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anti-ENAM antibody :: Rabbit anti-Human ENAM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205809
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ENAM, Polyclonal Antibody

★Popular Item★
 Also Known As   

ENAM Antibody (C-term)

 Product Synonym Names    Enamelin; ENAM
 Product Gene Name   

anti-ENAM antibody

[Similar Products]
 Antibody/Peptide Pairs    ENAM peptide (MBS9225803) is used for blocking the activity of ENAM antibody (MBS9205809)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    1097-1126
 OMIM    104500
 3D Structure    ModBase 3D Structure for Q9NRM1
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB20947
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This ENAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1097-1126 amino acids from the C-terminal region of human ENAM.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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 Function    Involved in the mineralization and structural organization of enamel. Involved un the extension of enamel during the secretory stage of dental enamel formation.
 Cellular Location    Secreted, extracellular space, extracellular matrix {ECO:0000250|UnitProtKB:O97939}
 Tissue Location    Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
    
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ENAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ENAM antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC-P), Flow Cytometry (FC/FACS)

 Application Notes for anti-ENAM antibody    WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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 Western Blot (WB) of anti-ENAM antibody    ENAM Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ENAM antibody detected the ENAM protein (arrow).
anti-ENAM antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ENAM antibody    ENAM antibody(C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ENAM antibody(C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ENAM antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-ENAM antibody    ENAM Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ENAM antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for ENAM. It may not necessarily be applicable to this product.
 NCBI GI #    189491628
 NCBI GeneID    10117
 NCBI Accession #    NP_114095.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_031889.2 [Other Products]
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 UniProt Primary Accession #    Q9NRM1 [Other Products]
 UniProt Secondary Accession #    Q17RI5; Q9H3D1 [Other Products]
 UniProt Related Accession #    Q9NRM1 [Other Products]
 Molecular Weight    128785
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 NCBI Official Full Name    enamelin
 NCBI Official Synonym Full Names    enamelin
 NCBI Official Symbol    ENAM [Similar Products]
 NCBI Official Synonym Symbols   
ADAI; AI1C; AIH2
[Similar Products]
 NCBI Protein Information    enamelin
 UniProt Protein Name    Enamelin
 Protein Family    Enamelin
 UniProt Gene Name    ENAM [Similar Products]
 UniProt Entry Name    ENAM_HUMAN
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 NCBI Summary for ENAM    Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]
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 UniProt Comments for ENAM    enamelin: Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. Defects in ENAM are the cause of amelogenesis imperfecta type 1B (AI1B). AI1B is an autosomal dominant defect of enamel formation. Clinical manifestations may be variable. Some cases present with generalized enamel hypoplasia resulting in small, smooth, yellow and spaced teeth (smooth hypoplastic AI). Others show horizontal rows of pits, grooves or a hypoplastic area in the enamel (local hypoplastic AI). Defects in ENAM are the cause of amelogenesis imperfecta type 1C (AI1C); also known as amelogenesis imperfecta hypoplastic with or without openbite malocclusion. AI1C is an autosomal recessive defect of dental enamel formation. Teeth show hypoplastic and unmineralized enamel, and a yellow-brown discoloration. Enamel defects can be associated with facial and oral features including vertical dysgnathia and anterior openbite malocclusion.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: proteinaceous extracellular matrix

Biological Process: biomineral formation

Disease: Amelogenesis Imperfecta, Type Ic; Amelogenesis Imperfecta, Type Ib
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 Research Articles on ENAM    1. Whole-exome sequencing identified 2 novel heterozygous nonsense mutations in the ENAM gene (c.454G>T p.Glu152* in family 1, c.358C>T p.Gln120* in family 2) in the probands. Affected individuals were heterozygous for the mutation in each family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ENAM antibodyDiseases associated with anti-ENAM antibody
 Reference Product  PubMed Publications
 AMBN antibody  >40 publications with ENAM and AMBN
 AMELX antibody  >35 publications with ENAM and AMELX
 MMP20 antibody  >24 publications with ENAM and MMP20
 KLK4 antibody  >21 publications with ENAM and KLK4
 AMTN antibody  >6 publications with ENAM and AMTN
 TUFT1 antibody  >5 publications with ENAM and TUFT1
 Disease Name  Pubmed Publications
 Amelogenesis Imperfecta Antibodies  >51 publications with ENAM and Amelogenesis Imperfecta
 Brain Diseases Antibodies  >33 publications with ENAM and Brain Diseases
 Hypertension Antibodies  >5 publications with ENAM and Hypertension
 Neoplasms, Experimental Antibodies  >4 publications with ENAM and Neoplasms, Experimental
 Edema Antibodies  >4 publications with ENAM and Edema
 Lymphatic Diseases Antibodies  >3 publications with ENAM and Lymphatic Diseases
 Alzheimer Disease Antibodies  >3 publications with ENAM and Alzheimer Disease
 Lymphoma Antibodies  >3 publications with ENAM and Lymphoma
 Nervous System Malformations Antibodies  >3 publications with ENAM and Nervous System Malformations
 Death Antibodies  >2 publications with ENAM and Death
Organs/Tissues associated with anti-ENAM antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >8 publications with ENAM and Embryonic Tissue
 Eye Antibodies  >5 publications with ENAM and Eye
 Kidney Antibodies  >1 publications with ENAM and Kidney
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