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anti-ERBB3 antibody :: Goat ERBB3/HER3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420204
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERBB3/HER3, Polyclonal Antibody

 Also Known As   

Goat anti-ERBB3/HER3 Antibody

 Product Synonym Names    ERBB3; HER3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); HGNC: 3431; ErbB-3; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; erbB-3; LCCS2; MGC88033; receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian; ERBB3 antibody; HER3 antibody; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody; HGNC: 3431 antibody; ErbB-3 antibody; MDA-BF-1 antibody; c-erbB-3 antibody; c-erbB3 antibody; erbB3-S antibody; p180-ErbB3 antibody; p45-sErbB3 antibody; p85-sErbB3 antibody; erbB-3 antibody; LCCS2 antibody; MGC88033 antibody; receptor tyrosine-protein kinase erbB-3 antibody; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody; ERBB3 / HER3
 Product Gene Name   

anti-ERBB3 antibody

[Similar Products]
 Product Synonym Gene Name    HER3 [Similar Products]
 Antibody/Peptide Pairs    ERBB3 / HER3 peptide (MBS426180) is used for blocking the activity of ERBB3/HER3 antibody (MBS420204)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    HSRLFPKANA QRT
 OMIM    190151
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-HSRLFPKANAQRT, from the C Terminus of the protein sequence according to NP_001973.2.
 Epitope    C Terminus
 Note    This antibody is expected to recognise isoform 1 (NP_001973.2) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ERBB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ERBB3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ERBB3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 150kDa band observed in human lysates of T cell line JURKAT (calculated MW of 148kDa according to NP_001973.2). Recommended concentration: 0.1-0.3ug/ml. A minor band of unknown identity was also consistently observed at 48kDa. This band was successfully blocked by incubation with the immunising peptide.
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 Western Blot (WB) of anti-ERBB3 antibody    (0.1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ERBB3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ERBB3. It may not necessarily be applicable to this product.
 NCBI GI #    54792100
 NCBI GeneID    2065
 NCBI Accession #    NP_001973.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001982.3 [Other Products]
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 UniProt Secondary Accession #    Q9BUD7; A8K6L6; B4DIK7; B4DV32; E9PDT8 [Other Products]
 UniProt Related Accession #    P21860 [Other Products]
 Molecular Weight    77,426 Da
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 NCBI Official Full Name    receptor tyrosine-protein kinase erbB-3 isoform 1
 NCBI Official Synonym Full Names    erb-b2 receptor tyrosine kinase 3
 NCBI Official Symbol    ERBB3 [Similar Products]
 NCBI Official Synonym Symbols   
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-3
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-3
 UniProt Synonym Protein Names   
Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
 Protein Family    Receptor tyrosine-protein kinase
 UniProt Gene Name    ERBB3 [Similar Products]
 UniProt Synonym Gene Names    HER3 [Similar Products]
 UniProt Entry Name    ERBB3_HUMAN
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 NCBI Summary for ERBB3    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ERBB3    HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.

Protein type: Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; TK group; EGFR family

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral to plasma membrane; intracellular; lateral plasma membrane; plasma membrane; receptor complex

Molecular Function: ATP binding; growth factor binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor activity

Biological Process: cranial nerve development; heart development; MAPKKK cascade; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive regulation of GTPase activity; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing

Disease: Lethal Congenital Contracture Syndrome 2
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 Research Articles on ERBB3    1. Findings provide clues regarding the role of the miR-143/145 cluster as a tumor suppressor in breast cancer through the inhibition of ERBB3 translation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ERBB3 antibodyPathways associated with anti-ERBB3 antibody
 Reference Product  PubMed Publications
 ERBB2 antibody  >957 publications with ERBB3 and ERBB2
 EGFR antibody  >557 publications with ERBB3 and EGFR
 NRG1 antibody  >134 publications with ERBB3 and NRG1
 PA2G4 antibody  >45 publications with ERBB3 and PA2G4
 AKT1 antibody  >31 publications with ERBB3 and AKT1
 RNF41 antibody  >25 publications with ERBB3 and RNF41
 GRB2 antibody  >23 publications with ERBB3 and GRB2
 NRG2 antibody  >21 publications with ERBB3 and NRG2
 SHC1 antibody  >8 publications with ERBB3 and SHC1
 PIK3R1 antibody  >2 publications with ERBB3 and PIK3R1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with anti-ERBB3 antibodyOrgans/Tissues associated with anti-ERBB3 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >271 publications with ERBB3 and Breast Neoplasms
 Carcinoma Antibodies  >265 publications with ERBB3 and Carcinoma
 Adenocarcinoma Antibodies  >114 publications with ERBB3 and Adenocarcinoma
 Lung Neoplasms Antibodies  >98 publications with ERBB3 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >76 publications with ERBB3 and Neoplasms, Experimental
 Disease Progression Antibodies  >74 publications with ERBB3 and Disease Progression
 Nervous System Diseases Antibodies  >72 publications with ERBB3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >61 publications with ERBB3 and Disease Models, Animal
 Prostatic Neoplasms Antibodies  >39 publications with ERBB3 and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >33 publications with ERBB3 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >143 publications with ERBB3 and Lung
 Nerve Antibodies  >141 publications with ERBB3 and Nerve
 Brain Antibodies  >92 publications with ERBB3 and Brain
 Muscle Antibodies  >82 publications with ERBB3 and Muscle
 Prostate Antibodies  >62 publications with ERBB3 and Prostate
 Vascular Antibodies  >54 publications with ERBB3 and Vascular
 Liver Antibodies  >49 publications with ERBB3 and Liver
 Embryonic Tissue Antibodies  >48 publications with ERBB3 and Embryonic Tissue
 Heart Antibodies  >47 publications with ERBB3 and Heart
 Stomach Antibodies  >40 publications with ERBB3 and Stomach
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