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anti-ERBB2 antibody :: Goat ERBB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS448101 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
0.6 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERBB2, Polyclonal Antibody

★Popular Item★
 Also Known As   

ERBB2 Polyclonal Antibody

 Product Synonym Names    Anti-ERBB2; CD340; erb-b2 receptor tyrosine kinase 2; HER2; HER-2; HER-2/neu; MLN 19; NEU; NGL; TKR1 antibody
 Product Gene Name   

anti-ERBB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137215
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Human, Mouse, Rat, Bovine, Canine, Chicken, Avian, Donkey, Feline, Goat, Guinea Pig, Hamster, Horse, Porcine, Rabbit, Sheep, Simian
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 Specificity    Detects endogenous levels of ERBB2 by Western blot.
 Purity/Purification    Epitope Affinity Purified
 Form/Format    Polyclonal antibody supplied as a 200 ul (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
 Concentration    3 mg/ml (lot specific)
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 Immunogen    Recombinant peptide derived from within residues 1,177 aa to the C-terminus of human ERBB2 produced in E Coli.
 Conjugation    Unconjugated
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 Preparation and Storage    Long-term storage: Store at -20 degree C.
Short term storage: Store at 2-8 degree C for up to one month.
 Other Notes    Small volumes of anti-ERBB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ERBB2 antibody

   Goat polyclonal antibody to ERBB2. This protein ia a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases containing a single transmembrane domain and has an approximate molecular weight of 185 kD. ERBB2 contains no ligand binding domain and interacts with other EGF receptor family members to form a heterodimer, stabilize ligand binding, and enhance kinase-mediated downstream signaling. It  has been shown to be involved in embryonic development and cancer progression.
 Applications Tested/Suitable for anti-ERBB2 antibody   

Western Blot (WB)

 Application Notes for anti-ERBB2 antibody    Western blot: 1:500-1:5,000
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 Reactivity Data of anti-ERBB2 antibody    anti-ERBB2 antibody Reactivity Data image
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 Testing Data of anti-ERBB2 antibody    anti-ERBB2 antibody Testing Data image
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 Testing Data of anti-ERBB2 antibody    anti-ERBB2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ERBB2. It may not necessarily be applicable to this product.
 NCBI GI #    6857751
 NCBI GeneID    2064
 NCBI Accession #    AAF30295.1 [Other Products]
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 UniProt Secondary Accession #    Q14256; Q6LDV1; Q9UMK4; B2RZG3; B4DHN3; X5D2V5 [Other Products]
 UniProt Related Accession #    P04626 [Other Products]
 Molecular Weight    97,382 Da
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 NCBI Official Full Name    ERBB2, partial
 NCBI Official Synonym Full Names    erb-b2 receptor tyrosine kinase 2
 NCBI Official Symbol    ERBB2 [Similar Products]
 NCBI Official Synonym Symbols   
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-2
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-2
 UniProt Synonym Protein Names   
Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen: CD340
 Protein Family    Receptor tyrosine-protein kinase
 UniProt Gene Name    ERBB2 [Similar Products]
 UniProt Synonym Gene Names    HER2; MLN19; NEU; NGL; MLN 19 [Similar Products]
 UniProt Entry Name    ERBB2_HUMAN
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 UniProt Comments for ERBB2    HER2: a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033.

Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: basolateral plasma membrane; cytoplasm; endosome membrane; nucleus; plasma membrane; receptor complex

Molecular Function: ErbB-3 class receptor binding; growth factor binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein C-terminus binding; protein heterodimerization activity; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; enzyme linked receptor protein signaling pathway; MAPKKK cascade; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of microtubule-based process; regulation of phosphoinositide 3-kinase cascade; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing

Disease: Gastric Cancer; Glioma Susceptibility 1; Lung Cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ERBB2 antibodyPathways associated with anti-ERBB2 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >3468 publications with ERBB2 and EGFR
 ERBB3 antibody  >957 publications with ERBB2 and ERBB3
 SRC antibody  >469 publications with ERBB2 and SRC
 CTNNB1 antibody  >218 publications with ERBB2 and CTNNB1
 GRB2 antibody  >111 publications with ERBB2 and GRB2
 ERBB2IP antibody  >50 publications with ERBB2 and ERBB2IP
 SHC1 antibody  >37 publications with ERBB2 and SHC1
 PTPN11 antibody  >16 publications with ERBB2 and PTPN11
 UBC antibody  >7 publications with ERBB2 and UBC
 HSP90AA1 antibody  >3 publications with ERBB2 and HSP90AA1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-ERBB2 antibodyOrgans/Tissues associated with anti-ERBB2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >13859 publications with ERBB2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3885 publications with ERBB2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >3253 publications with ERBB2 and Neoplasm Metastasis
 Recurrence Antibodies  >1931 publications with ERBB2 and Recurrence
 Disease Progression Antibodies  >1841 publications with ERBB2 and Disease Progression
 Neoplasms, Experimental Antibodies  >1821 publications with ERBB2 and Neoplasms, Experimental
 Gastrointestinal Neoplasms Antibodies  >1509 publications with ERBB2 and Gastrointestinal Neoplasms
 Lymphatic Metastasis Antibodies  >1469 publications with ERBB2 and Lymphatic Metastasis
 Carcinogenesis Antibodies  >1414 publications with ERBB2 and Carcinogenesis
 Lung Neoplasms Antibodies  >1324 publications with ERBB2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2415 publications with ERBB2 and Blood
 Lymph Node Antibodies  >2166 publications with ERBB2 and Lymph Node
 Lung Antibodies  >1560 publications with ERBB2 and Lung
 Stomach Antibodies  >920 publications with ERBB2 and Stomach
 Brain Antibodies  >739 publications with ERBB2 and Brain
 Liver Antibodies  >659 publications with ERBB2 and Liver
 Prostate Antibodies  >531 publications with ERBB2 and Prostate
 Bone Antibodies  >525 publications with ERBB2 and Bone
 Mammary Gland Antibodies  >496 publications with ERBB2 and Mammary Gland
 Heart Antibodies  >476 publications with ERBB2 and Heart
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