Q04743.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homeobox protein EMX2
NCBI Official Synonym Full Names
empty spiracles homeobox 2
NCBI Protein Information
homeobox protein EMX2; empty spiracles homolog 2; empty spiracles-like protein 2
UniProt Protein Name
Homeobox protein EMX2
UniProt Synonym Protein Names
Empty spiracles homolog 2; Empty spiracles-like protein 2
UniProt Entry Name
EMX2_HUMAN
NCBI Summary for EMX2
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
UniProt Comments for EMX2
EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 10q26.1
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: response to drug; forebrain cell migration; anterior/posterior pattern formation; neuron differentiation; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalization
Disease: Schizencephaly
Research Articles on EMX2
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Products associated with anti-EMX2 antibody
Diseases associated with anti-EMX2 antibody
Organs/Tissues associated with anti-EMX2 antibody
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