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anti-EMX2 antibody :: Rabbit EMX2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151542
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EMX2, Polyclonal Antibody

★Popular Item★
 Also Known As   

EMX2 Antibody

 Product Synonym Names    EMX2; Homeobox protein EMX2; Empty spiracles homolog 2
 Product Gene Name   

anti-EMX2 antibody

[Similar Products]
 Antibody/Peptide Pairs    EMX2 peptide (MBS152065) is used for blocking the activity of EMX2 antibody (MBS151542)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 600035
 3D Structure    ModBase 3D Structure for Q04743
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human; Predicted Species reactivity based on immunogen sequence: Mouse: (100%), Bovine (100%)
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 Specificity    At least two isoforms of EMX2 are known to exist; this antibody will detect both isoforms. EMX2 antibody is predicted to not cross-react with EMX1
 Purity/Purification    EMX2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    EMX2 antibody was raised against an 18 amino acid synthetic peptide near the center of human EMX2. The immunogen is located within amino acids 60-110 of EMX2.
 Buffer    EMX2 Antibody is supplied in PBS containing 0.02% sodium azide.
 Positive Control    MBS151589: Human Lung Tissue Lysate
MBS154259: Human Lung Tissue Slide
    
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 Preparation and Storage    EMX2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-EMX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EMX2 antibody

   EMX2 Antibody: EMX2, like its closely related homolog EMX1, is a homeobox transcription factor involved in specifying cell fates in the developing central nervous system and participates in the development of olfactory neurons. EMX2 is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10.
 Applications Tested/Suitable for anti-EMX2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC-P), Immunofluorescence (IF)

 Application Notes for anti-EMX2 antibody    EMX2 antibody can be used for detection of EMX2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 ug/mL.

Optimal dilutions for each application to be determined by the researcher.
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 Western Blot (WB) of anti-EMX2 antibody    Western blot analysis of EMX2 in human lung tissue lysate with EMX2 antibody at (A) 1 and (B) 2 μg/mL.
anti-EMX2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-EMX2 antibody    Immunofluorescence of EMX2 in human lung tissue with EMX2 antibody at 20 μg/mL.
anti-EMX2 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-EMX2 antibody    Immunohistochemistry of EMX2 in human lung tissue with EMX2 antibody at 2.5 μg/mL.
anti-EMX2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EMX2. It may not necessarily be applicable to this product.
 NCBI GI #    19862512
 NCBI GeneID    2018
 NCBI Accession #    Q04743.2 [Other Products]
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 UniProt Primary Accession #    Q04743 [Other Products]
 UniProt Secondary Accession #    Q96NN8; Q9BQF4; G3V305 [Other Products]
 UniProt Related Accession #    Q04743 [Other Products]
 Molecular Weight    18,518 Da
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 NCBI Official Full Name    Homeobox protein EMX2
 NCBI Official Synonym Full Names    empty spiracles homeobox 2
 NCBI Official Symbol    EMX2 [Similar Products]
 NCBI Protein Information    homeobox protein EMX2; empty spiracles homolog 2; empty spiracles-like protein 2
 UniProt Protein Name    Homeobox protein EMX2
 UniProt Synonym Protein Names   
Empty spiracles homolog 2; Empty spiracles-like protein 2
 Protein Family    Homeobox protein
 UniProt Gene Name    EMX2 [Similar Products]
 UniProt Entry Name    EMX2_HUMAN
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 NCBI Summary for EMX2    This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
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 UniProt Comments for EMX2    EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 10q26.1

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding

Biological Process: forebrain cell migration; neuron differentiation; response to drug; anterior/posterior pattern formation; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalization

Disease: Schizencephaly
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 Research Articles on EMX2    1. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EMX2 antibodyDiseases associated with anti-EMX2 antibody
 Reference Product  PubMed Publications
 SHH antibody  >10 publications with EMX2 and SHH
 PAX2 antibody  >5 publications with EMX2 and PAX2
 FOXG1 antibody  >5 publications with EMX2 and FOXG1
 TBR1 antibody  >4 publications with EMX2 and TBR1
 EGFR antibody  >3 publications with EMX2 and EGFR
 WNT7B antibody  >2 publications with EMX2 and WNT7B
 GFRA1 antibody  >2 publications with EMX2 and GFRA1
 WNT2B antibody  >1 publications with EMX2 and WNT2B
 WNT3A antibody  >1 publications with EMX2 and WNT3A
 EIF4E antibody  >1 publications with EMX2 and EIF4E
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >26 publications with EMX2 and Nervous System Diseases
 Brain Diseases Antibodies  >13 publications with EMX2 and Brain Diseases
 Familial schizencephaly Antibodies  >11 publications with EMX2 and Familial schizencephaly
 Female Urogenital Diseases Antibodies  >11 publications with EMX2 and Female Urogenital Diseases
 Carcinoma Antibodies  >5 publications with EMX2 and Carcinoma
 Abnormalities, Drug-Induced Antibodies  >3 publications with EMX2 and Abnormalities, Drug-Induced
 Eye Diseases Antibodies  >3 publications with EMX2 and Eye Diseases
 Neurobehavioral Manifestations Antibodies  >3 publications with EMX2 and Neurobehavioral Manifestations
 Adenocarcinoma Antibodies  >3 publications with EMX2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >3 publications with EMX2 and Lung Neoplasms
Organs/Tissues associated with anti-EMX2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >136 publications with EMX2 and Brain
 Embryonic Tissue Antibodies  >35 publications with EMX2 and Embryonic Tissue
 Eye Antibodies  >24 publications with EMX2 and Eye
 Uterus Antibodies  >14 publications with EMX2 and Uterus
 Kidney Antibodies  >10 publications with EMX2 and Kidney
 Ovary Antibodies  >7 publications with EMX2 and Ovary
 Muscle Antibodies  >6 publications with EMX2 and Muscle
 Heart Antibodies  >3 publications with EMX2 and Heart
 Uncharacterized Tissue Antibodies  >1 publications with EMX2 and Uncharacterized Tissue
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