Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource rightarrow Antibody rightarrow EPS8 rightarrow Polyclonal EPS8  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
Our Best Sellers moreseparator
 • Calmodulin (CALM2) Antibody
 • VAMP 1,2 (VAMP1) Antibody
 • GIPC1-NIP Antibody
 • Amanitin ELISA Kit
 • 1, 25-dihydroxyvitamin D3 (DVD-DHVD3) ELISA Kit
 • CEBP alpha (CEBPA) Antibody
 • Lactate Dehydrogenase 5 Protein
 • CD140b Antibody
 • Lipase, Hormone Sensitive (LIPE) ELISA Kit
 • Bovine Immunoglobulin Antibody
 • Gram + bacteria Antibody
 • cornichon homolog 3 (CNIH3) Antibody
 • Aspartate Aminotransferase (AST) ELISA Kit
 • ACOX1 Antibody
 downarrow more ...
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-EPS8 antibody :: Rabbit EPS8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2523843
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPS8, Polyclonal Antibody

★Popular Item★
 Also Known As   

EPS8 Antibody

 Product Gene Name   

anti-EPS8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    600206
 3D Structure    ModBase 3D Structure for Q12929
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen affinity purification
Section Bar
 Immunogen    Fusion protein of EPS8
 Calculated Molecular Weight    822aa; 92kd
 Observed Molecular Weight    97kd
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30778 / sc-30776 / sc-30777 / sc-30778 / sc-30776 / sc-30777 / sc-1841
Section Bar
 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EPS8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar

Related Product Information for anti-EPS8 antibody

   Epidermal growth factor receptor Pathway Substrate 8 (EPS8) is a crucial regulator of the actin cytoskeleton dynamics accompanying cell motility and invasion. This protein contains one PH domain and one SH3 domain leading to its binding activity with multiple cellular targets. EPS8 can function as a unique actin capping protein specifically required for dendritic cell migration and plays roles in the regulation of axonal filopodia in neuronal development and synapse formation. The EPS8 gene may contribute to the development of a subset of colorectal cancers and could have applications in diagnosis and treatment.
 Applications Tested/Suitable for anti-EPS8 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-EPS8 antibody    WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
Section Bar
 SDS-PAGE of anti-EPS8 antibody    human brain tissue were subjected to SDS-PAGE followed by western blot with EPS8 Polyclonal Antibody at dilution of 1:500
anti-EPS8 antibody SDS-PAGE image
Section Bar
 Immunofluorescent of anti-EPS8 antibody    Immunofluorescent analysis of A375 ells using EPS8 Antibody at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti- Rabbit IgG(H+L)
anti-EPS8 antibody Immunofluorescent image
Section Bar
  Immunohistochemistry of anti-EPS8 antibody    Immunohistochemistry of paraffinembedded human breast cancer tissue slide using EPS8 Polyclonal Antibody at dilution of 1:100 (under 40x lens).
anti-EPS8 antibody  Immunohistochemistry (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for EPS8. It may not necessarily be applicable to this product.
 NCBI GI #    56682953
 NCBI GeneID    2059
 NCBI Accession #    NP_004438.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004447.5 [Other Products]
Section Bar
 UniProt Primary Accession #    Q12929 [Other Products]
 UniProt Secondary Accession #    Q8N6J0; A6NMC3; A8K6W2; A8KA66; B4DX66 [Other Products]
 UniProt Related Accession #    Q12929 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    epidermal growth factor receptor kinase substrate 8
 NCBI Official Synonym Full Names    epidermal growth factor receptor pathway substrate 8
 NCBI Official Symbol    EPS8 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    epidermal growth factor receptor kinase substrate 8
 UniProt Protein Name    Epidermal growth factor receptor kinase substrate 8
 Protein Family    Epidermal growth factor receptor kinase substrate
 UniProt Gene Name    EPS8 [Similar Products]
 UniProt Entry Name    EPS8_HUMAN
Section Bar
 NCBI Summary for EPS8    This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for EPS8    EPS8: an adaptor protein that is an epidermal growth factor receptor (EGFR) substrate. Enhances EGF-dependent mitogenic signals. Member of a family of actin barbing and capping proteins. Promotes filopodial protrusions. Complexes containing Eps8/Abi1/PI3K/Sos-1 mediate Rac activation following EGFR signaling. Involved in endocytosis of EGFR by binding to the Rab5-specific GTPase activating protein USP6N. Binds to IRSp53, which binds small the small GTPases Rac and Cdc42, and which regulates actin dynamics. Involved in the actin-remodeling activity in cultured cerebellar neurons. Regulates the actin-remodeling activities of NMDA and ethanol in neurons. Eps8 knockout mice show behavioral resistance to ethanol. Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: stereocilium; growth cone; postsynaptic density; cell cortex; cell junction; vesicle; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; SH3/SH2 adaptor activity; Rac GTPase binding; actin binding

Biological Process: actin crosslink formation; epidermal growth factor receptor signaling pathway; actin filament bundle formation; positive regulation of signal transduction; adult locomotory behavior; Rac protein signal transduction; behavioral response to ethanol; signal transduction; regulation of cell shape; cell proliferation; actin cytoskeleton reorganization; regulation of actin filament length; barbed-end actin filament capping; exit from mitosis

Disease: Deafness, Autosomal Recessive 102
Table BarTOPTable Bar
 Research Articles on EPS8    1. determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-EPS8 antibodyPathways associated with anti-EPS8 antibody
 Reference Product  PubMed Publications
 SRC antibody  >42 publications with EPS8 and SRC
 ABI1 antibody  >25 publications with EPS8 and ABI1
 EGFR antibody  >19 publications with EPS8 and EGFR
 SOS1 antibody  >17 publications with EPS8 and SOS1
 CDC42 antibody  >11 publications with EPS8 and CDC42
 RAC1 antibody  >9 publications with EPS8 and RAC1
 BAIAP2 antibody  >9 publications with EPS8 and BAIAP2
 USP6NL antibody  >4 publications with EPS8 and USP6NL
 SHB antibody  >2 publications with EPS8 and SHB
 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
Diseases associated with anti-EPS8 antibodyOrgans/Tissues associated with anti-EPS8 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with EPS8 and Nervous System Diseases
 Breast Neoplasms Antibodies  >7 publications with EPS8 and Breast Neoplasms
 Disease Models, Animal Antibodies  >6 publications with EPS8 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >6 publications with EPS8 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >5 publications with EPS8 and Neoplasm Metastasis
 Brain Diseases Antibodies  >5 publications with EPS8 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >5 publications with EPS8 and Carcinoma, Squamous Cell
 Adenoma Antibodies  >4 publications with EPS8 and Adenoma
 Neoplasms, Experimental Antibodies  >4 publications with EPS8 and Neoplasms, Experimental
 Neoplasm Invasiveness Antibodies  >4 publications with EPS8 and Neoplasm Invasiveness
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with EPS8 and Brain
 Blood Antibodies  >19 publications with EPS8 and Blood
 Testis Antibodies  >16 publications with EPS8 and Testis
 Vascular Antibodies  >4 publications with EPS8 and Vascular
 Embryonic Tissue Antibodies  >4 publications with EPS8 and Embryonic Tissue
 Muscle Antibodies  >4 publications with EPS8 and Muscle
 Liver Antibodies  >4 publications with EPS8 and Liver
 Intestine Antibodies  >3 publications with EPS8 and Intestine
 Lung Antibodies  >3 publications with EPS8 and Lung
 Mouth Antibodies  >2 publications with EPS8 and Mouth
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions