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anti-ENOX2 antibody :: Goat ENOX2/APK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421550 anti-ENOX2 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ENOX2/APK1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-ENOX2/APK1 Antibody

 Product Synonym Names    ecto-NOX disulfide-thiol exchanger 2; RP5-875H3.1; APK1; COVA1; tNOX; APK1 antigen; cytosolic ovarian carcinoma antigen 1; ecto-NOX disulfide-thiol exchanger 2 antibody; RP5-875H3.1 antibody; APK1 antibody; COVA1 antibody; tNOX antibody; APK1 antigen antibody; cytosolic ovarian carcinoma antigen 1 antibody; ENOX2 / APK1
 Product Gene Name   

anti-ENOX2 antibody

[Similar Products]
 Product Synonym Gene Name    APK1 [Similar Products]
 Antibody/Peptide Pairs    ENOX2 / APK1 peptide (MBS425835) is used for blocking the activity of ENOX2/APK1 antibody (MBS421550)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EKLKDDKLQV EK
 OMIM    300282
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-EKLKDDKLQVEK, from the internal region of the protein sequence according to NP_006366.2; NP_872114.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_006366.2; NP_872114.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ENOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ENOX2 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-ENOX2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave bands at approx 60kDa and 37kDa in Human Heart lysates after 0. 03ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 66.6kDa and 70.1kDa according to NP_006366.2 and NP_872114.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
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NCBI/Uniprot data below describe general gene information for ENOX2. It may not necessarily be applicable to this product.
 NCBI GI #    32528293
 NCBI GeneID    10495
 NCBI Accession #    NP_006366.2 [Other Products]
 NCBI Related Accession #    NP_872114.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006375.3 [Other Products]
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 UniProt Secondary Accession #    Q5VTJ1; Q5VTJ2; Q8WUX0; Q9NTP6; Q9UH82; A8K197; A8K1C2 [Other Products]
 UniProt Related Accession #    Q16206 [Other Products]
 Molecular Weight    66,621 Da
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 NCBI Official Full Name    ecto-NOX disulfide-thiol exchanger 2 isoform a
 NCBI Official Synonym Full Names    ecto-NOX disulfide-thiol exchanger 2
 NCBI Official Symbol    ENOX2 [Similar Products]
 NCBI Official Synonym Symbols   
APK1; tNOX; COVA1
[Similar Products]
 NCBI Protein Information    ecto-NOX disulfide-thiol exchanger 2
 UniProt Protein Name    Ecto-NOX disulfide-thiol exchanger 2
 UniProt Synonym Protein Names   
APK1 antigen; Cytosolic ovarian carcinoma antigen 1; Tumor-associated hydroquinone oxidase; tNOX
 Protein Family    Ecto-NOX disulfide-thiol exchanger
 UniProt Gene Name    ENOX2 [Similar Products]
 UniProt Synonym Gene Names    COVA1; tNOX [Similar Products]
 UniProt Entry Name    ENOX2_HUMAN
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 NCBI Summary for ENOX2    This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for ENOX2    ENOX2: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Belongs to the ENOX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Cell surface; EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: cytosol; external side of plasma membrane; extracellular space

Molecular Function: nucleic acid binding; nucleotide binding; protein binding; protein disulfide oxidoreductase activity

Biological Process: cell growth; regulation of growth; ultradian rhythm
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 Research Articles on ENOX2    1. The findings support a role for arNOX as a major source of oxidative damage leading to cross-linking of skin proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ENOX2 antibodyOrgans/Tissues associated with anti-ENOX2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with ENOX2 and Carcinoma
 Uterine Cervical Neoplasms Antibodies  >3 publications with ENOX2 and Uterine Cervical Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with ENOX2 and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >1 publications with ENOX2 and Lung Neoplasms
 Fibrosis Antibodies  >1 publications with ENOX2 and Fibrosis
 Breast Neoplasms Antibodies  >1 publications with ENOX2 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with ENOX2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with ENOX2 and Lung
 Stomach Antibodies  >2 publications with ENOX2 and Stomach
 Liver Antibodies  >2 publications with ENOX2 and Liver
 Heart Antibodies  >1 publications with ENOX2 and Heart
 Kidney Antibodies  >1 publications with ENOX2 and Kidney
 Connective Tissue Antibodies  >1 publications with ENOX2 and Connective Tissue
 Prostate Antibodies  >1 publications with ENOX2 and Prostate
 Embryonic Tissue Antibodies  >1 publications with ENOX2 and Embryonic Tissue
 Skin Antibodies  >1 publications with ENOX2 and Skin
 Intestine Antibodies  >1 publications with ENOX2 and Intestine
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