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anti-ERO1B antibody :: Rabbit anti-Human, mouse ERO1B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7003509
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERO1B, Polyclonal Antibody

★Popular Item★
 Also Known As   

ERO1B Antibody

 Product Synonym Names    ERO1-like protein beta; ERO1-L-beta; Endoplasmic reticulum oxidoreductase beta; ERO1B
 Product Gene Name   

anti-ERO1B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615437
 3D Structure    ModBase 3D Structure for Q86YB8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human ERO1-like protein beta protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ERO1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ERO1B antibody

   Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
 Applications Tested/Suitable for anti-ERO1B antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-ERO1B antibody    Western blot
All lanes: ERO1B antibody at 3.2ug/ml
Lane 1: MCF7 whole cell lysate
Lane 2: U251 whole cell lysate
Lane 3: Mouse liver tissue
Lane 4: U87 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 54,17 kDa
Observed band size: 54 kDa

anti-ERO1B antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ERO1B antibody    Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7003509 at dilution of 1:100
anti-ERO1B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ERO1B antibody    Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7003509 at dilution of 1:100
anti-ERO1B antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ERO1B. It may not necessarily be applicable to this product.
 NCBI GI #    239582761
 NCBI GeneID    56605
 NCBI Accession #    NP_063944.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_019891.3 [Other Products]
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 UniProt Primary Accession #    Q86YB8 [Other Products]
 UniProt Secondary Accession #    Q5T1H4; Q8IZ11; Q9NR62; B4DF57 [Other Products]
 UniProt Related Accession #    Q86YB8 [Other Products]
 Molecular Weight    16,096 Da
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 NCBI Official Full Name    ERO1-like protein beta
 NCBI Official Synonym Full Names    endoplasmic reticulum oxidoreductase beta
 NCBI Official Symbol    ERO1B [Similar Products]
 NCBI Official Synonym Symbols   
ERO1LB; Ero1beta
[Similar Products]
 NCBI Protein Information    ERO1-like protein beta
 UniProt Protein Name    ERO1-like protein beta
 UniProt Synonym Protein Names   
Endoplasmic reticulum oxidoreductase beta
 Protein Family    ERO1-like protein
 UniProt Gene Name    ERO1B [Similar Products]
 UniProt Synonym Gene Names    ERO1-L-beta [Similar Products]
 UniProt Entry Name    ERO1B_HUMAN
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 UniProt Comments for ERO1B    ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family.

Protein type: Oxidoreductase; Endoplasmic reticulum; EC 1.8.4.-

Chromosomal Location of Human Ortholog: 1q42.2-q43

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function: oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; protein binding; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; unfolded protein binding

Biological Process: 4-hydroxyproline metabolic process; cell redox homeostasis; extracellular matrix organization and biogenesis; glucose homeostasis; insulin processing; protein folding; protein maturation via protein folding
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 Research Articles on ERO1B    1. In the present work, it was shown that recombinant human Ero1beta is twice as active as Ero1alpha in enzymatic assays.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ERO1B antibody
 Products by Pathway  Pathway Diagram
 Insulin Processing Pathway antibodies  Insulin Processing Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
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