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anti-EPHB4 antibody :: Rabbit anti-Human, Mouse EPHB4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9604677
Western Blot (WB)
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPHB4, Polyclonal Antibody

★Popular Item★
 Also Known As   

EPHB4 Antibody

 Product Synonym Names    Ephb4; EPHB4_HUMAN; Ephrin receptor EphB4; Ephrin type-B receptor 4; Hepatoma Transmembrane Kinase; HTK; MYK 1; MYK1; TYRO 11; TYRO11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11
 Product Gene Name   

anti-EPHB4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P54760
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    EPHB4 antibody detects endogenous levels of total EPHB4
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide
 Subcellular Location    Membrane.
 Tissue Specificity    Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-EPHB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EPHB4 antibody

   Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Subunit Structure: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
Post-translational Modifications: Phosphorylated; autophosphorylation is stimulated by EFNB2.
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
 Applications Tested/Suitable for anti-EPHB4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-EPHB4 antibody    WB: 1:500-1:1000
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 Western Blot (WB) of anti-EPHB4 antibody    Western blot analysis of extracts from 293 cells using EPHB4 antibody.
anti-EPHB4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for EPHB4. It may not necessarily be applicable to this product.
 NCBI GI #    32528301
 NCBI GeneID    2050
 NCBI Accession #    NP_004435.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004444.4 [Other Products]
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 UniProt Primary Accession #    P54760 [Other Products]
 UniProt Secondary Accession #    Q7Z635; Q9BTA5; Q9BXP0; B5A970; B5A971; B5A972 [Other Products]
 UniProt Related Accession #    P54760 [Other Products]
 Molecular Weight    Observed: 108 kD
Predicted: 109 kDa
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 NCBI Official Full Name    ephrin type-B receptor 4
 NCBI Official Synonym Full Names    EPH receptor B4
 NCBI Official Symbol    EPHB4 [Similar Products]
 NCBI Official Synonym Symbols   
HTK; MYK1; HFASD; TYRO11
[Similar Products]
 NCBI Protein Information    ephrin type-B receptor 4
 UniProt Protein Name    Ephrin type-B receptor 4
 UniProt Synonym Protein Names   
Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11
 Protein Family    Ephrin type-B receptor
 UniProt Gene Name    EPHB4 [Similar Products]
 UniProt Synonym Gene Names    HTK; MYK1; TYRO11 [Similar Products]
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 NCBI Summary for EPHB4    Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EPHB4    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
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 Research Articles on EPHB4    1. functional expression of EphB4 is considered a promising differentiating characteristic, preferentially determined by non-invasive in vivo imaging, which may improve personalized theranostics of malignant melanoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPHB4 antibodyPathways associated with anti-EPHB4 antibody
 Reference Product  PubMed Publications
 EFNB2 antibody  >15 publications with EPHB4 and EFNB2
 SDC3 antibody  >1 publications with EPHB4 and SDC3
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram
 EphrinB-EPHB Pathway antibodies  EphrinB-EPHB Pathway Diagram
Diseases associated with anti-EPHB4 antibodyOrgans/Tissues associated with anti-EPHB4 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >122 publications with EPHB4 and Neoplasms
 Breast Neoplasms Antibodies  >18 publications with EPHB4 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >17 publications with EPHB4 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >16 publications with EPHB4 and Lung Neoplasms
 Lung Diseases Antibodies  >15 publications with EPHB4 and Lung Diseases
 Adenocarcinoma Antibodies  >12 publications with EPHB4 and Adenocarcinoma
 Brain Diseases Antibodies  >11 publications with EPHB4 and Brain Diseases
 Inflammation Antibodies  >10 publications with EPHB4 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >7 publications with EPHB4 and Carcinoma, Hepatocellular
 Uterine Neoplasms Antibodies  >7 publications with EPHB4 and Uterine Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >141 publications with EPHB4 and Vascular
 Embryonic Tissue Antibodies  >50 publications with EPHB4 and Embryonic Tissue
 Bone Antibodies  >37 publications with EPHB4 and Bone
 Brain Antibodies  >35 publications with EPHB4 and Brain
 Lung Antibodies  >31 publications with EPHB4 and Lung
 Eye Antibodies  >24 publications with EPHB4 and Eye
 Muscle Antibodies  >23 publications with EPHB4 and Muscle
 Heart Antibodies  >20 publications with EPHB4 and Heart
 Nerve Antibodies  >12 publications with EPHB4 and Nerve
 Liver Antibodies  >12 publications with EPHB4 and Liver
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