NP_004429.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
104,507 Da
NCBI Official Full Name
ephrin type-A receptor 4 isoform a
NCBI Official Synonym Full Names
EPH receptor A4
NCBI Protein Information
ephrin type-A receptor 4; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; receptor protein-tyrosine kinase HEK8; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK
UniProt Protein Name
Ephrin type-A receptor 4
UniProt Synonym Protein Names
EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
UniProt Synonym Gene Names
UniProt Entry Name
EPHA4_HUMAN
NCBI Summary for EPHA4
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
UniProt Comments for EPHA4
EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; EC 2.7.10.1; TK group; Eph family
Chromosomal Location of Human Ortholog: 2q36.1
Cellular Component: Golgi apparatus; cell surface; integral to plasma membrane; endoplasmic reticulum; postsynaptic density; dendrite; dendritic spine; perikaryon; postsynaptic membrane; mitochondrial outer membrane; early endosome membrane; axon; cytoplasm; plasma membrane; nerve terminal; cell junction; neuromuscular junction; filopodium
Molecular Function: identical protein binding; protein binding; transmembrane-ephrin receptor activity; ephrin receptor binding; GPI-linked ephrin receptor activity; PH domain binding; ATP binding; protein kinase activity
Biological Process: axon guidance; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; protein amino acid autophosphorylation; ephrin receptor signaling pathway; motor axon guidance; regulation of astrocyte differentiation; positive regulation of dendrite morphogenesis; glial cell migration; cell adhesion; corticospinal tract morphogenesis; regulation of axonogenesis; adult walking behavior
Research Articles on EPHA4
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Products associated with anti-EPHA4 antibody
Pathways associated with anti-EPHA4 antibody
Diseases associated with anti-EPHA4 antibody
Organs/Tissues associated with anti-EPHA4 antibody
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