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anti-EMD antibody :: Rabbit EMD / Emerin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240356
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EMD / Emerin, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human EMD / Emerin

 Product Synonym Names    Anti-EMD / Emerin Antibody (N-Terminus) IHC-plus; EMD; EDMD; Emerin; LEM domain containing 5; LEMD5; STA; Human EMD; Emerin
 Product Gene Name   

anti-EMD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 310300
 3D Structure    ModBase 3D Structure for P50402
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    19 amino acid peptide from near the amino terminus of human Emerin.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human EMD.
 Immunogen Type    Synthetic peptide
 Immunogen    EMD / Emerin antibody was raised against synthetic peptide from human EMD.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-EMD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EMD antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-EMD antibody    IHC-P (2.5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-EMD antibody    Anti-EMD / Emerin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-EMD antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-EMD antibody    Immunofluorescence of Emerin in Human Skeletal Muscle cells with Emerin antibody at 5 ug/ml.
anti-EMD antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-EMD antibody    Western blot of Emerin in human skeletal muscle tissue lysate with Emerin antibody at (A) 0.5 and (B) 1 ug/ml.
anti-EMD antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for EMD. It may not necessarily be applicable to this product.
 NCBI GI #    4557553
 NCBI GeneID    2010
 NCBI Accession #    NP_000108.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000117.2 [Other Products]
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 UniProt Primary Accession #    P50402 [Other Products]
 UniProt Secondary Accession #    Q6FI02 [Other Products]
 UniProt Related Accession #    P50402 [Other Products]
 Molecular Weight    28,994 Da
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 NCBI Official Full Name    emerin
 NCBI Official Synonym Full Names    emerin
 NCBI Official Symbol    EMD [Similar Products]
 NCBI Official Synonym Symbols   
STA; EDMD; LEMD5
[Similar Products]
 NCBI Protein Information    emerin; LEM domain containing 5
 UniProt Protein Name    Emerin
 Protein Family    Emerin
 UniProt Gene Name    EMD [Similar Products]
 UniProt Synonym Gene Names    EDMD; STA [Similar Products]
 UniProt Entry Name    EMD_HUMAN
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 NCBI Summary for EMD    Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EMD    emerin: a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.

Protein type: Cytoskeletal; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: nuclear outer membrane; microtubule; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear inner membrane; nuclear envelope

Molecular Function: protein binding; beta-tubulin binding; actin binding

Biological Process: positive regulation of protein export from nucleus; muscle development; mitotic nuclear envelope reassembly; muscle contraction; negative regulation of fibroblast proliferation; mitotic nuclear envelope disassembly; mitotic cell cycle

Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked
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 Research Articles on EMD    1. Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EMD antibodyPathways associated with anti-EMD antibody
 Reference Product  PubMed Publications
 LMNA antibody  >17 publications with EMD and LMNA
 SYNE2 antibody  >2 publications with EMD and SYNE2
 SRC antibody  >2 publications with EMD and SRC
 SYNE1 antibody  >2 publications with EMD and SYNE1
 ERBB2 antibody  >1 publications with EMD and ERBB2
 ACTB antibody  >1 publications with EMD and ACTB
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Clearance Of Nuclear Envelope Membranes From Chromatin Pathway antibodies  Clearance Of Nuclear Envelope Membranes From Chromatin Pathway Diagram
 Depolymerisation Of The Nuclear Lamina Pathway antibodies  Depolymerisation Of The Nuclear Lamina Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Diseases associated with anti-EMD antibodyOrgans/Tissues associated with anti-EMD antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >240 publications with EMD and Heart Diseases
 Nervous System Diseases Antibodies  >162 publications with EMD and Nervous System Diseases
 Muscular Diseases Antibodies  >55 publications with EMD and Muscular Diseases
 Death Antibodies  >50 publications with EMD and Death
 Muscular Dystrophy, Emery-Dreifuss Antibodies  >49 publications with EMD and Muscular Dystrophy, Emery-Dreifuss
 Inflammation Antibodies  >42 publications with EMD and Inflammation
 Necrosis Antibodies  >30 publications with EMD and Necrosis
 Hemorrhage Antibodies  >30 publications with EMD and Hemorrhage
 Hypertrophy Antibodies  >20 publications with EMD and Hypertrophy
 Neoplasm Metastasis Antibodies  >12 publications with EMD and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >372 publications with EMD and Bone
 Heart Antibodies  >367 publications with EMD and Heart
 Muscle Antibodies  >333 publications with EMD and Muscle
 Blood Antibodies  >269 publications with EMD and Blood
 Brain Antibodies  >175 publications with EMD and Brain
 Connective Tissue Antibodies  >109 publications with EMD and Connective Tissue
 Vascular Antibodies  >92 publications with EMD and Vascular
 Eye Antibodies  >64 publications with EMD and Eye
 Skin Antibodies  >55 publications with EMD and Skin
 Liver Antibodies  >54 publications with EMD and Liver
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