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anti-ETV1 antibody :: Rabbit ETV1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820464
Immunohistochemistry (IHC)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ETV1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-ETV1 Antibody

 Product Synonym Names    ER81; ETS translocation variant 1; Ets-related protein 81
 Product Gene Name   

anti-ETV1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ETV1 peptide (MBS823079) is used for blocking the activity of ETV1 antibody (MBS820464)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612219
 3D Structure    ModBase 3D Structure for P50549
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine
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 Specificity    Recognizes endogenous levels of ETV1 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ETV1. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-ETV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ETV1 antibody

   Rabbit polyclonal antibody to ETV1
 Applications Tested/Suitable for anti-ETV1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

 Application Notes for anti-ETV1 antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200), IP (1/10 - 1/100)
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 Western Blot (WB) of anti-ETV1 antibody    anti-ETV1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ETV1 antibody    Immunohistochemical analysis of ETV1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-ETV1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ETV1. It may not necessarily be applicable to this product.
 NCBI GI #    253683427
 NCBI GeneID    2115
 NCBI Accession #    NP_001156619.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163147.1 [Other Products]
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 UniProt Primary Accession #    P50549 [Other Products]
 UniProt Secondary Accession #    O75849; Q4KMQ6; Q59GA7; A4D118; B2R768; B7Z2I4; B7Z618; B7Z9P2; C9JT37; E9PHB1; F5GXR2 [Other Products]
 UniProt Related Accession #    P50549 [Other Products]
 Molecular Weight    50,217 Da
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 NCBI Official Full Name    ETS translocation variant 1 isoform b
 NCBI Official Synonym Full Names    ets variant 1
 NCBI Official Symbol    ETV1 [Similar Products]
 NCBI Official Synonym Symbols   
ER81
[Similar Products]
 NCBI Protein Information    ETS translocation variant 1; ets variant gene 1; ets-related protein 81
 UniProt Protein Name    ETS translocation variant 1
 UniProt Synonym Protein Names   
Ets-related protein 81
 Protein Family    ETS translocation
 UniProt Gene Name    ETV1 [Similar Products]
 UniProt Synonym Gene Names    ER81 [Similar Products]
 UniProt Entry Name    ETV1_HUMAN
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 NCBI Summary for ETV1    This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
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 UniProt Comments for ETV1    ETV1: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Defects in ETV1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. Belongs to the ETS family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; peripheral nervous system neuron development; axon guidance; muscle development; mechanosensory behavior; positive regulation of transcription from RNA polymerase II promoter; cell differentiation
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 Research Articles on ETV1    1. ETV1 expression is significantly correlated with Snail expression in human gastric tumor samples. In summary, we present data that ETV1 promotes Snail expression to induce EMT-like metastatic progression in gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ETV1 antibodyPathways associated with anti-ETV1 antibody
 Reference Product  PubMed Publications
 ERG antibody  >94 publications with ETV1 and ERG
 TMPRSS2 antibody  >50 publications with ETV1 and TMPRSS2
 EWSR1 antibody  >18 publications with ETV1 and EWSR1
 RFWD2 antibody  >3 publications with ETV1 and RFWD2
 RPS6KA1 antibody  >2 publications with ETV1 and RPS6KA1
 MAPKAPK2 antibody  >2 publications with ETV1 and MAPKAPK2
 POMC antibody  >1 publications with ETV1 and POMC
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 P38 Signaling Mediated By MAPKAP Kinases Pathway antibodies  P38 Signaling Mediated By MAPKAP Kinases Pathway Diagram
Diseases associated with anti-ETV1 antibodyOrgans/Tissues associated with anti-ETV1 antibody
 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >70 publications with ETV1 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >70 publications with ETV1 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >19 publications with ETV1 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >17 publications with ETV1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >13 publications with ETV1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >10 publications with ETV1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >10 publications with ETV1 and Neoplasm Metastasis
 Hyperplasia Antibodies  >8 publications with ETV1 and Hyperplasia
 Neoplasms, Experimental Antibodies  >5 publications with ETV1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >5 publications with ETV1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >88 publications with ETV1 and Prostate
 Brain Antibodies  >37 publications with ETV1 and Brain
 Bone Antibodies  >21 publications with ETV1 and Bone
 Embryonic Tissue Antibodies  >11 publications with ETV1 and Embryonic Tissue
 Muscle Antibodies  >11 publications with ETV1 and Muscle
 Ganglia Antibodies  >8 publications with ETV1 and Ganglia
 Lung Antibodies  >5 publications with ETV1 and Lung
 Vascular Antibodies  >4 publications with ETV1 and Vascular
 Eye Antibodies  >4 publications with ETV1 and Eye
 Mammary Gland Antibodies  >4 publications with ETV1 and Mammary Gland
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