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anti-PTGER1 antibody :: Goat EP1 receptor/PTGER1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420141
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EP1 receptor/PTGER1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-EP1 receptor/PTGER1 Antibody

 Product Synonym Names    PTGER1; prostaglandin E receptor 1 (subtype EP1), 42kDa; EP1; PGE receptor, EP1 subtype; prostaglandin E receptor 1, subtype EP1; prostanoid EP1 receptor; PTGER1 antibody; prostaglandin E receptor 1 (subtype EP1); 42kDa antibody; EP1 antibody; PGE receptor; EP1 subtype antibody; prostaglandin E receptor 1; subtype EP1 antibody; prostanoid EP1 receptor antibody; EP1 receptor / PTGER1
 Product Gene Name   

anti-PTGER1 antibody

[Similar Products]
 Product Synonym Gene Name    EP1 [Similar Products]
 Antibody/Peptide Pairs    EP1 receptor / PTGER1 peptide (MBS426736) is used for blocking the activity of EP1 receptor/PTGER1 antibody (MBS420141)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DSRRRWGAHG PRS
 OMIM    176802
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DSRRRWGAHGPRS, from the internal region of the protein sequence according to NP_000946.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PTGER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PTGER1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-PTGER1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Kidney shows membranous staining in the epithelial cells of DCT. Recommended concentration, 1-2ug/ml.
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 Immunohistochemistry (IHC) of anti-PTGER1 antibody    (2ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
anti-PTGER1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PTGER1. It may not necessarily be applicable to this product.
 NCBI GI #    38505194
 NCBI GeneID    5731
 NCBI Accession #    NP_000946.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000955.2 [Other Products]
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 UniProt Secondary Accession #    Q5U5U4; Q86UH3; Q86VB5; Q8NHB2 [Other Products]
 UniProt Related Accession #    P34995 [Other Products]
 Molecular Weight    41,801 Da
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 NCBI Official Full Name    prostaglandin E2 receptor EP1 subtype
 NCBI Official Synonym Full Names    prostaglandin E receptor 1
 NCBI Official Symbol    PTGER1 [Similar Products]
 NCBI Official Synonym Symbols   
EP1
[Similar Products]
 NCBI Protein Information    prostaglandin E2 receptor EP1 subtype
 UniProt Protein Name    Prostaglandin E2 receptor EP1 subtype
 UniProt Synonym Protein Names   
Prostanoid EP1 receptor
 Protein Family    Prostaglandin E2 receptor
 UniProt Gene Name    PTGER1 [Similar Products]
 UniProt Synonym Gene Names    PGE receptor EP1 subtype; PGE2 receptor EP1 subtype [Similar Products]
 UniProt Entry Name    PE2R1_HUMAN
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 NCBI Summary for PTGER1    The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PTGER1    PTGER1: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide
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 Research Articles on PTGER1    1. A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PTGER1 antibodyDiseases associated with anti-PTGER1 antibody
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >31 publications with PTGER1 and Inflammation
 Disease Models, Animal Antibodies  >28 publications with PTGER1 and Disease Models, Animal
 Carcinoma Antibodies  >20 publications with PTGER1 and Carcinoma
 Hyperalgesia Antibodies  >12 publications with PTGER1 and Hyperalgesia
 Hypertension Antibodies  >11 publications with PTGER1 and Hypertension
 Adenocarcinoma Antibodies  >11 publications with PTGER1 and Adenocarcinoma
 Necrosis Antibodies  >9 publications with PTGER1 and Necrosis
 Kidney Diseases Antibodies  >7 publications with PTGER1 and Kidney Diseases
 Breast Neoplasms Antibodies  >6 publications with PTGER1 and Breast Neoplasms
 Skin Neoplasms Antibodies  >6 publications with PTGER1 and Skin Neoplasms
Organs/Tissues associated with anti-PTGER1 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >40 publications with PTGER1 and Kidney
 Brain Antibodies  >39 publications with PTGER1 and Brain
 Embryonic Tissue Antibodies  >11 publications with PTGER1 and Embryonic Tissue
 Ovary Antibodies  >10 publications with PTGER1 and Ovary
 Eye Antibodies  >8 publications with PTGER1 and Eye
 Pancreas Antibodies  >2 publications with PTGER1 and Pancreas
 Thymus Antibodies  >1 publications with PTGER1 and Thymus
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