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anti-EML1 antibody :: Rabbit EML1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS768988
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EML1, Polyclonal Antibody

★Popular Item★
 Also Known As   

EML1 Rabbit Polyclonal

 Product Synonym Names    EML1, EMAP1, EMAP, ELP79, EMAPL1
 Product Gene Name   

anti-EML1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS768988 Technical Datasheet    Technical Datasheet PDF
 OMIM    602033
 3D Structure    ModBase 3D Structure for O00423
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    human, Mouse, rat; other species are not tested. Please decide the specificity by homology
 Purity/Purification    Purity: >=95% as determined by SDS-PAGE
Purification: Immunogen Affinity Purified
 Form/Format    Liquid
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 Calculated MW    90kD
 Immunogen    Echinoderm microtubule associated protein like 1
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
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 Preparation and Storage    -20C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EML1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EML1 antibody

   Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se (By similarity).
 Applications Tested/Suitable for anti-EML1 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-EML1 antibody    WB : 1:500-1:2000
IF : 1:10-1:100
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 Immunofluorescent of anti-EML1 antibody    Immunofluorescent analysis of HepG2 cells, using EML1 antibody MBS768988 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
anti-EML1 antibody Immunofluorescent image
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 SDS-PAGE of anti-EML1 antibody    HepG2 cells were subjected to SDS PAGE followed by western blot with MBS768988 (EML1 antibody) at dilution of 1:300
anti-EML1 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for EML1. It may not necessarily be applicable to this product.
 NCBI GI #    56790932
 NCBI GeneID    2009
 NCBI Accession #    NP_001008707.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008707.1 [Other Products]
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 UniProt Primary Accession #    O00423 [Other Products]
 UniProt Secondary Accession #    Q86U15; Q8N536; Q8N5C4; Q8WWL6 [Other Products]
 UniProt Related Accession #    O00423 [Other Products]
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 NCBI Official Full Name    echinoderm microtubule-associated protein-like 1 isoform a
 NCBI Official Synonym Full Names    echinoderm microtubule associated protein like 1
 NCBI Official Symbol    EML1 [Similar Products]
 NCBI Official Synonym Symbols   
EMAP; ELP79; EMAPL; HuEMAP
[Similar Products]
 NCBI Protein Information    echinoderm microtubule-associated protein-like 1
 UniProt Protein Name    Echinoderm microtubule-associated protein-like 1
 Protein Family    Echinoderm microtubule-associated protein
 UniProt Gene Name    EML1 [Similar Products]
 UniProt Synonym Gene Names    EMAP1; EMAPL; EMAPL1; EMAP-1; HuEMAP-1 [Similar Products]
 UniProt Entry Name    EMAL1_HUMAN
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 NCBI Summary for EML1    Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EML1    EML1: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Belongs to the WD repeat EMAP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: cytosol; microtubule; microtubule associated complex; perinuclear region of cytoplasm

Molecular Function: calcium ion binding; microtubule binding; protein binding; tubulin binding

Biological Process: brain development; hemopoietic progenitor cell differentiation; microtubule cytoskeleton organization and biogenesis; mitotic spindle organization and biogenesis; neuroblast proliferation
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 Research Articles on EML1    1. We show that the trimerization domain (TD) of EML1 is necessary and sufficient for self-association. The TD is also essential for MT binding; however, this property requires an adjacent basic region.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EML1 antibodyDiseases associated with anti-EML1 antibody
 Reference Product  PubMed Publications
 NUP214 antibody  >6 publications with EML1 and NUP214
 ALK antibody  >5 publications with EML1 and ALK
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >2 publications with EML1 and Congenital Abnormalities
 Vascular Malformations Antibodies  >1 publications with EML1 and Vascular Malformations
 Brain Diseases Antibodies  >1 publications with EML1 and Brain Diseases
 Proteinuria Antibodies  >1 publications with EML1 and Proteinuria
 Disease Models, Animal Antibodies  >1 publications with EML1 and Disease Models, Animal
Organs/Tissues associated with anti-EML1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with EML1 and Lung
 Intestine Antibodies  >1 publications with EML1 and Intestine
 Embryonic Tissue Antibodies  >1 publications with EML1 and Embryonic Tissue
 Muscle Antibodies  >1 publications with EML1 and Muscle
 Eye Antibodies  >1 publications with EML1 and Eye
 Brain Antibodies  >1 publications with EML1 and Brain
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