysis of HepG2 cells using MBS7051324 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ELOVL4 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ELOVL4. It may not necessarily be applicable to this product.
 NCBI GI #    12232379
 NCBI GeneID    6785
 NCBI Accession #    NP_073563.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022726.3 [Other Products]
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 UniProt Primary Accession #    Q9GZR5 [Other Products]
 UniProt Secondary Accession #    Q5TCS2; Q86YJ1; Q9H139; B2R6B5 [Other Products]
 UniProt Related Accession #    Q9GZR5 [Other Products]
 Molecular Weight    36,829 Da
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 NCBI Official Full Name    elongation of very long chain fatty acids protein 4
 NCBI Official Synonym Full Names    ELOVL fatty acid elongase 4
 NCBI Official Symbol    ELOVL4 [Similar Products]
 NCBI Official Synonym Symbols   
ADMD; CT118; ISQMR; SCA34; STGD2; STGD3
[Similar Products]
 NCBI Protein Information    elongation of very long chain fatty acids protein 4
 UniProt Protein Name    Elongation of very long chain fatty acids protein 4
 UniProt Synonym Protein Names   
3-keto acyl-CoA synthase ELOVL4
 Protein Family    Elongation of very long chain fatty acids protein
 UniProt Gene Name    ELOVL4 [Similar Products]
 UniProt Synonym Gene Names    ELOVL FA elongase 4 [Similar Products]
 UniProt Entry Name    ELOV4_HUMAN
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 NCBI Summary for ELOVL4    This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ELOVL4    ELOVL4: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development. Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant. Defects in ELOVL4 are the cause of ichthyosis, spastic quadriplegia, and mental retardation (ISQMR). A severe autosomal recessive disorder characterized by ichthyosis apparent from birth, profound psychomotor retardation with essentially no development, spastic quadriplegia, and seizures. Belongs to the ELO family.

Protein type: Cancer Testis Antigen (CTA); EC 2.3.1.199; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: fatty acid elongase activity; protein binding

Biological Process: fatty acid elongation, saturated fatty acid; sphingolipid biosynthetic process; very-long-chain fatty acid biosynthetic process

Disease: Spinocerebellar Ataxia 34
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 Research Articles on ELOVL4    1. In patients with intrahepatic cholestasis of pregnancy, there was no elevation in ELOVL4 mRNA in maternal circulation compared with controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ELOVL4 antibodyPathways associated with anti-ELOVL4 antibody
 Reference Product  PubMed Publications
 ABCA4 antibody  >12 publications with ELOVL4 and ABCA4
 HMCN1 antibody  >1 publications with ELOVL4 and HMCN1
 PLEKHA1 antibody  >1 publications with ELOVL4 and PLEKHA1
 ARMS2 antibody  >1 publications with ELOVL4 and ARMS2
 IMPG1 antibody  >1 publications with ELOVL4 and IMPG1
 Products by Pathway  Pathway Diagram
 Ectoderm Differentiation Pathway antibodies  Ectoderm Differentiation Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis Of Very Long-chain Fatty Acyl-CoAs Pathway antibodies  Synthesis Of Very Long-chain Fatty Acyl-CoAs Pathway Diagram
Diseases associated with anti-ELOVL4 antibodyOrgans/Tissues associated with anti-ELOVL4 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >29 publications with ELOVL4 and Disease Models, Animal
 Stargardt disease 3 Antibodies  >20 publications with ELOVL4 and Stargardt disease 3
 Fatty Liver Antibodies  >7 publications with ELOVL4 and Fatty Liver
 Nerve Degeneration Antibodies  >5 publications with ELOVL4 and Nerve Degeneration
 Adenocarcinoma Antibodies  >4 publications with ELOVL4 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >3 publications with ELOVL4 and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with ELOVL4 and Inflammation
 Abnormalities, Multiple Antibodies  >2 publications with ELOVL4 and Abnormalities, Multiple
 Kidney Diseases Antibodies  >1 publications with ELOVL4 and Kidney Diseases
 Weight Gain Antibodies  >1 publications with ELOVL4 and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >103 publications with ELOVL4 and Eye
 Skin Antibodies  >20 publications with ELOVL4 and Skin
 Brain Antibodies  >14 publications with ELOVL4 and Brain
 Liver Antibodies  >9 publications with ELOVL4 and Liver
 Testis Antibodies  >6 publications with ELOVL4 and Testis
 Vascular Antibodies  >4 publications with ELOVL4 and Vascular
 Kidney Antibodies  >4 publications with ELOVL4 and Kidney
 Embryonic Tissue Antibodies  >2 publications with ELOVL4 and Embryonic Tissue
 Muscle Antibodies  >2 publications with ELOVL4 and Muscle
 Heart Antibodies  >1 publications with ELOVL4 and Heart
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