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anti-ERVW-1 antibody :: Rabbit anti-Human ERVW-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051530
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERVW-1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ERVW-1 Antibody

 Product Synonym Names    Syncytin-1; Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; Syncytin; Surface protein; SU; gp50; Transmembrane protein; TM; gp24; ERVW-1; ERVWE1
 Product Gene Name   

anti-ERVW-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF072503 mRNA
 3D Structure    ModBase 3D Structure for Q9UQF0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Syncytin-1 protein (21-443AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-130888 / sc-30640 / sc-50369
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ERVW-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ERVW-1 antibody

   This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed: 10708449, PubMed: 12050356, PubMed: 23492904).
 Applications Tested/Suitable for anti-ERVW-1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ERVW-1 antibody    IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Immunohistochemistry (IHC) of anti-ERVW-1 antibody    Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7051530 at dilution of 1:100
anti-ERVW-1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ERVW-1 antibody    Immunofluorescent analysis of HepG2 cells using MBS7051530 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ERVW-1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ERVW-1. It may not necessarily be applicable to this product.
 NCBI GI #    195963433
 NCBI GeneID    30816
 NCBI Accession #    NP_001124397.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130925.1 [Other Products]
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 UniProt Primary Accession #    Q9UQF0 [Other Products]
 UniProt Secondary Accession #    O95244; O95245; Q8NHY7; Q9NRZ2; Q9NZG3; B2RPD4 [Other Products]
 UniProt Related Accession #    Q9UQF0 [Other Products]
 Molecular Weight    59,866 Da
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 NCBI Official Full Name    syncytin-1
 NCBI Official Synonym Full Names    endogenous retrovirus group W member 1
 NCBI Official Symbol    ERVW-1 [Similar Products]
 NCBI Official Synonym Symbols   
ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV
[Similar Products]
 NCBI Protein Information    syncytin-1
 UniProt Protein Name    Syncytin-1
 UniProt Synonym Protein Names   
Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; Syncytin
 Protein Family    Syncytin
 UniProt Gene Name    ERVW-1 [Similar Products]
 UniProt Synonym Gene Names    ERVWE1; SU; TM [Similar Products]
 UniProt Entry Name    SYCY1_HUMAN
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 NCBI Summary for ERVW-1    Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
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 UniProt Comments for ERVW-1    ERVWE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q21.2

Biological Process: anatomical structure morphogenesis; syncytium formation
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 Research Articles on ERVW-1    1. ERVWE1, ERVFRDE1 and ERV3 transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ERVW-1 antibodyDiseases associated with anti-ERVW-1 antibody
 Reference Product  PubMed Publications
 GCM1 antibody  >1 publications with ERVW-1 and GCM1
 Disease Name  Pubmed Publications
 Pregnancy Complications Antibodies  >2 publications with ERVW-1 and Pregnancy Complications
 Embryo Loss Antibodies  >1 publications with ERVW-1 and Embryo Loss
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