NP_063944.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,096 Da
NCBI Official Full Name
ERO1-like protein beta
NCBI Official Synonym Full Names
endoplasmic reticulum oxidoreductase beta
NCBI Protein Information
ERO1-like protein beta
UniProt Protein Name
ERO1-like protein beta
UniProt Synonym Protein Names
Endoplasmic reticulum oxidoreductase beta
UniProt Synonym Gene Names
UniProt Entry Name
ERO1B_HUMAN
UniProt Comments for ERO1B
ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family.
Protein type: Oxidoreductase; Endoplasmic reticulum; EC 1.8.4.-
Chromosomal Location of Human Ortholog: 1q42.2-q43
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; protein binding; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; unfolded protein binding
Biological Process: 4-hydroxyproline metabolic process; cell redox homeostasis; extracellular matrix organization and biogenesis; glucose homeostasis; insulin processing; protein folding; protein maturation via protein folding
Research Articles on ERO1B
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Pathways associated with anti-ERO1B antibody
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