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anti-ERV3 antibody :: Goat ERV3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422488 anti-ERV3 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERV3, Polyclonal Antibody

 Also Known As   

Goat anti-ERV3 Antibody

 Product Synonym Names    ERV3; endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9); ERV-R; H-PLK; HERV-R; ERV-3 envelope protein; endogenous retroviral sequence 3; envelope polyprotein; endogenous retroviral sequence 3 antibody; endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9) antibody; envelope polyprotein antibody; ERV-3 envelope protein antibody; ERV-R antibody; HERV-R antibody; H-PLK antibody; ERV3 antibody
 Product Gene Name   

anti-ERV3 antibody

[Similar Products]
 Antibody/Peptide Pairs    ERV3 peptide (MBS427485) is used for blocking the activity of ERV3 antibody (MBS422488)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PQDNFTLTAS S
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PQDNFTLTASS, from the internal region of the protein sequence according to NP_001007254.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ERV3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ERV3 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-ERV3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx 30kDa band in Human Placenta lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 67.9kDa according to NP_001007254.2. The 30kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for ERV3. It may not necessarily be applicable to this product.
 NCBI GI #    145651814
 NCBI GeneID    2086
 NCBI Accession #    NP_001007254.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001007253.3 [Other Products]
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 UniProt Related Accession #    Q14264 [Other Products]
 Molecular Weight    67,942 Da
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 NCBI Official Full Name    endogenous retrovirus group 3 member 1 Env polyprotein
 NCBI Official Synonym Full Names    endogenous retrovirus group 3 member 1
 NCBI Official Symbol    ERV3-1 [Similar Products]
 NCBI Official Synonym Symbols   
ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
[Similar Products]
 NCBI Protein Information    endogenous retrovirus group 3 member 1 Env polyprotein
 UniProt Protein Name    Endogenous retrovirus group 3 member 1 Env polyprotein
 UniProt Synonym Protein Names   
ERV-3 envelope protein; ERV3 envelope protein
 UniProt Gene Name    ERV3-1 [Similar Products]
 UniProt Synonym Gene Names    ERV3; ERV3 envelope protein; ERV-R envelope protein; SU; TM [Similar Products]
 UniProt Entry Name    ENR1_HUMAN
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 NCBI Summary for ERV3    The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ERV3    ERV3: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I R env subfamily.

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: viral envelope
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 Research Articles on ERV3    1. Letter: report elevated ERV3-1 levels in colorectal neoplasms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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