NP_006846.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 28 kD Predicted: 26 kDa
NCBI Official Full Name
ER lumen protein-retaining receptor 3 isoform a
NCBI Official Synonym Full Names
KDEL endoplasmic reticulum protein retention receptor 3
NCBI Official Synonym Symbols
NCBI Protein Information
ER lumen protein-retaining receptor 3
UniProt Protein Name
ER lumen protein-retaining receptor 3
UniProt Synonym Protein Names
KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3
UniProt Synonym Gene Names
NCBI Summary for ERD23
This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for ERD23
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L ().
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Pathways associated with anti-ERD23 antibody
Diseases associated with anti-ERD23 antibody
Organs/Tissues associated with anti-ERD23 antibody
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