KGL94058.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
NCBI Official Full Name
ERO1-like beta, partial
UniProt Protein Name
ERO1-like protein beta
UniProt Synonym Protein Names
Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta
UniProt Synonym Gene Names
UniProt Entry Name
ERO1B_HUMAN
UniProt Comments for ERO1LB
ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family.
Protein type: Endoplasmic reticulum; Oxidoreductase; EC 1.8.4.-
Chromosomal Location of Human Ortholog: 1q42.2-q43
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum
Molecular Function: protein binding; unfolded protein binding; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor
Biological Process: insulin processing; protein maturation via protein folding; extracellular matrix organization and biogenesis; 4-hydroxyproline metabolic process; protein folding; cell redox homeostasis; glucose homeostasis
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Products associated with anti-ERO1LB antibody
Diseases associated with anti-ERO1LB antibody
Organs/Tissues associated with anti-ERO1LB antibody
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