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anti-ERVK-7 antibody :: Rabbit anti-Human ERVK-7 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9216561
Unit / Price
0.05 mL  /  $155 +1 FREE 8GB USB
0.2 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERVK-7, Polyclonal Antibody

 Also Known As   

ERVK-7 Antibody (N-Term)

 Product Synonym Names    Purified Rabbit Polyclonal Antibody (Pab); Endogenous retrovirus group K member 7 Env polyprotein; Envelope polyprotein; HERV-K(III) envelope protein; HERV-K102 envelope protein; HERV-K_1q22 provirus ancestral Env polyprotein; Surface protein; SU; Transmembrane protein; TM, ERVK-7
 Product Gene Name   

anti-ERVK-7 antibody

[Similar Products]
 Antibody/Peptide Pairs    ERVK-7 peptide (MBS9230428) is used for blocking the activity of ERVK-7 antibody (MBS9216561)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614013
 3D Structure    ModBase 3D Structure for P61567
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 Clonality    Polyclonal
 Isotype    Ig
 Clone Number    RB53926
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This ERVK-7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 96-128 amino acids from human ERVK-7.
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Cellular Location    Virion
 Tissue Location    Expressed in lung, placenta, testis, and peripheral blood lymphocytes
 Clone Names    RB53926
    
 Function    Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
  Cellular Location    Virion.
  Tissue Location    Expressed in lung, placenta, testis and peripheral blood lymphocytes.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ERVK-7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ERVK-7 antibody

   Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
 Product Categories/Family for anti-ERVK-7 antibody    Crown Antibodies; Cell Biology; Microbiology
 Applications Tested/Suitable for anti-ERVK-7 antibody   

Western Blot (WB), ELISA, IHC-P

 Application Notes for anti-ERVK-7 antibody    WB~~:1000-1:2000
IHC-P~~1:25
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 Test Data of anti-ERVK-7 antibody    MBS9216561 staining ERVK-7 in human placenta tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
anti-ERVK-7 antibody Test Data image
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 Test Data of anti-ERVK-7 antibody    MBS9216561 staining ERVK-7 in human placenta tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixedwith formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
anti-ERVK-7 antibody Test Data image
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 Western Blot (WB) of anti-ERVK-7 antibody    All lanes : Anti-ERVK-7 Antibody (N-Term) at 1:1000-1:2000 dilution
Lane 1: Raji whole cell lysate
Lane 2: human lung lysate
Lane 3: human testis lysate

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 67 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-ERVK-7 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ERVK-7. It may not necessarily be applicable to this product.
 NCBI GI #    47605618
 NCBI Accession #    P61567.1 [Other Products]
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 UniProt Primary Accession #    P61567 [Other Products]
 Molecular Weight    66649
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 NCBI Official Full Name    Endogenous retrovirus group K member 7 Env polyprotein
 UniProt Protein Name    Endogenous retrovirus group K member 7 Env polyprotein
 UniProt Synonym Protein Names   
Envelope polyprotein; HERV-K(III) envelope protein; HERV-K102 envelope protein; HERV-K_1q22 provirus ancestral Env polyprotein
 Protein Family    Endogenous retrovirus group K member 7 Np9 protein
 UniProt Gene Name    ERVK-7 [Similar Products]
 UniProt Synonym Gene Names    SU; TM [Similar Products]
 UniProt Entry Name    ENK7_HUMAN
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 NCBI Summary for ERVK-7    HERV-K102: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22
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 UniProt Comments for ERVK-7    HERV-K102: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22
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Product References and Citations for anti-ERVK-7 antibody

   Barbulescu M.,et al.Curr. Biol. 9:861-868(1999). Sugimoto J.,et al.Genomics 72:137-144(2001). Wang-Johanning F.,et al.Oncogene 22:1528-1535(2003).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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