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anti-EPM2A antibody :: Rabbit anti-Human EPM2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7046162
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPM2A, Polyclonal Antibody

★Popular Item★
 Also Known As   

EPM2A Antibody

 Product Synonym Names    Laforin; isoform 91 Publication; EPM2A1
 Product Gene Name   

anti-EPM2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for B3EWF7
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Laforin, isoform 9 protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EPM2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EPM2A antibody

   negative regulation of TOR signaling, positive regulation of macroautophagy
 Applications Tested/Suitable for anti-EPM2A antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-EPM2A antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7046162 at dilution 1:100
anti-EPM2A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-EPM2A antibody    Immunofluorescent analysis of Hela cells using MBS7046162 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-EPM2A antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-EPM2A antibody    Western Blot
Positive WB detected in:Mouse skeletal muscle tissue
All lanes: EPM2A antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36 kDa
Observed band size: 36 kDa

anti-EPM2A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for EPM2A. It may not necessarily be applicable to this product.
 NCBI GI #    380876884
 NCBI GeneID    7957
 NCBI Accession #    B3EWF7.1 [Other Products]
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 UniProt Primary Accession #    B3EWF7 [Other Products]
 UniProt Related Accession #    O95278; B3EWF7 [Other Products]
 Molecular Weight    20,256 Da
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 NCBI Official Full Name    Laforin, isoform 9
 NCBI Official Synonym Full Names    epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
 NCBI Official Symbol    EPM2A [Similar Products]
 NCBI Official Synonym Symbols   
EPM2; MELF
[Similar Products]
 NCBI Protein Information    laforin
 UniProt Protein Name    Laforin, isoform 9
 Protein Family    EPM2A-interacting protein
 UniProt Gene Name    EPM2A [Similar Products]
 UniProt Entry Name    EP2A2_HUMAN
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 NCBI Summary for EPM2A    This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EPM2A    laforin iso9: Dual specificity protein phosphatase. May be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1. Defects in EPM2A are a cause of progressive myoclonic epilepsy type 2 (EPM2); also known as Lafora disease. EPM2 is an autosomal recessive and severe form of adolescent-onset progressive epilepsy. Typically, as seizures increase in frequency, cognitive function declines towards dementia, and affected individuals die usually within 10 years after onset. EPM2 occurs worldwide, but it is particularly common in the mediterranean countries of southern Europe and northern Africa, in southern India and in the Middle East. At the cellular level, it is characterized by accumulation of starch-like polyglucosans called Lafora bodies (LBs) that are most abundant in organs with the highest glucose metabolism: brain, heart, liver and skeletal muscle. Among other conditions involving polyglucosans, EPM2 is unique in that the inclusions are in neuronal dendrites but not axons and the forming polyglucosan fibrils are associated with the endoplasmic reticulum. Belongs to the protein-tyrosine phosphatase family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 6q24

Biological Process: negative regulation of TOR signaling pathway; positive regulation of macroautophagy
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 Research Articles on EPM2A    1. Laforin-glycan interactions occur with a favourable enthalpic contribution counter-balanced by an unfavourable entropic contribution.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-EPM2A antibodyOrgans/Tissues associated with anti-EPM2A antibody
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Carbohydrate Metabolism Pathway antibodies  Diseases Of Carbohydrate Metabolism Pathway Diagram
 Diseases Of Metabolism Pathway antibodies  Diseases Of Metabolism Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycogen Synthesis Pathway antibodies  Glycogen Synthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Myoclonic Epilepsy Of Lafora Pathway antibodies  Myoclonic Epilepsy Of Lafora Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >170 publications with EPM2A and Brain
 Muscle Antibodies  >80 publications with EPM2A and Muscle
 Skin Antibodies  >79 publications with EPM2A and Skin
 Liver Antibodies  >51 publications with EPM2A and Liver
 Heart Antibodies  >28 publications with EPM2A and Heart
 Eye Antibodies  >9 publications with EPM2A and Eye
 Kidney Antibodies  >4 publications with EPM2A and Kidney
 Thyroid Antibodies  >3 publications with EPM2A and Thyroid
 Vascular Antibodies  >2 publications with EPM2A and Vascular
 Prostate Antibodies  >1 publications with EPM2A and Prostate
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