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anti-EP300 antibody :: Rabbit anti-Human EP300 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2525701 anti-EP300 antibody
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EP300, Polyclonal Antibody

 Also Known As   

EP300 Antibody

 Product Synonym Names    KAT3B; p300
 Product Gene Name   

anti-EP300 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602700
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Peptide of EP300
 Calculated Molecular Weight: 264kd   
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-585 / sc-8981 / sc-584
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EP300 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EP300 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for EP300. It may not necessarily be applicable to this product.
 NCBI GI #    31753089
 NCBI GeneID    2033
 NCBI Accession #    AAH53889.1 [Other Products]
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 UniProt Secondary Accession #    B1AKC2 [Other Products]
 UniProt Related Accession #    Q09472 [Other Products]
 Molecular Weight    264,161 Da
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 NCBI Official Full Name    EP300 protein, partial
 NCBI Official Synonym Full Names    E1A binding protein p300
 NCBI Official Symbol    EP300 [Similar Products]
 NCBI Official Synonym Symbols   
p300; KAT3B; RSTS2
[Similar Products]
 NCBI Protein Information    histone acetyltransferase p300; E1A-associated protein p300; E1A-binding protein, 300kD; p300 HAT
 UniProt Protein Name    Histone acetyltransferase p300
 UniProt Synonym Protein Names   
E1A-associated protein p300
 Protein Family    EP300-interacting inhibitor of differentiation
 UniProt Gene Name    EP300 [Similar Products]
 UniProt Synonym Gene Names    P300; p300 HAT [Similar Products]
 UniProt Entry Name    EP300_HUMAN
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 NCBI Summary for EP300    This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EP300    p300: a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2.

Protein type: EC 2.3.1.48; Transcription, coactivator/corepressor; Acetyltransferase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; histone acetyltransferase complex

Molecular Function: lysine N-acetyltransferase activity; transcription activator binding; zinc ion binding; chromatin DNA binding; p53 binding; transcription coactivator activity; beta-catenin binding; transcription factor binding; protein binding; histone acetyltransferase activity; DNA binding; androgen receptor binding; acetyltransferase activity; transferase activity, transferring acyl groups; chromatin binding; nuclear hormone receptor binding

Biological Process: circadian rhythm; establishment and/or maintenance of chromatin architecture; viral reproduction; positive regulation of protein binding; apoptosis; regulation of cell cycle; heart development; positive regulation of transcription of target genes involved in unfolded protein response; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; positive regulation of interferon type I production; G2/M transition of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; nervous system development; Notch signaling pathway; somitogenesis; skeletal muscle development; internal peptidyl-lysine acetylation; transcription, DNA-dependent; protein stabilization; organ morphogenesis; protein amino acid acetylation; response to estrogen stimulus; response to hypoxia; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; mitotic cell cycle; internal protein amino acid acetylation; N-terminal peptidyl-lysine acetylation; lung development

Disease: Rubinstein-taybi Syndrome 2; Rubinstein-taybi Syndrome 1; Colorectal Cancer
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 Research Articles on EP300    1. the presence of p300 in the cytoplasm correlates with increased survival of breast cancer patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EP300 antibodyPathways associated with anti-EP300 antibody
 Reference Product  PubMed Publications
 RELA antibody  >29 publications with EP300 and RELA
 HIF1A antibody  >28 publications with EP300 and HIF1A
 TP53 antibody  >24 publications with EP300 and TP53
 SP1 antibody  >21 publications with EP300 and SP1
 CARM1 antibody  >12 publications with EP300 and CARM1
 CITED2 antibody  >10 publications with EP300 and CITED2
 CREB1 antibody  >9 publications with EP300 and CREB1
 NCOA3 antibody  >6 publications with EP300 and NCOA3
 MYOD1 antibody  >2 publications with EP300 and MYOD1
 ESR1 antibody  >1 publications with EP300 and ESR1
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-EP300 antibodyOrgans/Tissues associated with anti-EP300 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >33 publications with EP300 and Necrosis
 Rubinstein-Taybi Syndrome Antibodies  >33 publications with EP300 and Rubinstein-Taybi Syndrome
 Breast Neoplasms Antibodies  >32 publications with EP300 and Breast Neoplasms
 Inflammation Antibodies  >30 publications with EP300 and Inflammation
 Cardiovascular Diseases Antibodies  >22 publications with EP300 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >21 publications with EP300 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >21 publications with EP300 and Neoplasms, Experimental
 Hypertrophy Antibodies  >19 publications with EP300 and Hypertrophy
 Colorectal Neoplasms Antibodies  >19 publications with EP300 and Colorectal Neoplasms
 Liver Diseases Antibodies  >18 publications with EP300 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >84 publications with EP300 and Blood
 Muscle Antibodies  >78 publications with EP300 and Muscle
 Heart Antibodies  >47 publications with EP300 and Heart
 Bone Antibodies  >42 publications with EP300 and Bone
 Liver Antibodies  >40 publications with EP300 and Liver
 Brain Antibodies  >31 publications with EP300 and Brain
 Lung Antibodies  >29 publications with EP300 and Lung
 Nerve Antibodies  >27 publications with EP300 and Nerve
 Kidney Antibodies  >26 publications with EP300 and Kidney
 Embryonic Tissue Antibodies  >23 publications with EP300 and Embryonic Tissue
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