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anti-ERBB2 antibody :: Rabbit ERBB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9212985
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERBB2, Polyclonal Antibody

 Also Known As   

ERBB2 Antibody (C-term Y1248)

 Product Synonym Names    Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340; ERBB2; HER2; MLN19; NEU; NGL
 Product Gene Name   

anti-ERBB2 antibody

[Similar Products]
 Antibody/Peptide Pairs    ERBB2 peptide (MBS9227083) is used for blocking the activity of ERBB2 antibody (MBS9212985)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    1227-1255
 OMIM    137215
 3D Structure    ModBase 3D Structure for P04626
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Mouse, Rat)
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 Specificity    This ERBB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1227-1255 amino acids from the C-terminal region of human ERBB2.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.32 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ERBB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ERBB2 antibody

   ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues.
 Product Categories/Family for anti-ERBB2 antibody    Cancer; Signal Transduction
 Applications Tested/Suitable for anti-ERBB2 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ERBB2 antibody    WB~~1:1000
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 Western Blot (WB) of anti-ERBB2 antibody    Western blot analysis of ERBB2(arrow) using rabbit polyclonal ERBB2 Antibody (Y1248). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ERBB2 gene (Lane 2) (Origene Technologies).
anti-ERBB2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ERBB2 antibody    Western blot analysis of ERBB2 (arrow) in T47D cell lysates, either noninduced (Lane 1) or induced with HRG (Lane 2).
anti-ERBB2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ERBB2 antibody    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with ErbB2-pY1248.ctrl antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-ERBB2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ERBB2. It may not necessarily be applicable to this product.
 NCBI GI #    54792098
 NCBI GeneID    2064
 NCBI Accession #    NP_001005862.1 [Other Products]
 NCBI Related Accession #    NP_004439.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005862.2 [Other Products]
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 UniProt Primary Accession #    P04626 [Other Products]
 UniProt Secondary Accession #    Q14256; Q6LDV1; Q9UMK4; B2RZG3; B4DHN3; X5D2V5 [Other Products]
 UniProt Related Accession #    P04626 [Other Products]
 Molecular Weight    137910
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 NCBI Official Full Name    receptor tyrosine-protein kinase erbB-2 isoform b
 NCBI Official Synonym Full Names    erb-b2 receptor tyrosine kinase 2
 NCBI Official Symbol    ERBB2 [Similar Products]
 NCBI Official Synonym Symbols   
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-2
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-2
 UniProt Synonym Protein Names   
Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen: CD340
 Protein Family    Receptor tyrosine-protein kinase
 UniProt Gene Name    ERBB2 [Similar Products]
 UniProt Synonym Gene Names    HER2; MLN19; NEU; NGL; MLN 19 [Similar Products]
 UniProt Entry Name    ERBB2_HUMAN
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 NCBI Summary for ERBB2    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ERBB2    HER2: a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033.

Protein type: EC 2.7.10.1; Oncoprotein; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Protein kinase, TK; TK group; EGFR family

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: perinuclear region of cytoplasm; basolateral plasma membrane; cytoplasm; apical plasma membrane; integral to membrane; plasma membrane; endosome membrane; cytoplasmic vesicle; nucleus; receptor complex

Molecular Function: protein dimerization activity; protein C-terminus binding; identical protein binding; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; protein binding; transmembrane receptor activity; ErbB-3 class receptor binding; protein heterodimerization activity; protein-tyrosine kinase activity; growth factor binding; ATP binding

Biological Process: myelination; axon guidance; phosphoinositide 3-kinase cascade; positive regulation of cell adhesion; peptidyl-tyrosine phosphorylation; wound healing; positive regulation of translation; nerve growth factor receptor signaling pathway; heart development; protein amino acid autophosphorylation; motor axon guidance; signal transduction; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of MAP kinase activity; cell surface receptor linked signal transduction; oligodendrocyte differentiation; neuromuscular junction development; epidermal growth factor receptor signaling pathway; negative regulation of immature T cell proliferation in the thymus; regulation of microtubule-based process; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; positive regulation of cell growth; regulation of angiogenesis; peripheral nervous system development; cell proliferation; positive regulation of transcription from RNA polymerase III promoter; innate immune response; positive regulation of protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of epithelial cell proliferation

Disease: Gastric Cancer; Lung Cancer; Glioma Susceptibility 1
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Product References and Citations for anti-ERBB2 antibody

   Ehsani, A., et al., Genomics 15(2):426-429 (1993).
Yamamoto, T., et al., Nature 319(6050):230-234 (1986).
Coussens, L., et al., Science 230(4730):1132-1139 (1985).
Semba, K., et al., Proc. Natl. Acad. Sci. U.S.A. 82(19):6497-6501 (1985).
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 Research Articles on ERBB2    1. Neurotensin and its receptor NTSR1 causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ERBB2 antibodyPathways associated with anti-ERBB2 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >3063 publications with ERBB2 and EGFR
 ERBB3 antibody  >850 publications with ERBB2 and ERBB3
 SRC antibody  >411 publications with ERBB2 and SRC
 CTNNB1 antibody  >189 publications with ERBB2 and CTNNB1
 GRB2 antibody  >109 publications with ERBB2 and GRB2
 ERBB2IP antibody  >44 publications with ERBB2 and ERBB2IP
 SHC1 antibody  >36 publications with ERBB2 and SHC1
 PTPN11 antibody  >13 publications with ERBB2 and PTPN11
 UBC antibody  >4 publications with ERBB2 and UBC
 HSP90AA1 antibody  >1 publications with ERBB2 and HSP90AA1
 Products by Pathway  Pathway Diagram
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Diseases associated with anti-ERBB2 antibodyOrgans/Tissues associated with anti-ERBB2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >12948 publications with ERBB2 and Breast Neoplasms
 Carcinoma Antibodies  >6921 publications with ERBB2 and Carcinoma
 Adenocarcinoma Antibodies  >3658 publications with ERBB2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >3035 publications with ERBB2 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >1746 publications with ERBB2 and Neoplasms, Experimental
 Disease Progression Antibodies  >1710 publications with ERBB2 and Disease Progression
 Gastrointestinal Neoplasms Antibodies  >1391 publications with ERBB2 and Gastrointestinal Neoplasms
 Lymphatic Metastasis Antibodies  >1382 publications with ERBB2 and Lymphatic Metastasis
 Carcinogenesis Antibodies  >1349 publications with ERBB2 and Carcinogenesis
 Lung Neoplasms Antibodies  >1244 publications with ERBB2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2270 publications with ERBB2 and Blood
 Lymph Node Antibodies  >2023 publications with ERBB2 and Lymph Node
 Lung Antibodies  >1462 publications with ERBB2 and Lung
 Stomach Antibodies  >831 publications with ERBB2 and Stomach
 Brain Antibodies  >685 publications with ERBB2 and Brain
 Liver Antibodies  >615 publications with ERBB2 and Liver
 Prostate Antibodies  >514 publications with ERBB2 and Prostate
 Bone Antibodies  >500 publications with ERBB2 and Bone
 Mammary Gland Antibodies  >474 publications with ERBB2 and Mammary Gland
 Heart Antibodies  >444 publications with ERBB2 and Heart
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